MOUSE:UT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Slc14a1
Protein Name(s)	Urea transporter 1 Solute carrier family 14 member 1 Urea transporter B UT-B Urea transporter, erythrocyte
External Links
UniProt	Q8VHL0
EMBL	AF448798 AJ420967 AK012066 AK041979 AK153891 CH466528 CH466528 BC058594 BC086673 BC100570
CCDS	CCDS29360.1 CCDS50330.1
RefSeq	NP_001164481.1 NP_001164482.1 NP_082398.1
UniGene	Mm.33832
ProteinModelPortal	Q8VHL0
SMR	Q8VHL0
STRING	10090.ENSMUSP00000025433
BindingDB	Q8VHL0
ChEMBL	CHEMBL2163171
MaxQB	Q8VHL0
PaxDb	Q8VHL0
PRIDE	Q8VHL0
Ensembl	ENSMUST00000091813 ENSMUST00000160292 ENSMUST00000160639
GeneID	108052
KEGG	mmu:108052
UCSC	uc008fsc.2 uc008fsd.2
CTD	6563
MGI	MGI:1351654
eggNOG	COG4413
GeneTree	ENSGT00390000018729
HOGENOM	HOG000065705
HOVERGEN	HBG000540
InParanoid	Q8VHL0
KO	K08716
OMA	VGVGQIY
OrthoDB	EOG7GBFX8
TreeFam	TF332858
Reactome	REACT_217615
NextBio	359947
PRO	PR:Q8VHL0
Proteomes	UP000000589
Bgee	Q8VHL0
Genevestigator	Q8VHL0
GO	GO:0016323 GO:0016021 GO:0005887 GO:0005886 GO:0015265 GO:0015204 GO:0005372 GO:0071918 GO:0015840 GO:0006833
Gene3D	1.10.3430.10
InterPro	IPR029020 IPR004937
PANTHER	PTHR10464
Pfam	PF03253
PIRSF	PIRSF016502

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071918	urea transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5QF96	P		Seeded From UniProt	complete
enables	GO:0015265	urea channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5QF96	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5QF96	C		Seeded From UniProt	complete
involved_in	GO:0071918	urea transmembrane transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351653 MGI:MGI:1351654 PANTHER:PTN002573341 RGD:3688 RGD:3689 UniProtKB:Q13336 UniProtKB:Q5QF96	P		Seeded From UniProt	complete
involved_in	GO:0015840	urea transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351653 MGI:MGI:1351654 PANTHER:PTN002573341 RGD:3688 RGD:3689 UniProtKB:Q13336 UniProtKB:Q5QF96 ZFIN:ZDB-GENE-030131-4833	P		Seeded From UniProt	complete
enables	GO:0015265	urea channel activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001627166 UniProtKB:Q13336 UniProtKB:Q5QF96	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001627166 UniProtKB:Q13336 UniProtKB:Q5QF96	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071918	urea transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13336	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13336	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015840	urea transport	PMID:11792714^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182112	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015840	urea transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3688	P		Seeded From UniProt	complete
enables	GO:0015265	urea channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13336	F		Seeded From UniProt	complete
enables	GO:0015204	urea transmembrane transporter activity	PMID:11792714^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182112	F		Seeded From UniProt	complete
enables	GO:0015204	urea transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3688	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:12133842^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103201	P	occurs_in:(CL:0000232)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:11792714^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13336	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12133842^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000232)	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13336	C		Seeded From UniProt	complete
enables	GO:0005372	water transmembrane transporter activity	PMID:11792714^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071918	urea transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13336 ensembl:ENSP00000390637	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13336 ensembl:ENSP00000390637	C		Seeded From UniProt	complete
enables	GO:0015265	urea channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13336 ensembl:ENSP00000390637	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13336 ensembl:ENSP00000390637	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13336 ensembl:ENSP00000390637	C		Seeded From UniProt	complete
enables	GO:0015204	urea transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004937	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004937	C		Seeded From UniProt	complete
involved_in	GO:0071918	urea transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004937	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:11792714^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Yang, B et al. (2002) Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J. Biol. Chem. 277 10633-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Yang, B & Verkman, AS (2002) Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J. Biol. Chem. 277 36782-6 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11792714-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Yang, B et al. (2002) Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J. Biol. Chem. 277 10633-7 PubMed GONUTS page

[PMID:12133842-3] 3.0 ^3.1 Yang, B & Verkman, AS (2002) Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J. Biol. Chem. 277 36782-6 PubMed GONUTS page

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MOUSE:UT1

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