MOUSE:TYSY

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tyms
Protein Name(s)	Thymidylate synthase TS TSase
External Links
UniProt	P07607
EMBL	M13019 M13352 J02617 M13347 M13348 M13349 M13350 M13351 X14489
CCDS	CCDS19154.1
PIR	A26323
RefSeq	NP_067263.1
UniGene	Mm.268395
PDB	3IHI 4E5O 4EB4 4EIN 4EZ8
PDBsum	3IHI 4E5O 4EB4 4EIN 4EZ8
ProteinModelPortal	P07607
SMR	P07607
STRING	10090.ENSMUSP00000026846
BindingDB	P07607
ChEMBL	CHEMBL3160
GuidetoPHARMACOLOGY	2642
PhosphoSite	P07607
REPRODUCTION-2DPAGE	P07607
EPD	P07607
PaxDb	P07607
PRIDE	P07607
Ensembl	ENSMUST00000026846
GeneID	22171
KEGG	mmu:22171
UCSC	uc008wux.2
CTD	7298
MGI	MGI:98878
eggNOG	KOG0673 COG0207
HOGENOM	HOG000257899
HOVERGEN	HBG001934
InParanoid	P07607
KO	K00560
OMA	IVYELLW
PhylomeDB	P07607
TreeFam	TF353027
Reactome	R-MMU-113510 R-MMU-500753 R-MMU-69205
UniPathway	UPA00575
EvolutionaryTrace	P07607
NextBio	302116
PRO	PR:P07607
Proteomes	UP000000589
Bgee	P07607
CleanEx	MM_TYMS
ExpressionAtlas	P07607
Genevisible	P07607
GO	GO:0005737 GO:0005743 GO:0005759 GO:0005739 GO:0005730 GO:0005634 GO:0048037 GO:0008144 GO:0005542 GO:0003729 GO:0000166 GO:0004799 GO:0007568 GO:0051216 GO:0007623 GO:0048589 GO:0006231 GO:0006235 GO:0046078 GO:0019088 GO:0060574 GO:0031100 GO:0034097 GO:0042493 GO:0045471 GO:0051593 GO:0051384 GO:0046683 GO:0032570 GO:0009636 GO:0033189 GO:0035999 GO:0019860
Gene3D	3.30.572.10
HAMAP	MF_00008
InterPro	IPR023451 IPR000398 IPR020940
Pfam	PF00303
PRINTS	PR00108
SUPFAM	SSF55831
TIGRFAMs	TIGR03284
PROSITE	PS00091

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
involved_in	GO:0006231	dTMP biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11002 PANTHER:PTN000167391 PomBase:SPAC15E1.04 RGD:3921 SGD:S000005600 UniProtKB:P04818 UniProtKB:P9WFR9 WB:WBGene00022455 ZFIN:ZDB-GENE-040426-59	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11002 PANTHER:PTN000167391 TAIR:locus:2042649	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002610699 RGD:3921 TAIR:locus:2139544 UniProtKB:P04818	C	Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11002 PANTHER:PTN000167391 PomBase:SPAC15E1.04 RGD:3921 SGD:S000005600 UniProtKB:P04818 UniProtKB:P9WFR9 WB:WBGene00022455 ZFIN:ZDB-GENE-040426-59	F	Seeded From UniProt	complete
enables	GO:1990825	sequence-specific mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	F	Seeded From UniProt	complete
enables	GO:0048037	cofactor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046078	dUMP metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035999	tetrahydrofolate interconversion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017148	negative regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006417	regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006231	dTMP biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006231	dTMP biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	P	Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	C	Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	F	Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	F	Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	F	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	F	Seeded From UniProt	complete
enables	GO:0000900	translation repressor activity, mRNA regulatory element binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04818	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3921	F	Seeded From UniProt	complete
enables	GO:1990825	sequence-specific mRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	F	Seeded From UniProt	complete
involved_in	GO:0046683	response to organophosphorus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	P	Seeded From UniProt	complete
involved_in	GO:0035999	tetrahydrofolate interconversion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	P	Seeded From UniProt	complete
involved_in	GO:0006231	dTMP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	P	Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	C	Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	F	Seeded From UniProt	complete
enables	GO:0000900	translation repressor activity, mRNA regulatory element binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04818 ensembl:ENSP00000315644	F	Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0060574	intestinal epithelial cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0051593	response to folic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
enables	GO:0048037	cofactor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	F	Seeded From UniProt	complete
involved_in	GO:0046653	tetrahydrofolate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0046078	dUMP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0019860	uracil metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0019088	immortalization of host cell by virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	F	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0006231	dTMP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
involved_in	GO:0006206	pyrimidine nucleobase metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	C	Seeded From UniProt	complete
enables	GO:0005542	folic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	F	Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	F	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P45352 ensembl:ENSRNOP00000053086	F	Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000398 InterPro:IPR020940	F	Seeded From UniProt	complete
involved_in	GO:0006231	dTMP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000398 InterPro:IPR020940	P	Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.45	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C	Seeded From UniProt	complete
involved_in	GO:0009165	nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0545	P	Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C	Seeded From UniProt	complete
involved_in	GO:0006235	dTTP biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00575	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

MOUSE:TYSY

Contents

Annotations

Notes

References

a

c

d

e

f

g

i

l

m

n

o

p

r

s

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools