GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:TYSY
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Tyms | |
Protein Name(s) | Thymidylate synthase
TS TSase | |
External Links | ||
UniProt | P07607 | |
EMBL | M13019 M13352 J02617 M13347 M13348 M13349 M13350 M13351 X14489 | |
CCDS | CCDS19154.1 | |
PIR | A26323 | |
RefSeq | NP_067263.1 | |
UniGene | Mm.268395 | |
PDB | 3IHI 4E5O 4EB4 4EIN 4EZ8 | |
PDBsum | 3IHI 4E5O 4EB4 4EIN 4EZ8 | |
ProteinModelPortal | P07607 | |
SMR | P07607 | |
STRING | 10090.ENSMUSP00000026846 | |
BindingDB | P07607 | |
ChEMBL | CHEMBL3160 | |
GuidetoPHARMACOLOGY | 2642 | |
PhosphoSite | P07607 | |
REPRODUCTION-2DPAGE | P07607 | |
EPD | P07607 | |
PaxDb | P07607 | |
PRIDE | P07607 | |
Ensembl | ENSMUST00000026846 | |
GeneID | 22171 | |
KEGG | mmu:22171 | |
UCSC | uc008wux.2 | |
CTD | 7298 | |
MGI | MGI:98878 | |
eggNOG | KOG0673 COG0207 | |
HOGENOM | HOG000257899 | |
HOVERGEN | HBG001934 | |
InParanoid | P07607 | |
KO | K00560 | |
OMA | IVYELLW | |
PhylomeDB | P07607 | |
TreeFam | TF353027 | |
Reactome | R-MMU-113510 R-MMU-500753 R-MMU-69205 | |
UniPathway | UPA00575 | |
EvolutionaryTrace | P07607 | |
NextBio | 302116 | |
PRO | PR:P07607 | |
Proteomes | UP000000589 | |
Bgee | P07607 | |
CleanEx | MM_TYMS | |
ExpressionAtlas | P07607 | |
Genevisible | P07607 | |
GO | GO:0005737 GO:0005743 GO:0005759 GO:0005739 GO:0005730 GO:0005634 GO:0048037 GO:0008144 GO:0005542 GO:0003729 GO:0000166 GO:0004799 GO:0007568 GO:0051216 GO:0007623 GO:0048589 GO:0006231 GO:0006235 GO:0046078 GO:0019088 GO:0060574 GO:0031100 GO:0034097 GO:0042493 GO:0045471 GO:0051593 GO:0051384 GO:0046683 GO:0032570 GO:0009636 GO:0033189 GO:0035999 GO:0019860 | |
Gene3D | 3.30.572.10 | |
HAMAP | MF_00008 | |
InterPro | IPR023451 IPR000398 IPR020940 | |
Pfam | PF00303 | |
PRINTS | PR00108 | |
SUPFAM | SSF55831 | |
TIGRFAMs | TIGR03284 | |
PROSITE | PS00091 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11002 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11002 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002610699 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11002 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:1990825 |
sequence-specific mRNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0048037 |
cofactor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0046078 |
dUMP metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0035999 |
tetrahydrofolate interconversion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0017148 |
negative regulation of translation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008144 |
drug binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006417 |
regulation of translation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005730 |
nucleolus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005542 |
folic acid binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003729 |
mRNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000900 |
translation repressor activity, mRNA regulatory element binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3921 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:1990825 |
sequence-specific mRNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046683 |
response to organophosphorus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035999 |
tetrahydrofolate interconversion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0017148 |
negative regulation of translation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000900 |
translation repressor activity, mRNA regulatory element binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04818 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097421 |
liver regeneration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060574 |
intestinal epithelial cell maturation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051593 |
response to folic acid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051384 |
response to glucocorticoid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051216 |
cartilage development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048589 |
developmental growth |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0048037 |
cofactor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046653 |
tetrahydrofolate metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046078 |
dUMP metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045471 |
response to ethanol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034097 |
response to cytokine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033189 |
response to vitamin A |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032570 |
response to progesterone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019860 |
uracil metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019088 |
immortalization of host cell by virus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009636 |
response to toxic substance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008144 |
drug binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006206 |
pyrimidine nucleobase metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005730 |
nucleolus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005542 |
folic acid binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003729 |
mRNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P45352 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009165 |
nucleotide biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006235 |
dTTP biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00575 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
c
d
g
i
m
- Mammalia
- GO:0016020 ! membrane
- Metazoa
- GO:0032259 ! methylation
- GO:0008168 ! methyltransferase activity
- GO:0005759 ! mitochondrial matrix
- GO:0005743 ! mitochondrial inner membrane
- GO:0005739 ! mitochondrion
- GO:0003729 ! mRNA binding
- GO:0000900 ! mRNA regulatory element binding translation repressor activity
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
n
o
p
r
- GO:0006417 ! regulation of translation
- GO:0032570 ! response to progesterone
- GO:0033189 ! response to vitamin A
- GO:0046683 ! response to organophosphorus
- GO:0051593 ! response to folic acid
- GO:0051384 ! response to glucocorticoid
- GO:0045471 ! response to ethanol
- GO:0042493 ! response to drug
- GO:0034097 ! response to cytokine
- GO:0009636 ! response to toxic substance
- Rodentia
t