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MOUSE:TYSY

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tyms
Protein Name(s) Thymidylate synthase

TS TSase

External Links
UniProt P07607
EMBL M13019
M13352
J02617
M13347
M13348
M13349
M13350
M13351
X14489
CCDS CCDS19154.1
PIR A26323
RefSeq NP_067263.1
UniGene Mm.268395
PDB 3IHI
4E5O
4EB4
4EIN
4EZ8
PDBsum 3IHI
4E5O
4EB4
4EIN
4EZ8
ProteinModelPortal P07607
SMR P07607
STRING 10090.ENSMUSP00000026846
BindingDB P07607
ChEMBL CHEMBL3160
GuidetoPHARMACOLOGY 2642
PhosphoSite P07607
REPRODUCTION-2DPAGE P07607
EPD P07607
PaxDb P07607
PRIDE P07607
Ensembl ENSMUST00000026846
GeneID 22171
KEGG mmu:22171
UCSC uc008wux.2
CTD 7298
MGI MGI:98878
eggNOG KOG0673
COG0207
HOGENOM HOG000257899
HOVERGEN HBG001934
InParanoid P07607
KO K00560
OMA IVYELLW
PhylomeDB P07607
TreeFam TF353027
Reactome R-MMU-113510
R-MMU-500753
R-MMU-69205
UniPathway UPA00575
EvolutionaryTrace P07607
NextBio 302116
PRO PR:P07607
Proteomes UP000000589
Bgee P07607
CleanEx MM_TYMS
ExpressionAtlas P07607
Genevisible P07607
GO GO:0005737
GO:0005743
GO:0005759
GO:0005739
GO:0005730
GO:0005634
GO:0048037
GO:0008144
GO:0005542
GO:0003729
GO:0000166
GO:0004799
GO:0007568
GO:0051216
GO:0007623
GO:0048589
GO:0006231
GO:0006235
GO:0046078
GO:0019088
GO:0060574
GO:0031100
GO:0034097
GO:0042493
GO:0045471
GO:0051593
GO:0051384
GO:0046683
GO:0032570
GO:0009636
GO:0033189
GO:0035999
GO:0019860
Gene3D 3.30.572.10
HAMAP MF_00008
InterPro IPR023451
IPR000398
IPR020940
Pfam PF00303
PRINTS PR00108
SUPFAM SSF55831
TIGRFAMs TIGR03284
PROSITE PS00091

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11002
PANTHER:PTN000167391
PomBase:SPAC15E1.04
RGD:3921
SGD:S000005600
UniProtKB:P04818
UniProtKB:P9WFR9
WB:WBGene00022455
ZFIN:ZDB-GENE-040426-59

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11002
PANTHER:PTN000167391
TAIR:locus:2042649

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002610699
RGD:3921
TAIR:locus:2139544
UniProtKB:P04818

C

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11002
PANTHER:PTN000167391
PomBase:SPAC15E1.04
RGD:3921
SGD:S000005600
UniProtKB:P04818
UniProtKB:P9WFR9
WB:WBGene00022455
ZFIN:ZDB-GENE-040426-59

F

Seeded From UniProt

complete

enables

GO:1990825

sequence-specific mRNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

F

Seeded From UniProt

complete

enables

GO:0048037

cofactor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046078

dUMP metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035999

tetrahydrofolate interconversion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0017148

negative regulation of translation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006417

regulation of translation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006231

dTMP biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006231

dTMP biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

C

Seeded From UniProt

complete

enables

GO:0005542

folic acid binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

F

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

F

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

F

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

F

Seeded From UniProt

complete

enables

GO:0000900

translation repressor activity, mRNA regulatory element binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P04818

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3921

F

Seeded From UniProt

complete

enables

GO:1990825

sequence-specific mRNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

F

Seeded From UniProt

complete

involved_in

GO:0046683

response to organophosphorus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

P

Seeded From UniProt

complete

involved_in

GO:0035999

tetrahydrofolate interconversion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

P

Seeded From UniProt

complete

involved_in

GO:0017148

negative regulation of translation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

P

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

C

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

F

Seeded From UniProt

complete

enables

GO:0000900

translation repressor activity, mRNA regulatory element binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04818
ensembl:ENSP00000315644

F

Seeded From UniProt

complete

involved_in

GO:0097421

liver regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0060574

intestinal epithelial cell maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0051593

response to folic acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0048589

developmental growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

enables

GO:0048037

cofactor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

involved_in

GO:0046653

tetrahydrofolate metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0046078

dUMP metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0033189

response to vitamin A

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0032570

response to progesterone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0019860

uracil metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0019088

immortalization of host cell by virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0006417

regulation of translation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

involved_in

GO:0006206

pyrimidine nucleobase metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

C

Seeded From UniProt

complete

enables

GO:0005542

folic acid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45352
ensembl:ENSRNOP00000053086

F

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000398
InterPro:IPR020940

F

Seeded From UniProt

complete

involved_in

GO:0006231

dTMP biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000398
InterPro:IPR020940

P

Seeded From UniProt

complete

enables

GO:0004799

thymidylate synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.45

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

involved_in

GO:0009165

nucleotide biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0545

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

involved_in

GO:0006235

dTTP biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00575

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page