MOUSE:TRPC6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Trpc6 (synonyms: Trp6, Trrp6)
Protein Name(s)	Short transient receptor potential channel 6 TrpC6 Calcium entry channel Transient receptor protein 6 TRP-6
External Links
UniProt	Q61143
EMBL	U49069 AF057748 CH466522 BC141131
CCDS	CCDS22815.1
RefSeq	NP_038866.2 XP_006509913.1
UniGene	Mm.325086
ProteinModelPortal	Q61143
SMR	Q61143
BioGrid	204332
DIP	DIP-60893N
ChEMBL	CHEMBL1795081
GuidetoPHARMACOLOGY	491
PhosphoSite	Q61143
PaxDb	Q61143
PRIDE	Q61143
Ensembl	ENSMUST00000050433
GeneID	22068
KEGG	mmu:22068
UCSC	uc009odl.1
CTD	7225
MGI	MGI:109523
eggNOG	NOG254238
GeneTree	ENSGT00760000119180
HOGENOM	HOG000020590
HOVERGEN	HBG068337
InParanoid	Q61143
KO	K04969
OMA	CSECNQK
OrthoDB	EOG77HDD1
TreeFam	TF313147
Reactome	REACT_219232 REACT_227667 REACT_227861 REACT_230631
NextBio	301892
PRO	PR:Q61143
Proteomes	UP000000589
Bgee	Q61143
Genevestigator	Q61143
GO	GO:0005887 GO:0005886 GO:0036057 GO:0070679 GO:0005216 GO:0015279 GO:0007568 GO:0070301 GO:0071456 GO:0051928 GO:0007204 GO:0032414
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR005821 IPR004729 IPR013555 IPR005462 IPR002153
PANTHER	PTHR10117 PTHR10117:SF7
Pfam	PF12796 PF00520 PF08344
PRINTS	PR01097 PR01647
SMART	SM00248
SUPFAM	SSF48403
TIGRFAMs	TIGR00870
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y210	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y210	F		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109524 MGI:MGI:109525 MGI:MGI:109527 PANTHER:PTN000012230 UniProtKB:P48995 UniProtKB:Q13507 UniProtKB:Q9Y210	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003861 FB:FBgn0005614 PANTHER:PTN000012230 UniProtKB:Q13507	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000012230 UniProtKB:P48995	P		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003861 FB:FBgn0005614 FB:FBgn0032593 PANTHER:PTN000012230	C		Seeded From UniProt	complete
enables	GO:0015279	store-operated calcium channel activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109523 MGI:MGI:109525 MGI:MGI:109527 MGI:MGI:109528 PANTHER:PTN000012230 UniProtKB:Q9UBN4 WB:WBGene00004976	F		Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001298123 WB:WBGene00004976	P		Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349470 PANTHER:PTN000012230	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000012230 RGD:621276 UniProtKB:Q13507 WB:WBGene00004976	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	F		Seeded From UniProt	complete
part_of	GO:0036057	slit diaphragm	PMID:15924139^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:28239) part_of:(CL:0000653)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032414	positive regulation of ion transmembrane transporter activity	PMID:10998353^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	P		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	C		Seeded From UniProt	complete
enables	GO:0015279	store-operated calcium channel activity	PMID:8646775^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:9368034^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9368034^[5]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q13507	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15924139^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000653)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10998353^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:15194687^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	F		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051928	positive regulation of calcium ion transport	PMID:10998353^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y210	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050774	negative regulation of dendrite morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	P		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619788	F		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	F		Seeded From UniProt	complete
involved_in	GO:0050774	negative regulation of dendrite morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	P		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	F		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	F		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N78 ensembl:ENSRNOP00000008905	F		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y210 ensembl:ENSP00000340913	F		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y210 ensembl:ENSP00000340913	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y210 ensembl:ENSP00000340913	F		Seeded From UniProt	complete
involved_in	GO:0032414	positive regulation of ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y210 ensembl:ENSP00000340913	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y210 ensembl:ENSP00000340913	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y210 ensembl:ENSP00000340913	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y210 ensembl:ENSP00000340913	C		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y210 ensembl:ENSP00000340913	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002153 InterPro:IPR005462	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002153 InterPro:IPR005821	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005462	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002153 InterPro:IPR005462	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Reiser, J et al. (2005) TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat. Genet. 37 739-44 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Hofmann, T et al. (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem. J. 351 115-22 PubMed GONUTS page
↑ Zhu, X et al. (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85 661-71 PubMed GONUTS page
↑ ^5.0 ^5.1 Boulay, G et al. (1997) Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J. Biol. Chem. 272 29672-80 PubMed GONUTS page
↑ Hu, HZ et al. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem. 279 35741-8 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15924139-2] 2.0 ^2.1 Reiser, J et al. (2005) TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat. Genet. 37 739-44 PubMed GONUTS page

[PMID:10998353-3] 3.0 ^3.1 ^3.2 Hofmann, T et al. (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem. J. 351 115-22 PubMed GONUTS page

[PMID:8646775-4] Zhu, X et al. (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85 661-71 PubMed GONUTS page

[PMID:9368034-5] 5.0 ^5.1 Boulay, G et al. (1997) Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J. Biol. Chem. 272 29672-80 PubMed GONUTS page

[PMID:15194687-6] Hu, HZ et al. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem. 279 35741-8 PubMed GONUTS page

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MOUSE:TRPC6

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Notes

References

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