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MOUSE:TRPC5
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Trpc5 (synonyms: Trp5, Trrp5) | |
| Protein Name(s) | Short transient receptor potential channel 5
TrpC5 Capacitative calcium entry channel 2 CCE2 Transient receptor protein 5 TRP-5 mTRP5 Trp-related protein 5 | |
| External Links | ||
| UniProt | Q9QX29 | |
| EMBL | AF029983 AF060107 AJ006204 | |
| CCDS | CCDS30457.1 | |
| RefSeq | NP_033454.1 | |
| UniGene | Mm.328378 | |
| ProteinModelPortal | Q9QX29 | |
| SMR | Q9QX29 | |
| BioGrid | 204331 | |
| MINT | MINT-144678 | |
| GuidetoPHARMACOLOGY | 490 | |
| PhosphoSite | Q9QX29 | |
| PRIDE | Q9QX29 | |
| Ensembl | ENSMUST00000040184 | |
| GeneID | 22067 | |
| KEGG | mmu:22067 | |
| UCSC | uc009umv.1 | |
| CTD | 7224 | |
| MGI | MGI:109524 | |
| eggNOG | NOG254238 | |
| GeneTree | ENSGT00760000119180 | |
| HOGENOM | HOG000020589 | |
| HOVERGEN | HBG068337 | |
| InParanoid | Q9QX29 | |
| KO | K04968 | |
| OMA | HPRRSFS | |
| OrthoDB | EOG72G17P | |
| PhylomeDB | Q9QX29 | |
| TreeFam | TF313147 | |
| Reactome | REACT_227861 REACT_230631 | |
| NextBio | 301888 | |
| PRO | PR:Q9QX29 | |
| Proteomes | UP000000589 | |
| Bgee | Q9QX29 | |
| ExpressionAtlas | Q9QX29 | |
| Genevestigator | Q9QX29 | |
| GO | GO:0034704 GO:0005886 GO:0005262 GO:0070679 | |
| Gene3D | 1.25.40.20 | |
| InterPro | IPR002110 IPR020683 IPR005821 IPR004729 IPR013555 IPR005461 IPR002153 | |
| PANTHER | PTHR10117 PTHR10117:SF24 | |
| Pfam | PF00023 PF12796 PF00520 PF08344 | |
| PRINTS | PR01097 PR01646 | |
| SMART | SM00248 | |
| SUPFAM | SSF48403 | |
| TIGRFAMs | TIGR00870 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0090280 |
positive regulation of calcium ion import |
ECO:0000315 |
P |
Fig 1. TRPC5- or TRPC6-depleted cells showed a statistically significant reduction in the peak amplitude of the Ca2+ transients as compared to controls. In the presence of shRNA directed against TRPC5 or TRPC6, the Ca2+ response after addition of 2 mM Ca2+ to the bath was significantly diminished by 60 and 50%, respectively. |
complete | |||||
|
enables |
GO:0070679 |
inositol 1,4,5 trisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070679 |
inositol 1,4,5 trisphosphate binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109524 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070588 |
calcium ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003861 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051480 |
regulation of cytosolic calcium ion concentration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000012230 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034703 |
cation channel complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003861 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015279 |
store-operated calcium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109523 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006828 |
manganese ion transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1349470 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000012230 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1902630 |
regulation of membrane hyperpolarization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050774 |
negative regulation of dendrite morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045773 |
positive regulation of axon extension |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045666 |
positive regulation of neuron differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042805 |
actinin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034704 |
calcium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030276 |
clathrin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005262 |
calcium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:619787 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034704 |
calcium channel complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UL62 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005262 |
calcium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UL62 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902630 |
regulation of membrane hyperpolarization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050774 |
negative regulation of dendrite morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045773 |
positive regulation of axon extension |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045666 |
positive regulation of neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042805 |
actinin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030276 |
clathrin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003779 |
actin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2K149 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005262 |
calcium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070588 |
calcium ion transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005262 |
calcium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070588 |
calcium ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006816 |
calcium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Tian, D et al. (2010) Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal 3 ra77 PubMed GONUTS page
- ↑ Yuan, JP et al. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114 777-89 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0005886 ! plasma membrane
- GO:0045773 ! positive regulation of axon extension
- GO:0045666 ! positive regulation of neuron differentiation
- GO:0010800 ! positive regulation of peptidyl-threonine phosphorylation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0090280 ! positive regulation of calcium ion import
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