MOUSE:TRPC4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Trpc4 (synonyms: Trrp4)
Protein Name(s)	Short transient receptor potential channel 4 TrpC4 Capacitative calcium entry channel Trp4 Receptor-activated cation channel TRP4
External Links
UniProt	Q9QUQ5
EMBL	AF011543 U50922 AF190646 U50921 AF019663 X90697
CCDS	CCDS17350.1
PIR	S59128
RefSeq	NP_001240611.1 NP_058680.1 XP_006501359.1
UniGene	Mm.10100 Mm.489865
ProteinModelPortal	Q9QUQ5
SMR	Q9QUQ5
BioGrid	204330
IntAct	Q9QUQ5
MINT	MINT-144626
BindingDB	Q9QUQ5
ChEMBL	CHEMBL1741219
GuidetoPHARMACOLOGY	489
PhosphoSite	Q9QUQ5
PRIDE	Q9QUQ5
Ensembl	ENSMUST00000029311
GeneID	22066
KEGG	mmu:22066
UCSC	uc008pfd.2 uc008pff.2
CTD	7223
MGI	MGI:109525
eggNOG	NOG254238
GeneTree	ENSGT00760000119180
HOGENOM	HOG000020589
HOVERGEN	HBG068337
InParanoid	Q9QUQ5
KO	K04967
OMA	CKKKIRR
OrthoDB	EOG72G17P
PhylomeDB	Q9QUQ5
TreeFam	TF313147
Reactome	REACT_227861 REACT_230631
NextBio	301884
PRO	PR:Q9QUQ5
Proteomes	UP000000589
Bgee	Q9QUQ5
ExpressionAtlas	Q9QUQ5
Genevestigator	Q9QUQ5
GO	GO:0016323 GO:0034704 GO:0005901 GO:0009986 GO:0005911 GO:0030863 GO:0045121 GO:0005886 GO:0043234 GO:0070679 GO:0015279 GO:0070509 GO:0014051 GO:0048709
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR005821 IPR004729 IPR013555 IPR005460 IPR002153
PANTHER	PTHR10117 PTHR10117:SF25
Pfam	PF00023 PF12796 PF00520 PF08344
PRINTS	PR01097 PR01645
SMART	SM00248
SUPFAM	SSF48403
TIGRFAMs	TIGR00870
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	PMID:14505576^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14505576^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109524 MGI:MGI:109525 MGI:MGI:109527 PANTHER:PTN000012230 UniProtKB:P48995 UniProtKB:Q13507 UniProtKB:Q9Y210	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003861 FB:FBgn0005614 PANTHER:PTN000012230 UniProtKB:Q13507	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000012230 UniProtKB:P48995	P		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003861 FB:FBgn0005614 FB:FBgn0032593 PANTHER:PTN000012230	C		Seeded From UniProt	complete
enables	GO:0015279	store-operated calcium channel activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109523 MGI:MGI:109525 MGI:MGI:109527 MGI:MGI:109528 PANTHER:PTN000012230 UniProtKB:Q9UBN4 WB:WBGene00004976	F		Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349470 PANTHER:PTN000012230	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000012230 RGD:621276 UniProtKB:Q13507 WB:WBGene00004976	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070509	calcium ion import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051924	regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048709	oligodendrocyte differentiation	PMID:19139271^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:17416589^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16728) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17416589^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11881 UniProtKB:P49817 UniProtKB:Q61056	C	part_of:(EMAPA:16728) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0030863	cortical cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	C		Seeded From UniProt	complete
enables	GO:0015279	store-operated calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014051	gamma-aminobutyric acid secretion	PMID:14668438^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387666	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621276	P		Seeded From UniProt	complete
colocalizes_with	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:11897792^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35117)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621276	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10998353^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBN4	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621276	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621276	F		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	F		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	C		Seeded From UniProt	complete
part_of	GO:0030863	cortical cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	C		Seeded From UniProt	complete
enables	GO:0015279	store-operated calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	F		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBN4 ensembl:ENSP00000486109	C		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002153 InterPro:IPR005460	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002153 InterPro:IPR005821	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005460	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002153 InterPro:IPR005460	P		Seeded From UniProt	complete
enables	GO:0015279	store-operated calcium channel activity	PMID:15044151^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000650)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15044151^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000650)	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015279	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yuan, JP et al. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114 777-89 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Gobert, RP et al. (2009) Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol. Cell. Biol. 29 1538-53 PubMed GONUTS page
↑ ^4.0 ^4.1 Murata, T et al. (2007) Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J. Biol. Chem. 282 16631-43 PubMed GONUTS page
↑ Munsch, T et al. (2003) Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc. Natl. Acad. Sci. U.S.A. 100 16065-70 PubMed GONUTS page
↑ Torihashi, S et al. (2002) Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolae. J. Biol. Chem. 277 19191-7 PubMed GONUTS page
↑ Hofmann, T et al. (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem. J. 351 115-22 PubMed GONUTS page
↑ ^8.0 ^8.1 Wang, X et al. (2004) TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells. Am. J. Physiol., Cell Physiol. 287 C357-64 PubMed GONUTS page

[PMID:14505576-1] 1.0 ^1.1 Yuan, JP et al. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114 777-89 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19139271-3] Gobert, RP et al. (2009) Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol. Cell. Biol. 29 1538-53 PubMed GONUTS page

[PMID:17416589-4] 4.0 ^4.1 Murata, T et al. (2007) Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J. Biol. Chem. 282 16631-43 PubMed GONUTS page

[PMID:14668438-5] Munsch, T et al. (2003) Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc. Natl. Acad. Sci. U.S.A. 100 16065-70 PubMed GONUTS page

[PMID:11897792-6] Torihashi, S et al. (2002) Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolae. J. Biol. Chem. 277 19191-7 PubMed GONUTS page

[PMID:10998353-7] Hofmann, T et al. (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem. J. 351 115-22 PubMed GONUTS page

[PMID:15044151-8] 8.0 ^8.1 Wang, X et al. (2004) TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells. Am. J. Physiol., Cell Physiol. 287 C357-64 PubMed GONUTS page

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MOUSE:TRPC4

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