MOUSE:TOR1A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tor1a (synonyms: Dyt1)
Protein Name(s)	Torsin-1A Dystonia 1 protein Torsin ATPase 1 Torsin family 1 member A
External Links
UniProt	Q9ER39
EMBL	AJ298841 BC017683
CCDS	CCDS15891.1
RefSeq	NP_659133.1
UniGene	Mm.154994
ProteinModelPortal	Q9ER39
BioGrid	206008
MINT	MINT-1836416
PhosphoSite	Q9ER39
MaxQB	Q9ER39
PaxDb	Q9ER39
PRIDE	Q9ER39
Ensembl	ENSMUST00000028200
GeneID	30931
KEGG	mmu:30931
UCSC	uc008jdc.2
CTD	1861
MGI	MGI:1353568
eggNOG	NOG283963
GeneTree	ENSGT00390000001920
HOGENOM	HOG000115770
HOVERGEN	HBG054188
InParanoid	Q9ER39
OMA	YFPREER
OrthoDB	EOG7TF791
PhylomeDB	Q9ER39
TreeFam	TF314941
ChiTaRS	Tor1a
NextBio	307342
PRO	PR:Q9ER39
Proteomes	UP000000589
Bgee	Q9ER39
CleanEx	MM_TOR1A
ExpressionAtlas	Q9ER39
Genevestigator	Q9ER39
GO	GO:0030054 GO:0005737 GO:0030659 GO:0005856 GO:0005783 GO:0005788 GO:0070062 GO:0042406 GO:0030426 GO:0005635 GO:0031965 GO:0005634 GO:0030141 GO:0008021 GO:0030133 GO:0005524 GO:0016887 GO:0008092 GO:0051787 GO:0007155 GO:0051085 GO:0061077 GO:0072321 GO:0071712 GO:0045104 GO:0031175 GO:0006998 GO:0071763 GO:0006996 GO:1900244 GO:0000338 GO:0051260 GO:0034504 GO:0051584 GO:2000008 GO:0006979 GO:0048489 GO:0044319
Gene3D	3.40.50.300
InterPro	IPR027417 IPR010448 IPR017378
PANTHER	PTHR10760
Pfam	PF06309
PIRSF	PIRSF038079
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
involved_in	GO:0072321	chaperone-mediated protein transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
involved_in	GO:0071712	ER-associated misfolded protein catabolic process	PMID:17200151^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
enables	GO:0051787	misfolded protein binding	PMID:17200151^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O70258	F		Seeded From UniProt	complete
involved_in	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	PMID:18827015^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042406	extrinsic component of endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	PMID:18827015^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q4FZC9	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q68G38	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q68G38	C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q68G38	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	F		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	PMID:18827015^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QXS1	F		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	PMID:18827015^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20152	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
involved_in	GO:0006996	organelle organization	PMID:18827015^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000338	protein deneddylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072321	chaperone-mediated protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071763	nuclear membrane organization	PMID:20457914^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:3582693	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071763	nuclear membrane organization	PMID:20457914^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1353605	P	occurs_in:(CL:0000057)\|occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071763	nuclear membrane organization	PMID:20457914^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3623421	P	occurs_in:(EMAPA:16894) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071763	nuclear membrane organization	PMID:20080676^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3623421 MGI:MGI:3623422	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061077	chaperone-mediated protein folding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	PMID:20015956^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	PMID:20015956^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048489	synaptic vesicle transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	C		Seeded From UniProt	complete
part_of	GO:0042406	extrinsic component of endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034504	protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	C		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	F		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006998	nuclear envelope organization	PMID:16364897^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3623421 MGI:MGI:3623422	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:20015956^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:20015956^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15767459^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11730696^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628863	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:20457914^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11730696^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000338	protein deneddylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14656	P		Seeded From UniProt	complete
involved_in	GO:2000008	regulation of protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
involved_in	GO:0072321	chaperone-mediated protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
involved_in	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C		Seeded From UniProt	complete
part_of	GO:0042406	extrinsic component of endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	C		Seeded From UniProt	complete
involved_in	GO:0000338	protein deneddylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14656 ensembl:ENSP00000345719	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	C		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	C		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q68G38 ensembl:ENSRNOP00000063691	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010448 InterPro:IPR017378 InterPro:IPR030549	F		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017378	C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	C		Seeded From UniProt	complete
involved_in	GO:0006998	nuclear envelope organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	F		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P		Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	F		Seeded From UniProt	complete
involved_in	GO:0051085	chaperone cofactor-dependent protein refolding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017378	P		Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P		Seeded From UniProt	complete
involved_in	GO:0072321	chaperone-mediated protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030549	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0771 UniProtKB-SubCell:SL-0261	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0244	C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0096	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0259	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Esapa, CT et al. (2007) SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA. Hum. Mol. Genet. 16 327-42 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nery, FC et al. (2008) TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. J. Cell. Sci. 121 3476-86 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Kim, CE et al. (2010) A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc. Natl. Acad. Sci. U.S.A. 107 9861-6 PubMed GONUTS page
↑ An, JY et al. (2010) UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 107 1912-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Jungwirth, M et al. (2010) Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA. Hum. Mol. Genet. 19 888-900 PubMed GONUTS page
↑ Goodchild, RE et al. (2005) Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Neuron 48 923-32 PubMed GONUTS page
↑ Goodchild, RE & Dauer, WT (2005) The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein. J. Cell Biol. 168 855-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Konakova, M & Pulst, SM (2001) Immunocytochemical characterization of torsin proteins in mouse brain. Brain Res. 922 1-8 PubMed GONUTS page

[PMID:17200151-1] 1.0 ^1.1 Esapa, CT et al. (2007) SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA. Hum. Mol. Genet. 16 327-42 PubMed GONUTS page

[PMID:18827015-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nery, FC et al. (2008) TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. J. Cell. Sci. 121 3476-86 PubMed GONUTS page

[PMID:20457914-3] 3.0 ^3.1 ^3.2 ^3.3 Kim, CE et al. (2010) A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc. Natl. Acad. Sci. U.S.A. 107 9861-6 PubMed GONUTS page

[PMID:20080676-4] An, JY et al. (2010) UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 107 1912-7 PubMed GONUTS page

[PMID:20015956-5] 5.0 ^5.1 ^5.2 ^5.3 Jungwirth, M et al. (2010) Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA. Hum. Mol. Genet. 19 888-900 PubMed GONUTS page

[PMID:16364897-6] Goodchild, RE et al. (2005) Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Neuron 48 923-32 PubMed GONUTS page

[PMID:15767459-7] Goodchild, RE & Dauer, WT (2005) The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein. J. Cell Biol. 168 855-62 PubMed GONUTS page

[PMID:11730696-8] 8.0 ^8.1 Konakova, M & Pulst, SM (2001) Immunocytochemical characterization of torsin proteins in mouse brain. Brain Res. 922 1-8 PubMed GONUTS page

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MOUSE:TOR1A

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