MOUSE:TNNI3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tnni3
Protein Name(s)	Troponin I, cardiac muscle Cardiac troponin I
External Links
UniProt	P48787
EMBL	Z22784 U09181 BC061171
CCDS	CCDS39736.1
PIR	A53805
RefSeq	NP_033432.1
UniGene	Mm.27674
PDB	2JPW
PDBsum	2JPW
ProteinModelPortal	P48787
SMR	P48787
BioGrid	204266
IntAct	P48787
MINT	MINT-4138144
STRING	10090.ENSMUSP00000096458
PhosphoSite	P48787
MaxQB	P48787
PaxDb	P48787
PRIDE	P48787
Ensembl	ENSMUST00000098859
GeneID	21954
KEGG	mmu:21954
UCSC	uc009exv.1
CTD	7137
MGI	MGI:98783
eggNOG	NOG270363
HOGENOM	HOG000293300
HOVERGEN	HBG052737
InParanoid	P48787
KO	K12044
OMA	INQLTIQ
OrthoDB	EOG71G9WD
PhylomeDB	P48787
TreeFam	TF313374
Reactome	REACT_232053
EvolutionaryTrace	P48787
NextBio	301628
PRO	PR:P48787
Proteomes	UP000000589
Bgee	P48787
CleanEx	MM_TNNI3
ExpressionAtlas	P48787
Genevestigator	P48787
GO	GO:0005737 GO:0030017 GO:0005861 GO:0019855 GO:0046872 GO:0060048 GO:0006874 GO:0007507 GO:0032780 GO:0006937 GO:0006940 GO:0001980 GO:0006941 GO:0001570 GO:0055010
InterPro	IPR001978 IPR021666
Pfam	PF00992 PF11636

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060048	cardiac muscle contraction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001011175 RGD:62052 UniProtKB:P19429	P		Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000348305 WB:WBGene00006585	P		Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000348305 RGD:62050 RGD:621765 UniProtKB:P19429 UniProtKB:P48788	C		Seeded From UniProt	complete
involved_in	GO:0003009	skeletal muscle contraction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001011175 UniProtKB:P48788	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:11158984^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:11356618^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15601779^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23693	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions	PMID:11158984^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:15611140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990584	cardiac Troponin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	C		Seeded From UniProt	complete
part_of	GO:0097512	cardiac myofibril	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060048	cardiac muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060048	cardiac muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62052	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060047	heart contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	F		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62052	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032780	negative regulation of ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	P		Seeded From UniProt	complete
enables	GO:0031014	troponin T binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	F		Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	F		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	PMID:16481394^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17339) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	PMID:15601779^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23693	C		Seeded From UniProt	complete
part_of	GO:0030016	myofibril	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62052	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	F		Seeded From UniProt	complete
enables	GO:0019855	calcium channel inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:15611140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006941	striated muscle contraction	PMID:11356618^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006941	striated muscle contraction	PMID:10642551^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006940	regulation of smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62052	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006937	regulation of muscle contraction	PMID:12551921^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990584	cardiac Troponin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	C		Seeded From UniProt	complete
part_of	GO:0097512	cardiac myofibril	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	C		Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P		Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F		Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P		Seeded From UniProt	complete
enables	GO:0031014	troponin T binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F		Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F		Seeded From UniProt	complete
enables	GO:0019855	calcium channel inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F		Seeded From UniProt	complete
involved_in	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	P		Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19429 ensembl:ENSP00000341838	F		Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	P		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	C		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	C		Seeded From UniProt	complete
part_of	GO:0030016	myofibril	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	C		Seeded From UniProt	complete
involved_in	GO:0006940	regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	C		Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001978	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 MacGowan, GA et al. (2001) Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites. Am. J. Physiol. Heart Circ. Physiol. 280 H835-43 PubMed GONUTS page
↑ ^3.0 ^3.1 Kögler, H et al. (2001) Maintained contractile reserve in a transgenic mouse model of myocardial stunning. Am. J. Physiol. Heart Circ. Physiol. 280 H2623-30 PubMed GONUTS page
↑ ^4.0 ^4.1 Kedar, V et al. (2004) Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc. Natl. Acad. Sci. U.S.A. 101 18135-40 PubMed GONUTS page
↑ ^5.0 ^5.1 Barbato, JC et al. (2005) Proteolytic N-terminal truncation of cardiac troponin I enhances ventricular diastolic function. J. Biol. Chem. 280 6602-9 PubMed GONUTS page
↑ Bennett, PM et al. (2006) The transitional junction: a new functional subcellular domain at the intercalated disc. Mol. Biol. Cell 17 2091-100 PubMed GONUTS page
↑ Murphy, AM et al. (2000) Transgenic mouse model of stunned myocardium. Science 287 488-91 PubMed GONUTS page
↑ Burkart, EM et al. (2003) Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J. Biol. Chem. 278 11265-72 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11158984-2] 2.0 ^2.1 MacGowan, GA et al. (2001) Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites. Am. J. Physiol. Heart Circ. Physiol. 280 H835-43 PubMed GONUTS page

[PMID:11356618-3] 3.0 ^3.1 Kögler, H et al. (2001) Maintained contractile reserve in a transgenic mouse model of myocardial stunning. Am. J. Physiol. Heart Circ. Physiol. 280 H2623-30 PubMed GONUTS page

[PMID:15601779-4] 4.0 ^4.1 Kedar, V et al. (2004) Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc. Natl. Acad. Sci. U.S.A. 101 18135-40 PubMed GONUTS page

[PMID:15611140-5] 5.0 ^5.1 Barbato, JC et al. (2005) Proteolytic N-terminal truncation of cardiac troponin I enhances ventricular diastolic function. J. Biol. Chem. 280 6602-9 PubMed GONUTS page

[PMID:16481394-6] Bennett, PM et al. (2006) The transitional junction: a new functional subcellular domain at the intercalated disc. Mol. Biol. Cell 17 2091-100 PubMed GONUTS page

[PMID:10642551-7] Murphy, AM et al. (2000) Transgenic mouse model of stunned myocardium. Science 287 488-91 PubMed GONUTS page

[PMID:12551921-8] Burkart, EM et al. (2003) Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J. Biol. Chem. 278 11265-72 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

MOUSE:TNNI3

Contents

Annotations

Notes

References

a

c

e

g

h

i

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools