MOUSE:TERT

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tert
Protein Name(s)	Telomerase reverse transcriptase Telomerase catalytic subunit
External Links
UniProt	O70372
EMBL	AF051911 AF073311 AF247818 AF029235
CCDS	CCDS26633.1
RefSeq	NP_033380.1
UniGene	Mm.10109
BioGrid	204118
DIP	DIP-60451N
PhosphoSite	O70372
PaxDb	O70372
PRIDE	O70372
Ensembl	ENSMUST00000022104
GeneID	21752
KEGG	mmu:21752
UCSC	uc007rdq.1
CTD	7015
MGI	MGI:1202709
eggNOG	NOG276584
GeneTree	ENSGT00390000018531
HOGENOM	HOG000148780
HOVERGEN	HBG000460
InParanoid	O70372
KO	K11126
OMA	RACFYAT
OrthoDB	EOG744TB3
PhylomeDB	O70372
TreeFam	TF329048
Reactome	REACT_216539 REACT_262572
NextBio	301049
PRO	PR:O70372
Proteomes	UP000000589
Bgee	O70372
CleanEx	MM_TERT
ExpressionAtlas	O70372
Genevestigator	O70372
GO	GO:0000781 GO:0005739 GO:0005730 GO:0016605 GO:0005697 GO:0003677 GO:0046872 GO:0003720 GO:0070034 GO:0003721 GO:0001223 GO:0022616 GO:2001240 GO:0042635 GO:2000648 GO:0030177 GO:0090399 GO:0032203 GO:0007004
InterPro	IPR000477 IPR021891 IPR003545
Pfam	PF00078 PF12009
PRINTS	PR01365
SMART	SM00975
PROSITE	PS50878

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005697	telomerase holoenzyme complex	PMID:22496369^[1]	ECO:0000314			C		In figure 8, it shows that p73 promoters represses the TERT complex.	complete CACAO 4837
	GO:0000781	chromosome, telomeric region	PMID:21113150^[2]	ECO:0000314			C		Figure 1. Localization of telomeric region by fluorescence	complete
part_of	GO:0005697	telomerase holoenzyme complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:16507993^[3]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004416C5_9606	F		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:16507993^[3]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS00004A7003_9606	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:16037417^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	PMID:19571879^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q3TKT4	F		Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	PMID:16037417^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000428)	Seeded From UniProt	complete
involved_in	GO:0042635	positive regulation of hair cycle	PMID:16107853^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	PMID:16107853^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000428)	Seeded From UniProt	complete
involved_in	GO:0042635	positive regulation of hair cycle	PMID:16037417^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21937513^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	PMID:19571879^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O88566	P		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202709 PANTHER:PTN000249074 PomBase:SPBC29A3.14c UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000249074 SGD:S000004310	F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000249074 PomBase:SPBC29A3.14c SGD:S000004310 TAIR:locus:2148975 UniProtKB:A0A1D8PEA0 UniProtKB:O14746 UniProtKB:Q8IEH2 WB:WBGene00006618	P		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000249074 PomBase:SPBC29A3.14c UniProtKB:A0A1D8PEA0 UniProtKB:O14746 UniProtKB:Q1PS67	F		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202709 PANTHER:PTN000249074 PomBase:SPBC29A3.14c SGD:S000004310 UniProtKB:A0A1D8PEA0 UniProtKB:O14746 UniProtKB:Q1PS67	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000773	negative regulation of cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
part_of	GO:1990572	TERT-RMRP complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904751	positive regulation of protein localization to nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903704	negative regulation of production of siRNA involved in RNA interference	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903620	positive regulation of transdifferentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
enables	GO:0098680	template-free RNA nucleotidyltransferase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090399	replicative senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071897	DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070200	establishment of protein localization to telomere	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0062103	double-stranded RNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060253	negative regulation of glial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046326	positive regulation of glucose import	PMID:24970747^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031647	regulation of protein stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
part_of	GO:0031379	RNA-directed RNA polymerase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030422	production of siRNA involved in RNA interference	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022616	DNA strand elongation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007004	telomere maintenance via telomerase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006278	RNA-dependent DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24970747^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000056)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24970747^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000056)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
part_of	GO:0005697	telomerase holoenzyme complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70494	C		Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:14701760^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001172	transcription, RNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	C		Seeded From UniProt	complete
enables	GO:0000049	tRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14746	F		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
part_of	GO:1990572	TERT-RMRP complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
involved_in	GO:1904751	positive regulation of protein localization to nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:1903704	negative regulation of production of siRNA involved in RNA interference	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
enables	GO:0098680	template-free RNA nucleotidyltransferase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
involved_in	GO:0090399	replicative senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:0070200	establishment of protein localization to telomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
enables	GO:0070034	telomerase RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
involved_in	GO:0062103	double-stranded RNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
part_of	GO:0031379	RNA-directed RNA polymerase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:0022616	DNA strand elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
involved_in	GO:0006278	RNA-dependent DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
part_of	GO:0005697	telomerase holoenzyme complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
part_of	GO:0000333	telomerase catalytic core complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	C		Seeded From UniProt	complete
enables	GO:0000049	tRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14746 ensembl:ENSP00000309572	F		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:1903620	positive regulation of transdifferentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0060253	negative regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q673L6 ensembl:ENSRNOP00000022683	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003545	F		Seeded From UniProt	complete
enables	GO:0003721	telomerase RNA reverse transcriptase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003545	F		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR021891	F		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.49	F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:16107853^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003720	telomerase activity	PMID:16107853^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	part_of:(GO:0007004)	Seeded From UniProt	complete
involved_in	GO:1904173	regulation of histone demethylase activity (H3-K4 specific)	PMID:22723415^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:Q91X20)	Seeded From UniProt	complete
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F		Seeded From UniProt	complete
enables	GO:0003964	RNA-directed DNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0695	F		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yao, Y et al. (2012) Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression. J. Biol. Chem. 287 20737-47 PubMed GONUTS page
↑ Jaskelioff, M et al. (2011) Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469 102-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Middleman, EJ et al. (2006) Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Mol. Cell. Biol. 26 2146-59 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Flores, I et al. (2005) Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309 1253-6 PubMed GONUTS page
↑ ^5.0 ^5.1 Park, JI et al. (2009) Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460 66-72 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Sarin, KY et al. (2005) Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436 1048-52 PubMed GONUTS page
↑ Sharma, NK et al. (2012) Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 40 712-25 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Shaheen, F et al. (2014) Extra-nuclear telomerase reverse transcriptase (TERT) regulates glucose transport in skeletal muscle cells. Biochim. Biophys. Acta 1842 1762-9 PubMed GONUTS page
↑ Hunt, CR et al. (2004) Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol. Cell. Biol. 24 899-911 PubMed GONUTS page
↑ Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page

[PMID:22496369-1] Yao, Y et al. (2012) Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression. J. Biol. Chem. 287 20737-47 PubMed GONUTS page

[PMID:21113150-2] Jaskelioff, M et al. (2011) Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469 102-6 PubMed GONUTS page

[PMID:16507993-3] 3.0 ^3.1 Middleman, EJ et al. (2006) Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Mol. Cell. Biol. 26 2146-59 PubMed GONUTS page

[PMID:16037417-4] 4.0 ^4.1 ^4.2 Flores, I et al. (2005) Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309 1253-6 PubMed GONUTS page

[PMID:19571879-5] 5.0 ^5.1 Park, JI et al. (2009) Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460 66-72 PubMed GONUTS page

[PMID:16107853-6] 6.0 ^6.1 ^6.2 ^6.3 Sarin, KY et al. (2005) Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436 1048-52 PubMed GONUTS page

[PMID:21937513-7] Sharma, NK et al. (2012) Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 40 712-25 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24970747-9] 9.0 ^9.1 ^9.2 Shaheen, F et al. (2014) Extra-nuclear telomerase reverse transcriptase (TERT) regulates glucose transport in skeletal muscle cells. Biochim. Biophys. Acta 1842 1762-9 PubMed GONUTS page

[PMID:14701760-10] Hunt, CR et al. (2004) Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol. Cell. Biol. 24 899-911 PubMed GONUTS page

[PMID:22723415-11] Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page

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