MOUSE:SYT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Syt1
Protein Name(s)	Synaptotagmin-1 Synaptotagmin I SytI p65
External Links
UniProt	P46096
EMBL	D37792 AK078790 BC042519
CCDS	CCDS24163.1
RefSeq	NP_001239270.1 NP_001239271.1 NP_033332.1 XP_006513509.1 XP_006513510.1 XP_006513511.1
UniGene	Mm.289702 Mm.489829
ProteinModelPortal	P46096
SMR	P46096
BioGrid	203611
DIP	DIP-31322N
IntAct	P46096
MINT	MINT-4136555
STRING	10090.ENSMUSP00000100912
TCDB	9.A.48.1.1
PhosphoSite	P46096
MaxQB	P46096
PaxDb	P46096
PRIDE	P46096
Ensembl	ENSMUST00000064054 ENSMUST00000105276
GeneID	20979
KEGG	mmu:20979
UCSC	uc007gzg.2
CTD	6857
MGI	MGI:99667
eggNOG	COG5038
GeneTree	ENSGT00760000118973
HOGENOM	HOG000232127
HOVERGEN	HBG005010
InParanoid	P46096
KO	K15290
OMA	HDIIGEY
OrthoDB	EOG78PV8W
PhylomeDB	P46096
TreeFam	TF315600
Reactome	REACT_205038 REACT_229514 REACT_242222 REACT_245631
ChiTaRS	Syt1
NextBio	299964
PRO	PR:P46096
Proteomes	UP000000589
Bgee	P46096
CleanEx	MM_SYT1
ExpressionAtlas	P46096
Genevestigator	P46096
GO	GO:0030054 GO:0042584 GO:0031045 GO:0060076 GO:0016021 GO:0043005 GO:0005886 GO:0042734 GO:0030141 GO:0031201 GO:0008021 GO:0030672 GO:0005509 GO:0005544 GO:0048306 GO:0050750 GO:0005546 GO:0001786 GO:0000149 GO:0017075 GO:0005215 GO:0098746 GO:0007269 GO:0045956 GO:0050806 GO:0031340 GO:1903305 GO:0051966 GO:0051592 GO:0016079 GO:0048278
Gene3D	2.60.40.150
InterPro	IPR000008 IPR001565 IPR015428
PANTHER	PTHR10024:SF183
Pfam	PF00168
PRINTS	PR00360 PR00399
SMART	SM00239
SUPFAM	SSF49562
PROSITE	PS50004

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0017158	regulation of calcium ion-dependent exocytosis	PMID:11562488^[1]	ECO:0000315			P		Fig 2 & Fig 4. Figure 2D. shows a decrease in the exocytotic burst amplitude of SYT1 mutants.	complete CACAO 5598
involved_in	GO:1903235	positive regulation of calcium ion-dependent exocytosis of neurotransmitter	PMID:11242035^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21576241^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000700)	Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	PMID:21576241^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(GO:0033267)	Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	PMID:18468511^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000007)	Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:8626542^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:18303)\|has_direct_input:(CHEBI:28874)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21707	P		Seeded From UniProt	complete
involved_in	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	PMID:9194562^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0017158	regulation of calcium ion-dependent exocytosis	PMID:11562488^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21707	F		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21707	F	occurs_in:(UBERON:0000955) part_of:(GO:0071277)	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21707	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:1903305	regulation of regulated secretory pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21707	P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
involved_in	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	PMID:7954835^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:12526776^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	PMID:12526776^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	PMID:7954835^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21307259^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002609)	Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	PMID:18703708^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:15774481^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00262	F		Seeded From UniProt	complete
involved_in	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	PMID:7954835^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	PMID:7954835^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	PMID:7954835^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	PMID:7954835^[7]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	PMID:7954835^[7]	ECO:0000279	western blot evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:7954835^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:7954835^[7]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:7954835^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:7954835^[7]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:7954835^[7]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000001283 RGD:3803	P		Seeded From UniProt	complete
part_of	GO:0070382	exocytic vesicle	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859546 PANTHER:PTN000001284 RGD:68397	C		Seeded From UniProt	complete
involved_in	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 PANTHER:PTN000797569	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 PANTHER:PTN000797569	P		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926368 MGI:MGI:99667 PANTHER:PTN000740739 RGD:3803 WB:WBGene00004922	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99667 PANTHER:PTN000740739 RGD:3803	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000740739	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000001283 RGD:3803 RGD:3805 RGD:3806 RGD:68397 RGD:68399 UniProtKB:Q5T7P8	F		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000797569 RGD:3803 RGD:3804 RGD:3806 RGD:68399	F		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000797569 RGD:3803 RGD:3804 RGD:3806	F		Seeded From UniProt	complete
involved_in	GO:0017158	regulation of calcium ion-dependent exocytosis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101759 MGI:MGI:1859545 MGI:MGI:1859546 MGI:MGI:1926368 MGI:MGI:1926373 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 RGD:3805 RGD:62013 RGD:621169 RGD:68397	P		Seeded From UniProt	complete
involved_in	GO:0017156	calcium ion regulated exocytosis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000001283 RGD:62013	P		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 MGI:MGI:1933945 PANTHER:PTN000001284	P		Seeded From UniProt	complete
involved_in	GO:0016079	synaptic vesicle exocytosis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99667 PANTHER:PTN000797569	P		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101759 MGI:MGI:1859545 MGI:MGI:99667 PANTHER:PTN000001283	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261089 MGI:MGI:101759 MGI:MGI:1859544 MGI:MGI:99666 PANTHER:PTN000001284 RGD:3803 RGD:62013 UniProtKB:Q9H2B2	C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:101759 MGI:MGI:1859544 MGI:MGI:1859545 MGI:MGI:1926368 MGI:MGI:99665 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 RGD:3804 RGD:3805 RGD:3806 RGD:62013 RGD:62042 RGD:68397 RGD:68399 UniProtKB:Q5T7P8	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:101759 MGI:MGI:1859544 MGI:MGI:1859545 MGI:MGI:1926368 MGI:MGI:99665 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 RGD:3804 RGD:3805 RGD:3806 RGD:62013	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 MGI:MGI:101759 MGI:MGI:1859546 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 UniProtKB:O00445	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 MGI:MGI:101759 MGI:MGI:1859546 MGI:MGI:99666 MGI:MGI:99667 PANTHER:PTN000001283 RGD:3803 RGD:62042 RGD:68397 UniProtKB:O00445	F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:1859544 MGI:MGI:1859545 MGI:MGI:1859546 MGI:MGI:1926368 MGI:MGI:1926373 MGI:MGI:99666 PANTHER:PTN000001283 RGD:3803 RGD:3805 RGD:68397	F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:1859544 MGI:MGI:1859545 MGI:MGI:1859546 MGI:MGI:1926368 MGI:MGI:1926373 MGI:MGI:99666 PANTHER:PTN000001283 RGD:3803 RGD:3805	F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004242 FB:FBgn0028400 MGI:MGI:1859545 MGI:MGI:1859546 MGI:MGI:1859547 MGI:MGI:1926368 MGI:MGI:1926373 PANTHER:PTN000001283 RGD:3803 RGD:3805 RGD:68397	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903861	positive regulation of dendrite extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903305	regulation of regulated secretory pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071911	synchronous neurotransmitter secretion	PMID:21521611^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071277	cellular response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
enables	GO:0061891	calcium ion sensor activity	PMID:21521611^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061669	spontaneous neurotransmitter secretion	PMID:21521611^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857252	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051592	response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:15082773^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21579	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	PMID:21521611^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857252	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048278	vesicle docking	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045956	positive regulation of calcium ion-dependent exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
part_of	GO:0043229	intracellular organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:15197251^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:14622145^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:15197251^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031340	positive regulation of vesicle fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
colocalizes_with	GO:0031201	SNARE complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21707	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	PMID:15071120^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
enables	GO:0030348	syntaxin-3 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:12145198^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017158	regulation of calcium ion-dependent exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016079	synaptic vesicle exocytosis	PMID:21040848^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857252	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:17360631^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:16407767^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007269	neurotransmitter secretion	PMID:15197251^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:14622145^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21579	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21707	C		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0005513	detection of calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:15197251^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3803	F		Seeded From UniProt	complete
involved_in	GO:1903861	positive regulation of dendrite extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21579 ensembl:ENSP00000261205	P		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21579 ensembl:ENSP00000261205	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21579 ensembl:ENSP00000261205	C		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
involved_in	GO:1903305	regulation of regulated secretory pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
involved_in	GO:0048278	vesicle docking	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
involved_in	GO:0045956	positive regulation of calcium ion-dependent exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
part_of	GO:0043229	intracellular organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
part_of	GO:0031201	SNARE complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
enables	GO:0030348	syntaxin-3 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
involved_in	GO:0017158	regulation of calcium ion-dependent exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	C		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
involved_in	GO:0005513	detection of calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21707 ensembl:ENSRNOP00000069194	F		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015428	F		Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015428	P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015428	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001565	C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:15466855^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15466855^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005544	calcium-dependent phospholipid binding	PMID:12801916^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0260	C		Seeded From UniProt	complete
part_of	GO:0042584	chromaffin granule membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0062	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Voets, T et al. (2001) Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I. Proc. Natl. Acad. Sci. U.S.A. 98 11680-5 PubMed GONUTS page
↑ Fernández-Chacón, R et al. (2001) Synaptotagmin I functions as a calcium regulator of release probability. Nature 410 41-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Mendez, JA et al. (2011) Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels. J. Biol. Chem. 286 23928-37 PubMed GONUTS page
↑ Hu, ZT et al. (2008) Synaptotagmin IV regulates dense core vesicle (DCV) release in LbetaT2 cells. Biochem. Biophys. Res. Commun. 371 781-6 PubMed GONUTS page
↑ Fukuda, M et al. (1996) Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV. J. Biol. Chem. 271 8430-4 PubMed GONUTS page
↑ Geppert, M et al. (1997) The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature 387 810-4 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Geppert, M et al. (1994) Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell 79 717-27 PubMed GONUTS page
↑ ^8.0 ^8.1 Shin, OH et al. (2003) Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Neuron 37 99-108 PubMed GONUTS page
↑ Piccoli, G et al. (2011) LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J. Neurosci. 31 2225-37 PubMed GONUTS page
↑ Gerber, SH et al. (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321 1507-10 PubMed GONUTS page
↑ Hutt, DM et al. (2005) Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction. J. Biol. Chem. 280 20197-203 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Pang, ZP et al. (2011) Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism. Neuron 70 244-51 PubMed GONUTS page
↑ Marschang, P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol. Cell. Biol. 24 3782-93 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Zhang, Q et al. (2004) Synaptotagmin IV regulates glial glutamate release. Proc. Natl. Acad. Sci. U.S.A. 101 9441-6 PubMed GONUTS page
↑ ^16.0 ^16.1 Dandoy-Dron, F et al. (2003) Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells. Eur. J. Neurosci. 18 2449-59 PubMed GONUTS page
↑ Gitler, D et al. (2004) Molecular determinants of synapsin targeting to presynaptic terminals. J. Neurosci. 24 3711-20 PubMed GONUTS page
↑ Quetglas, S et al. (2002) Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis. EMBO J. 21 3970-9 PubMed GONUTS page
↑ Burgalossi, A et al. (2010) SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. Neuron 68 473-87 PubMed GONUTS page
↑ Ikegami, K et al. (2007) Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc. Natl. Acad. Sci. U.S.A. 104 3213-8 PubMed GONUTS page
↑ Fukuda, M (2006) Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport 17 179-82 PubMed GONUTS page
↑ ^22.0 ^22.1 Lazzell, DR et al. (2004) SV2B regulates synaptotagmin 1 by direct interaction. J. Biol. Chem. 279 52124-31 PubMed GONUTS page
↑ Fukuda, M (2003) Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. J. Biochem. 133 641-9 PubMed GONUTS page

[PMID:11562488-1] 1.0 ^1.1 Voets, T et al. (2001) Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I. Proc. Natl. Acad. Sci. U.S.A. 98 11680-5 PubMed GONUTS page

[PMID:11242035-2] Fernández-Chacón, R et al. (2001) Synaptotagmin I functions as a calcium regulator of release probability. Nature 410 41-9 PubMed GONUTS page

[PMID:21576241-3] 3.0 ^3.1 Mendez, JA et al. (2011) Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels. J. Biol. Chem. 286 23928-37 PubMed GONUTS page

[PMID:18468511-4] Hu, ZT et al. (2008) Synaptotagmin IV regulates dense core vesicle (DCV) release in LbetaT2 cells. Biochem. Biophys. Res. Commun. 371 781-6 PubMed GONUTS page

[PMID:8626542-5] Fukuda, M et al. (1996) Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV. J. Biol. Chem. 271 8430-4 PubMed GONUTS page

[PMID:9194562-6] Geppert, M et al. (1997) The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature 387 810-4 PubMed GONUTS page

[PMID:7954835-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Geppert, M et al. (1994) Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell 79 717-27 PubMed GONUTS page

[PMID:12526776-8] 8.0 ^8.1 Shin, OH et al. (2003) Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Neuron 37 99-108 PubMed GONUTS page

[PMID:21307259-9] Piccoli, G et al. (2011) LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J. Neurosci. 31 2225-37 PubMed GONUTS page

[PMID:18703708-10] Gerber, SH et al. (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321 1507-10 PubMed GONUTS page

[PMID:15774481-11] Hutt, DM et al. (2005) Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction. J. Biol. Chem. 280 20197-203 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21521611-13] 13.0 ^13.1 ^13.2 ^13.3 Pang, ZP et al. (2011) Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism. Neuron 70 244-51 PubMed GONUTS page

[PMID:15082773-14] Marschang, P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol. Cell. Biol. 24 3782-93 PubMed GONUTS page

[PMID:15197251-15] 15.0 ^15.1 ^15.2 ^15.3 Zhang, Q et al. (2004) Synaptotagmin IV regulates glial glutamate release. Proc. Natl. Acad. Sci. U.S.A. 101 9441-6 PubMed GONUTS page

[PMID:14622145-16] 16.0 ^16.1 Dandoy-Dron, F et al. (2003) Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells. Eur. J. Neurosci. 18 2449-59 PubMed GONUTS page

[PMID:15071120-17] Gitler, D et al. (2004) Molecular determinants of synapsin targeting to presynaptic terminals. J. Neurosci. 24 3711-20 PubMed GONUTS page

[PMID:12145198-18] Quetglas, S et al. (2002) Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis. EMBO J. 21 3970-9 PubMed GONUTS page

[PMID:21040848-19] Burgalossi, A et al. (2010) SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. Neuron 68 473-87 PubMed GONUTS page

[PMID:17360631-20] Ikegami, K et al. (2007) Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc. Natl. Acad. Sci. U.S.A. 104 3213-8 PubMed GONUTS page

[PMID:16407767-21] Fukuda, M (2006) Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport 17 179-82 PubMed GONUTS page

[PMID:15466855-22] 22.0 ^22.1 Lazzell, DR et al. (2004) SV2B regulates synaptotagmin 1 by direct interaction. J. Biol. Chem. 279 52124-31 PubMed GONUTS page

[PMID:12801916-23] Fukuda, M (2003) Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. J. Biochem. 133 641-9 PubMed GONUTS page

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MOUSE:SYT1

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