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MOUSE:SUFU

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Sufu
Protein Name(s) Suppressor of fused homolog
External Links
UniProt Q9Z0P7
EMBL AF134893
AJ131692
AJ308625
AJ308626
AJ308627
AJ308628
AJ308629
AJ308630
AJ308632
AJ308634
AJ308635
AJ308633
AJ308631
AK015885
AK047603
BC048168
BC056997
CCDS CCDS29879.1
CCDS38008.1
RefSeq NP_001020562.1
NP_056567.2
UniGene Mm.41210
ProteinModelPortal Q9Z0P7
SMR Q9Z0P7
BioGrid 204881
IntAct Q9Z0P7
PhosphoSite Q9Z0P7
MaxQB Q9Z0P7
PaxDb Q9Z0P7
PRIDE Q9Z0P7
Ensembl ENSMUST00000039922
ENSMUST00000111867
ENSMUST00000120778
GeneID 24069
KEGG mmu:24069
UCSC uc008htn.1
uc008hto.1
uc008htq.1
CTD 51684
MGI MGI:1345643
eggNOG NOG72477
GeneTree ENSGT00390000009747
HOGENOM HOG000007864
HOVERGEN HBG061539
InParanoid Q9Z0P7
KO K06229
OMA GDTAITF
OrthoDB EOG7RV9FV
PhylomeDB Q9Z0P7
TreeFam TF324548
Reactome REACT_268522
REACT_268705
REACT_269412
REACT_270923
NextBio 304049
PRO PR:Q9Z0P7
Proteomes UP000000589
Bgee Q9Z0P7
CleanEx MM_SUFU
ExpressionAtlas Q9Z0P7
Genevestigator Q9Z0P7
GO GO:0005929
GO:0005737
GO:0005634
GO:0072372
GO:0008013
GO:0008134
GO:0042994
GO:0007368
GO:0001947
GO:2000059
GO:0045879
GO:1901621
GO:0000122
GO:0001843
GO:0043588
GO:0021776
GO:0021775
GO:0021513
InterPro IPR020941
IPR024314
IPR007768
IPR016591
PANTHER PTHR10928
Pfam PF05076
PF12470
PIRSF PIRSF011844

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005929

cilium

PMID:21209331[1]

ECO:0000314

C

Fig 4A shows ciliary localisation in WT

complete
CACAO 2900

involved_in

GO:0045879

negative regulation of smoothened signaling pathway

PMID:27234298[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:21209331[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:21209331[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20360384[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005355
PANTHER:PTN000859153

P

Seeded From UniProt

complete

involved_in

GO:0042994

cytoplasmic sequestering of transcription factor

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345643
PANTHER:PTN000859153

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005355
PANTHER:PTN000859153
UniProtKB:Q9UMX1

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005355
MGI:MGI:1345643
PANTHER:PTN000859153
UniProtKB:Q8QG94
UniProtKB:Q9UMX1

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345643
PANTHER:PTN000859153
UniProtKB:Q8QG94
UniProtKB:Q9UMX1

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000059

negative regulation of ubiquitin-dependent protein catabolic process

PMID:19684112[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1343085

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901621

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

PMID:19684112[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4840420

P

regulates_o_occurs_in:(EMAPA:16530)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060976

coronary vasculature development

PMID:25807483[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045879

negative regulation of smoothened signaling pathway

PMID:18488998[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045879

negative regulation of smoothened signaling pathway

PMID:16459298[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3619046

P

regulates_o_occurs_in:(EMAPA:16166)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045879

negative regulation of smoothened signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX1

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043588

skin development

PMID:16459298[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3619046

P

results_in_development_of:(EMAPA:17528)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042994

cytoplasmic sequestering of transcription factor

PMID:16316410[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95727
MGI:MGI:95728

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035904

aorta development

PMID:25807483[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021776

smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

PMID:19684112[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4840420

P

  • occurs_in:(EMAPA:16530)
  • occurs_in:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021775

smoothened signaling pathway involved in ventral spinal cord interneuron specification

PMID:19684112[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4840420

P

  • occurs_in:(EMAPA:16530)
  • occurs_in:(CL:0000099)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021513

spinal cord dorsal/ventral patterning

PMID:16459298[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3619046

P

has_participant:(EMAPA:16530)

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX1

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:10564661[10]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX1

F

Seeded From UniProt

complete

enables

GO:0008013

beta-catenin binding

PMID:11477086[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007368

determination of left/right symmetry

PMID:16155214[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3512046

P

has_participant:(EMAPA:16075)

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:19684112[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:19684112[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10564661[10]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX1

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX1

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX1

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003281

ventricular septum development

PMID:25807483[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001947

heart looping

PMID:16155214[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3512046

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001843

neural tube closure

PMID:16155214[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3512046

P

has_participant:(EMAPA:16530)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:16459298[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:10564661[10]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX1

P

Seeded From UniProt

complete

involved_in

GO:0045879

negative regulation of smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX1
ensembl:ENSP00000358918

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX1
ensembl:ENSP00000358918

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX1
ensembl:ENSP00000358918

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX1
ensembl:ENSP00000358918

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX1
ensembl:ENSP00000358918

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX1
ensembl:ENSP00000358918

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016591

F

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:16254602[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16316410[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16254602[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045879

negative regulation of smoothened signaling pathway

PMID:10531011[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10531011[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:10531011[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-NUL-5610751
Reactome:R-NUL-5610740
Reactome:R-NUL-5610715
Reactome:R-NUL-5610714
Reactome:R-NUL-5610711
Reactome:R-MMU-5610710

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
  2. Raducu, M et al. (2016) SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. EMBO J. 35 1400-16 PubMed GONUTS page
  3. Humke, EW et al. (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 24 670-82 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page
  6. 6.0 6.1 6.2 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page
  7. Ocbina, PJ & Anderson, KV (2008) Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts. Dev. Dyn. 237 2030-8 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Svärd, J et al. (2006) Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 10 187-97 PubMed GONUTS page
  9. 9.0 9.1 Barnfield, PC et al. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73 397-405 PubMed GONUTS page
  10. 10.0 10.1 10.2 Stone, DM et al. (1999) Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J. Cell. Sci. 112 ( Pt 23) 4437-48 PubMed GONUTS page
  11. Meng, X et al. (2001) Suppressor of fused negatively regulates beta-catenin signaling. J. Biol. Chem. 276 40113-9 PubMed GONUTS page
  12. 12.0 12.1 12.2 Cooper, AF et al. (2005) Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 132 4407-17 PubMed GONUTS page
  13. 13.0 13.1 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page
  14. 14.0 14.1 14.2 Ding, Q et al. (1999) Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr. Biol. 9 1119-22 PubMed GONUTS page