MOUSE:STXB1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Stxbp1
Protein Name(s)	Syntaxin-binding protein 1 Protein unc-18 homolog 1 Unc18-1 Protein unc-18 homolog A Unc-18A
External Links
UniProt	O08599
EMBL	D45903 AB012697 AF326545 AF326563 AL845471 AL845471 AL845471 BC031728
CCDS	CCDS15933.1 CCDS50572.1
RefSeq	NP_001107041.1 NP_033321.2
UniGene	Mm.278865
ProteinModelPortal	O08599
SMR	O08599
BioGrid	203564
DIP	DIP-31951N
IntAct	O08599
MINT	MINT-4136044
STRING	10090.ENSMUSP00000089051
PhosphoSite	O08599
MaxQB	O08599
PaxDb	O08599
PRIDE	O08599
Ensembl	ENSMUST00000050000 ENSMUST00000077458
GeneID	20910
KEGG	mmu:20910
UCSC	uc008jha.2 uc008jhb.2
CTD	6812
MGI	MGI:107363
eggNOG	COG5158
GeneTree	ENSGT00390000005206
HOGENOM	HOG000232146
HOVERGEN	HBG052710
InParanoid	O08599
KO	K15292
OMA	QVPRKER
OrthoDB	EOG78PV8M
PhylomeDB	O08599
TreeFam	TF313242
Reactome	REACT_205038 REACT_229514 REACT_242222 REACT_245631 REACT_263148
ChiTaRS	Stxbp1
NextBio	299797
PRO	PR:O08599
Proteomes	UP000000589
Bgee	O08599
CleanEx	MM_STXBP1
ExpressionAtlas	O08599
Genevestigator	O08599
GO	GO:0070062 GO:0005739 GO:0005886 GO:0031091 GO:0043234 GO:0044822 GO:0017075 GO:0007412 GO:0006887 GO:0060292 GO:0043524 GO:0032229 GO:0007274 GO:0007269 GO:0070527 GO:0002576 GO:0045956 GO:0050821 GO:0015031 GO:0010807 GO:0031629 GO:0016188 GO:0006904
Gene3D	3.40.50.1910
InterPro	IPR027482 IPR001619
PANTHER	PTHR11679
Pfam	PF00995
PIRSF	PIRSF005715
SUPFAM	SSF56815

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006904	vesicle docking involved in exocytosis	PMID:18703708^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000166)	Seeded From UniProt	complete
involved_in	GO:0099525	presynaptic dense core vesicle exocytosis	PMID:11545717^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000336)	Seeded From UniProt	complete
part_of	GO:0048787	presynaptic active zone membrane	PMID:23821748^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:23821748^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0098891	extrinsic component of presynaptic active zone membrane	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0017075 GO:0048787	C	part_of:(CL:0002609) part_of:(GO:0030424)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23821748^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002609) part_of:(GO:0030424)	Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	PMID:18703708^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17110441^[5]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17110441^[5]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17110441^[5]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0016082	synaptic vesicle priming	PMID:17110441^[5]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0016082	synaptic vesicle priming	PMID:17110441^[5]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0016082	synaptic vesicle priming	PMID:17110441^[5]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903296	positive regulation of glutamate secretion, neurotransmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0106022	positive regulation of vesicle docking	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072659	protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071346	cellular response to interferon-gamma	PMID:19144319^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070527	platelet aggregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060292	long-term synaptic depression	PMID:17110441^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183278	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61765	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045956	positive regulation of calcium ion-dependent exocytosis	PMID:15123626^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045921	positive regulation of exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	PMID:19144319^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:15255974^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183278	P	occurs_in:(EMAPA:19039) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043306	positive regulation of mast cell degranulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032229	negative regulation of synaptic transmission, GABAergic	PMID:17167098^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_participant:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031338	regulation of vesicle fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031333	negative regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	P		Seeded From UniProt	complete
part_of	GO:0031091	platelet alpha granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	F		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	F		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	PMID:7890599^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35526	F		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	PMID:7553862^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61765	F		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	F		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016188	synaptic vesicle maturation	PMID:15145078^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183278	P	occurs_in:(EMAPA:19045) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010807	regulation of synaptic vesicle priming	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007412	axon target recognition	PMID:15182301^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183278	P	occurs_in:(EMAPA:16898) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007274	neuromuscular synaptic transmission	PMID:17110441^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183278	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007269	neurotransmitter secretion	PMID:15255974^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183278	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006904	vesicle docking involved in exocytosis	PMID:11545717^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183278	P	occurs_in:(EMAPA:18426) occurs_in:(CL:0000336)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006887	exocytosis	PMID:11545717^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183278	P	occurs_in:(EMAPA:18426) occurs_in:(CL:0000336)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003006	developmental process involved in reproduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002576	platelet degranulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61764	P		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3785	F		Seeded From UniProt	complete
involved_in	GO:2000367	regulation of acrosomal vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	P		Seeded From UniProt	complete
involved_in	GO:0070527	platelet aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	P		Seeded From UniProt	complete
involved_in	GO:0035493	SNARE complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	P		Seeded From UniProt	complete
part_of	GO:0031091	platelet alpha granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	F		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61764 ensembl:ENSP00000362399	P		Seeded From UniProt	complete
involved_in	GO:1903296	positive regulation of glutamate secretion, neurotransmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
involved_in	GO:0106022	positive regulation of vesicle docking	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	F		Seeded From UniProt	complete
involved_in	GO:0045921	positive regulation of exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
involved_in	GO:0043306	positive regulation of mast cell degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
involved_in	GO:0031338	regulation of vesicle fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
involved_in	GO:0031333	negative regulation of protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	F		Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	F		Seeded From UniProt	complete
involved_in	GO:0010807	regulation of synaptic vesicle priming	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	C		Seeded From UniProt	complete
involved_in	GO:0003006	developmental process involved in reproduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	P		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61765 ensembl:ENSRNOP00000021189	F		Seeded From UniProt	complete
involved_in	GO:0006904	vesicle docking involved in exocytosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001619 InterPro:IPR036045	P		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001619 InterPro:IPR036045	P		Seeded From UniProt	complete
involved_in	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	PMID:16782817^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-216883	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

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↑ ^1.0 ^1.1 Gerber, SH et al. (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321 1507-10 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Voets, T et al. (2001) Munc18-1 promotes large dense-core vesicle docking. Neuron 31 581-91 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Pertsinidis, A et al. (2013) Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ. Proc. Natl. Acad. Sci. U.S.A. 110 E2812-20 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Toonen, RF et al. (2006) Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size. Proc. Natl. Acad. Sci. U.S.A. 103 18332-7 PubMed GONUTS page
↑ ^6.0 ^6.1 Trost, M et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30 143-54 PubMed GONUTS page
↑ Lilja, L et al. (2004) Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. J. Biol. Chem. 279 29534-41 PubMed GONUTS page
↑ ^8.0 ^8.1 Heeroma, JH et al. (2004) Trophic support delays but does not prevent cell-intrinsic degeneration of neurons deficient for munc18-1. Eur. J. Neurosci. 20 623-34 PubMed GONUTS page
↑ Ho, A et al. (2006) Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J. Neurosci. 26 13089-101 PubMed GONUTS page
↑ Katagiri, H et al. (1995) A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J. Biol. Chem. 270 4963-6 PubMed GONUTS page
↑ McMahon, HT et al. (1995) Complexins: cytosolic proteins that regulate SNAP receptor function. Cell 83 111-9 PubMed GONUTS page
↑ Bouwman, J et al. (2004) Quantification of synapse formation and maintenance in vivo in the absence of synaptic release. Neuroscience 126 115-26 PubMed GONUTS page
↑ Korteweg, N et al. (2004) Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion. Eur. J. Neurosci. 19 2944-52 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Sakane, A et al. (2006) Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3. Proc. Natl. Acad. Sci. U.S.A. 103 10029-34 PubMed GONUTS page

[PMID:18703708-1] 1.0 ^1.1 Gerber, SH et al. (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321 1507-10 PubMed GONUTS page

[PMID:11545717-2] 2.0 ^2.1 ^2.2 Voets, T et al. (2001) Munc18-1 promotes large dense-core vesicle docking. Neuron 31 581-91 PubMed GONUTS page

[PMID:23821748-3] 3.0 ^3.1 ^3.2 Pertsinidis, A et al. (2013) Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ. Proc. Natl. Acad. Sci. U.S.A. 110 E2812-20 PubMed GONUTS page

[PMID:17634366-4] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:17110441-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Toonen, RF et al. (2006) Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size. Proc. Natl. Acad. Sci. U.S.A. 103 18332-7 PubMed GONUTS page

[PMID:19144319-6] 6.0 ^6.1 Trost, M et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30 143-54 PubMed GONUTS page

[PMID:15123626-7] Lilja, L et al. (2004) Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. J. Biol. Chem. 279 29534-41 PubMed GONUTS page

[PMID:15255974-8] 8.0 ^8.1 Heeroma, JH et al. (2004) Trophic support delays but does not prevent cell-intrinsic degeneration of neurons deficient for munc18-1. Eur. J. Neurosci. 20 623-34 PubMed GONUTS page

[PMID:17167098-9] Ho, A et al. (2006) Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J. Neurosci. 26 13089-101 PubMed GONUTS page

[PMID:7890599-10] Katagiri, H et al. (1995) A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J. Biol. Chem. 270 4963-6 PubMed GONUTS page

[PMID:7553862-11] McMahon, HT et al. (1995) Complexins: cytosolic proteins that regulate SNAP receptor function. Cell 83 111-9 PubMed GONUTS page

[PMID:15145078-12] Bouwman, J et al. (2004) Quantification of synapse formation and maintenance in vivo in the absence of synaptic release. Neuroscience 126 115-26 PubMed GONUTS page

[PMID:15182301-13] Korteweg, N et al. (2004) Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion. Eur. J. Neurosci. 19 2944-52 PubMed GONUTS page

[PMID:14651853-14] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:16782817-15] Sakane, A et al. (2006) Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3. Proc. Natl. Acad. Sci. U.S.A. 103 10029-34 PubMed GONUTS page

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