MOUSE:SPIR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein spire homolog 1
External Links
UniProt	Q52KF3
EMBL	BC046486 BC058669 BC094375
UniGene	Mm.208723
ProteinModelPortal	Q52KF3
SMR	Q52KF3
iPTMnet	Q52KF3
PhosphoSite	Q52KF3
MaxQB	Q52KF3
PRIDE	Q52KF3
Ensembl	ENSMUST00000082243
UCSC	uc008fmn.1 uc012bej.1
MGI	MGI:1915416
GeneTree	ENSGT00390000003058
HOGENOM	HOG000013039
HOVERGEN	HBG058898
InParanoid	Q52KF3
PhylomeDB	Q52KF3
ChiTaRS	Spire1
PRO	PR:Q52KF3
Proteomes	UP000000589
Bgee	Q52KF3
CleanEx	MM_SPIRE1
ExpressionAtlas	Q52KF3
Genevisible	Q52KF3
GO	GO:0005938 GO:0032154 GO:0030659 GO:0005856 GO:0005829 GO:0005794 GO:0048471 GO:0005886 GO:0030036 GO:0045010 GO:0036089 GO:0051295 GO:0070649 GO:0048193 GO:0046907 GO:0040038 GO:0015031 GO:0016192
InterPro	IPR011019 IPR029901 IPR029905 IPR011011
PANTHER	PTHR21345 PTHR21345:SF2
Pfam	PF16474
SUPFAM	SSF57903
PROSITE	PS51377

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0070649	formin-nucleated actin cable assembly	PMID:21620703^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051295	establishment of meiotic spindle localization	PMID:21620703^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046907	intracellular transport	PMID:21983562^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040038	polar body extrusion after meiotic divisions	PMID:21620703^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036089	cleavage furrow formation	PMID:21620703^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0032154	cleavage furrow	PMID:21620703^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:21983562^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:21620703^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:21983562^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21983562^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000781	positive regulation of double-strand break repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08AE8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070649	formin-nucleated actin cable assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08AE8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060996	dendritic spine development	PMID:24345451^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4310183	P	occurs_in:(EMAPA:35313)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051295	establishment of meiotic spindle localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08AE8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048193	Golgi vesicle transport	PMID:11747823^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08AE8	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08AE8	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11747823^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q08AE8	C		Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001662	behavioral fear response	PMID:24345451^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4310183	P		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029901 InterPro:IPR029905	F		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029901 InterPro:IPR029905	P		Seeded From UniProt	complete
involved_in	GO:0045010	actin nucleation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029901 InterPro:IPR029905	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0467	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Pfender, S et al. (2011) Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Curr. Biol. 21 955-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Schuh, M (2011) An actin-dependent mechanism for long-range vesicle transport. Nat. Cell Biol. 13 1431-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Pleiser, S et al. () Enhanced fear expression in Spir-1 actin organizer mutant mice. Eur. J. Cell Biol. 93 225-37 PubMed GONUTS page
↑ ^4.0 ^4.1 Kerkhoff, E et al. (2001) The Spir actin organizers are involved in vesicle transport processes. Curr. Biol. 11 1963-8 PubMed GONUTS page

[PMID:21620703-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Pfender, S et al. (2011) Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Curr. Biol. 21 955-60 PubMed GONUTS page

[PMID:21983562-2] 2.0 ^2.1 ^2.2 ^2.3 Schuh, M (2011) An actin-dependent mechanism for long-range vesicle transport. Nat. Cell Biol. 13 1431-6 PubMed GONUTS page

[PMID:24345451-3] 3.0 ^3.1 Pleiser, S et al. () Enhanced fear expression in Spir-1 actin organizer mutant mice. Eur. J. Cell Biol. 93 225-37 PubMed GONUTS page

[PMID:11747823-4] 4.0 ^4.1 Kerkhoff, E et al. (2001) The Spir actin organizers are involved in vesicle transport processes. Curr. Biol. 11 1963-8 PubMed GONUTS page

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MOUSE:SPIR1

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