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MOUSE:SMTL1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Smtnl1
Protein Name(s) Smoothelin-like protein 1

Calponin homology-associated smooth muscle protein CHASM

External Links
UniProt Q99LM3
EMBL AL928914
BC002317
CCDS CCDS16195.1
RefSeq NP_077192.1
XP_006500172.1
UniGene Mm.33452
PDB 2JV9
2K3S
PDBsum 2JV9
2K3S
DisProt DP00742
ProteinModelPortal Q99LM3
SMR Q99LM3
IntAct Q99LM3
MINT MINT-7966054
STRING 10090.ENSMUSP00000028471
PhosphoSite Q99LM3
PaxDb Q99LM3
PRIDE Q99LM3
Ensembl ENSMUST00000028471
GeneID 68678
KEGG mmu:68678
UCSC uc008kjg.1
CTD 219537
MGI MGI:1915928
eggNOG COG5069
GeneTree ENSGT00760000118856
HOGENOM HOG000154352
HOVERGEN HBG095368
InParanoid Q99LM3
OMA LQGEANG
OrthoDB EOG7C2R13
PhylomeDB Q99LM3
TreeFam TF316716
EvolutionaryTrace Q99LM3
NextBio 327680
PRO PR:Q99LM3
Proteomes UP000000589
Bgee Q99LM3
CleanEx MM_SMTNL1
Genevestigator Q99LM3
GO GO:0043292
GO:0005737
GO:0031674
GO:0031430
GO:0005634
GO:0017020
GO:0008157
GO:0004864
GO:0048644
GO:0043086
GO:0045908
GO:0018105
GO:0045907
GO:0050790
GO:0014823
GO:0042493
Gene3D 1.10.418.10
InterPro IPR001715
Pfam PF00307
SMART SM00033
SUPFAM SSF47576
PROSITE PS50021

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016481

negative regulation of transcription

PMID:21771785[1]

ECO:0000314

P

Proven in Figure 7B

complete
CACAO 2113

enables

GO:0005516

calmodulin binding

PMID:18477568[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P62149

F

Seeded From UniProt

complete

enables

GO:0005523

tropomyosin binding

PMID:22424482[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04268,UniProtKB:P19352

F

Seeded From UniProt

complete

enables

GO:0097718

disordered domain specific binding

PMID:22424482[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99LM3

F

Seeded From UniProt

complete

enables

GO:0051401

CH domain binding

PMID:22424482[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99LM3

F

Seeded From UniProt

complete

enables

GO:0043621

protein self-association

PMID:22424482[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:21771785[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097756

negative regulation of blood vessel diameter

PMID:20634291[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045907

positive regulation of vasoconstriction

PMID:20634291[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043292

contractile fiber

PMID:20634291[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008157

protein phosphatase 1 binding

PMID:20634291[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9DBR7

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20634291[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20634291[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045907

positive regulation of vasoconstriction

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915928
PANTHER:PTN001566592

P

Seeded From UniProt

complete

part_of

GO:0043292

contractile fiber

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915928
PANTHER:PTN001566592
UniProtKB:A8MU46

C

Seeded From UniProt

complete

part_of

GO:0031941

filamentous actin

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921642
PANTHER:PTN001141409

C

Seeded From UniProt

complete

part_of

GO:0031674

I band

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915928
PANTHER:PTN001566592

C

Seeded From UniProt

complete

part_of

GO:0031430

M band

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915928
PANTHER:PTN001566592

C

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921642
PANTHER:PTN001141409

P

Seeded From UniProt

complete

enables

GO:0008157

protein phosphatase 1 binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915928
PANTHER:PTN001566592

F

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921642
PANTHER:PTN001141409

C

Seeded From UniProt

complete

enables

GO:0005523

tropomyosin binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915928
PANTHER:PTN001566592

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097756

negative regulation of blood vessel diameter

PMID:18310078[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3796616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048644

muscle organ morphogenesis

PMID:18310078[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3796616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045907

positive regulation of vasoconstriction

PMID:18310078[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3796616

P

Seeded From UniProt

complete

part_of

GO:0043292

contractile fiber

PMID:18310078[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:32717)|part_of:(EMAPA:36390)

Seeded From UniProt

complete

part_of

GO:0043292

contractile fiber

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:A8MU46

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:18310078[6]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:35578)

Seeded From UniProt

complete

part_of

GO:0031674

I band

PMID:18310078[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:36390)

Seeded From UniProt

complete

part_of

GO:0031430

M band

PMID:18310078[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:36390)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0018105

peptidyl-serine phosphorylation

PMID:18310078[6]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:35578)

Seeded From UniProt

complete

enables

GO:0017020

myosin phosphatase regulator activity

PMID:18310078[6]

ECO:0000266

sequence orthology evidence used in manual assertion

RefSeq:XP_001069604

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014823

response to activity

PMID:18310078[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3796616

P

Seeded From UniProt

complete

enables

GO:0004864

protein phosphatase inhibitor activity

PMID:18310078[6]

ECO:0000266

sequence orthology evidence used in manual assertion

RefSeq:XP_001069604

F

Seeded From UniProt

complete

involved_in

GO:0032515

negative regulation of phosphoprotein phosphatase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004864

P

Seeded From UniProt

complete

involved_in

GO:0043666

regulation of phosphoprotein phosphatase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0017020

P

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0112

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0031430

M band

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0315

C

Seeded From UniProt

complete

part_of

GO:0031674

I band

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0478

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Bodoor, K et al. (2011) Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. J. Biol. Chem. 286 31839-51 PubMed GONUTS page
  2. ↑ Ishida, H et al. (2008) Solution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxation. J. Biol. Chem. 283 20569-78 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 MacDonald, JA et al. (2012) Intrinsically disordered N-terminus of calponin homology-associated smooth muscle protein (CHASM) interacts with the calponin homology domain to enable tropomyosin binding. Biochemistry 51 2694-705 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Lontay, B et al. (2010) Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. J. Biol. Chem. 285 29357-66 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Wooldridge, AA et al. (2008) Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J. Biol. Chem. 283 11850-9 PubMed GONUTS page
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