MOUSE:SIK3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sik3 (synonyms: Kiaa0999, Qsk)
Protein Name(s)	Serine/threonine-protein kinase SIK3 Salt-inducible kinase 3 SIK-3 Serine/threonine-protein kinase QSK
External Links
UniProt	Q6P4S6
EMBL	AK017789 BC033915 BC063268 BC080688 BC082313 AK129257
RefSeq	NP_081774.3
UniGene	Mm.219459
ProteinModelPortal	Q6P4S6
SMR	Q6P4S6
BioGrid	214193
IntAct	Q6P4S6
PhosphoSite	Q6P4S6
MaxQB	Q6P4S6
PaxDb	Q6P4S6
PRIDE	Q6P4S6
GeneID	70661
KEGG	mmu:70661
UCSC	uc009pha.1
CTD	23387
MGI	MGI:2446296
eggNOG	COG0515
HOGENOM	HOG000154056
HOVERGEN	HBG079682
InParanoid	Q6P4S6
KO	K16311
PhylomeDB	Q6P4S6
ChiTaRS	Sik3
NextBio	332051
PRO	PR:Q6P4S6
Proteomes	UP000000589
CleanEx	MM_BC033915
Genevestigator	Q6P4S6
GO	GO:0005737 GO:0005524 GO:0000287 GO:0004674 GO:0060351 GO:0001958 GO:0035108 GO:0035264 GO:0006468 GO:0032880 GO:0048705
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 IPR015940
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108 PS50030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0045840	positive regulation of mitosis	PMID:24743732^[1]	ECO:0000315			P		Figure 2 and figure 3	complete
involved_in	GO:1904515	positive regulation of TORC2 signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y2K2	P		Seeded From UniProt	complete
involved_in	GO:1904263	positive regulation of TORC1 signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y2K2	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y2K2	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y2K2	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y2K2	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y2K2	F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN000680111 RGD:619882 RGD:708483 UniProtKB:Q96L34	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002519176 RGD:619882 UniProtKB:Q7KZI7 UniProtKB:Q9P0L2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038167 MGI:MGI:2446296 PANTHER:PTN002519176 RGD:619882 SGD:S000000015 UniProtKB:P27448 UniProtKB:Q7KZI7 UniProtKB:Q96L34 UniProtKB:Q96RG2 UniProtKB:Q9P0L2 WB:WBGene00003916	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN002519176 RGD:619882 RGD:708483 SGD:S000000015 SGD:S000005405 UniProtKB:A0A1D8PN61 UniProtKB:P27448 UniProtKB:Q7KZI7 UniProtKB:Q93V58 UniProtKB:Q96L34 UniProtKB:Q96RG2 UniProtKB:Q9P0L2 UniProtKB:Q9Y2K2 WB:WBGene00003916	F		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260934 PANTHER:PTN000680111 RGD:619882 UniProtKB:Q96L34	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060351	cartilage development involved in endochondral bone morphogenesis	PMID:22318228^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5317918	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048705	skeletal system morphogenesis	PMID:22318228^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5317918	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:22318228^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5317918	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035108	limb morphogenesis	PMID:22318228^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5317918	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032880	regulation of protein localization	PMID:22318228^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5317918	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y2K2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22318228^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000138)	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y2K2	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y2K2	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y2K2	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001958	endochondral ossification	PMID:22318228^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5317918	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y2K2	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034672	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR034672	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chen, H et al. (2014) Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death. Cell Death Dis 5 e1177 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Sasagawa, S et al. (2012) SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development 139 1153-63 PubMed GONUTS page

[PMID:24743732-1] Chen, H et al. (2014) Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death. Cell Death Dis 5 e1177 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22318228-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Sasagawa, S et al. (2012) SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development 139 1153-63 PubMed GONUTS page

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MOUSE:SIK3

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