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MOUSE:SHB
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Shb | |
| Protein Name(s) | SH2 domain-containing adapter protein B | |
| External Links | ||
| UniProt | Q6PD21 | |
| EMBL | AK145414 AL772376 BC058986 | |
| CCDS | CCDS51173.1 | |
| RefSeq | NP_001028478.1 | |
| UniGene | Mm.251716 | |
| ProteinModelPortal | Q6PD21 | |
| SMR | Q6PD21 | |
| BioGrid | 230937 | |
| IntAct | Q6PD21 | |
| MINT | MINT-8013521 | |
| STRING | 10090.ENSMUSP00000060433 | |
| PhosphoSite | Q6PD21 | |
| MaxQB | Q6PD21 | |
| PaxDb | Q6PD21 | |
| PRIDE | Q6PD21 | |
| Ensembl | ENSMUST00000061986 | |
| GeneID | 230126 | |
| KEGG | mmu:230126 | |
| UCSC | uc008sst.2 uc008ssu.1 | |
| CTD | 6461 | |
| MGI | MGI:98294 | |
| eggNOG | NOG80632 | |
| GeneTree | ENSGT00390000015203 | |
| HOGENOM | HOG000038038 | |
| HOVERGEN | HBG066172 | |
| InParanoid | Q6PD21 | |
| OMA | RPDYREQ | |
| OrthoDB | EOG793B9C | |
| PhylomeDB | Q6PD21 | |
| TreeFam | TF325799 | |
| Reactome | REACT_243939 REACT_257088 | |
| ChiTaRS | Shb | |
| NextBio | 379808 | |
| PRO | PR:Q6PD21 | |
| Proteomes | UP000000589 | |
| Bgee | Q6PD21 | |
| ExpressionAtlas | Q6PD21 | |
| Genevestigator | Q6PD21 | |
| GO | GO:0005737 GO:0005886 GO:0001948 GO:0005070 GO:0001525 GO:0006915 GO:0042100 GO:0001568 GO:0048514 GO:0030154 GO:0071425 GO:0030097 GO:1900194 GO:0006469 GO:0045931 GO:0009967 | |
| Gene3D | 3.30.505.10 | |
| InterPro | IPR000980 | |
| Pfam | PF00017 | |
| PRINTS | PR00401 | |
| SMART | SM00252 | |
| SUPFAM | SSF55550 | |
| PROSITE | PS50001 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0001784 |
phosphotyrosine residue binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001031645 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1900194 |
negative regulation of oocyte maturation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3721903 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071425 |
hematopoietic stem cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3721903 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3721903 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048514 |
blood vessel morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:103178 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048514 |
blood vessel morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045931 |
positive regulation of mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3721903 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045624 |
positive regulation of T-helper cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3721903 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042100 |
B cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030097 |
hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3721903 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3721903 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001784 |
phosphotyrosine residue binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001568 |
blood vessel development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3721903 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009967 |
positive regulation of signal transduction |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005070 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009967 |
positive regulation of signal transduction |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005070 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005070 |
SH3/SH2 adaptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005070 |
SH3/SH2 adaptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Calounova, G et al. (2010) The Src homology 2 domain-containing adapter protein B (SHB) regulates mouse oocyte maturation. PLoS ONE 5 e11155 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gustafsson, K et al. (2013) The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp. Cell Res. 319 1852-64 PubMed GONUTS page
- ↑ 4.0 4.1 Gustafsson, K et al. (2014) Absence of the adaptor protein Shb potentiates the T helper type 2 response in a mouse model of atopic dermatitis. Immunology 143 33-41 PubMed GONUTS page
- ↑ 5.0 5.1 Rolny, C et al. (2005) Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. Exp. Cell Res. 308 381-93 PubMed GONUTS page
- ↑ 6.0 6.1 Annerén, C (2002) Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin. J. Endocrinol. 172 145-53 PubMed GONUTS page
- ↑ Kriz, V et al. (2006) The SHB adapter protein is required for normal maturation of mesoderm during in vitro differentiation of embryonic stem cells. J. Biol. Chem. 281 34484-91 PubMed GONUTS page
- ↑ Funa, NS et al. (2009) Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth. Cancer Res. 69 2141-8 PubMed GONUTS page
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