MOUSE:SHAN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Shank1
Protein Name(s)	SH3 and multiple ankyrin repeat domains protein 1 Shank1
External Links
UniProt	D3YZU1
EMBL	AC152939 CO436178
CCDS	CCDS52229.1
RefSeq	NP_001029287.1 XP_006540927.1
UniGene	Mm.360368
ProteinModelPortal	D3YZU1
SMR	D3YZU1
BioGrid	232591
IntAct	D3YZU1
MaxQB	D3YZU1
PRIDE	D3YZU1
Ensembl	ENSMUST00000107938
GeneID	243961
KEGG	mmu:243961
UCSC	uc012fjo.1
CTD	50944
MGI	MGI:3613677
GeneTree	ENSGT00510000046474
HOGENOM	HOG000293276
InParanoid	D3YZU1
KO	K15009
OMA	WEEGPGP
OrthoDB	EOG7X6KZ7
TreeFam	TF324593
NextBio	386058
PRO	PR:D3YZU1
Proteomes	UP000000589
Bgee	D3YZU1
ExpressionAtlas	D3YZU1
GO	GO:0030054 GO:0005737 GO:0030425 GO:0043197 GO:0060076 GO:0017146 GO:0043005 GO:0097481 GO:0005886 GO:0045211 GO:0071532 GO:0030160 GO:0042802 GO:0035255 GO:0008022 GO:0032403 GO:0097110 GO:0017124 GO:0031877 GO:0030534 GO:0008306 GO:0060997 GO:0050894 GO:0046959 GO:0007616 GO:0032232 GO:0050885 GO:0042048 GO:0060999 GO:2000463 GO:0006461 GO:0035418 GO:2000311 GO:0060013 GO:0035176 GO:0060074 GO:0071625
Gene3D	1.10.150.50 1.25.40.20 2.30.42.10
InterPro	IPR002110 IPR020683 IPR001478 IPR001660 IPR013761 IPR021129 IPR011511 IPR001452
Pfam	PF12796 PF00595 PF00536 PF07653
SMART	SM00248 SM00228 SM00454 SM00326
SUPFAM	SSF47769 SSF48403 SSF50044 SSF50156
PROSITE	PS50297 PS50088 PS50106 PS50105 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060013	righting reflex	PMID:21695253^[1]	ECO:0000315			P		Table 2 in somatosensory reflex surface righting was slower to flip over onto abdomen with four paws touching the surface in Shank1 knockout mice compared to heterozygous or wild type mice.	complete CACAO 3101
	GO:0071625	vocalization behavior	PMID:21695253^[1]	ECO:0000315			P		Figure 2A shows knockout Shank1 mice showed fewer ultrasonic vocalization and shorter total calling time (figure 2B) compared to heterozygous or wild type mice. Higher peak frequency (figure 3A) of calls in Shank1 knockout mice compared to heterozygous or wild type mice.	complete CACAO 3102
	GO:0046959	habituation	PMID:21695253^[1]	ECO:0000315			P		Adult male mice exposed to open field without female urine and then exposed after female urine. Wild type males showed reduction in rearing and distance traveled after being exposed to female urine, figure 8A, B. However this reduction in rearing and distance travelled was not seen in knock out Shank1 males mice figure 8C and 8D.	complete CACAO 3103
	GO:0042048	olfactory behavior	PMID:21695253^[1]	ECO:0000315			P		Adult male mice exposed to open field without female urine and then exposed after female experience. Wild type males showed reduction in rearing and distance traveled after being exposed to female urine, figure 8A, B. However this reduction in rearing and distance travelled was not seen in knock out Shank1 male mice figure 8C and 8D. Therefore knockout mice showed impaired olfactory behavior. Figure 9B time spent in female urine spot was reduced in knockout Shank1 mice compared to heterozygous or wild type mice.	complete CACAO 3104
	GO:0005886	plasma membrane	PMID:15207857^[2]	ECO:0000314			C		COS7 cells expressed with Glur1, Shank1 localized to membrane figure 1B.	complete
	GO:0005634	nucleus	PMID:15207857^[2]	ECO:0000314			C		Figure 1A, Shank1 distributed in the nucleus of COS7 cells.	complete
	GO:0043197	dendritic spine	PMID:15207857^[2]	ECO:0000314			C		Figure 3B and C, immunohistochemical analysis showed Shank1 protein staining on dendritic spines of Purkinje cells.	complete
enables	GO:0098919	structural constituent of postsynaptic density	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0014069,GO:0030160	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21144999^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0005377)	Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046959	habituation	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060013	righting reflex	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:18272690^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:18272690^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:18272690^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	F		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071532	ankyrin repeat binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	F		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:18272690^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:18272690^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	P		Seeded From UniProt	complete
involved_in	GO:0060013	righting reflex	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	PMID:20868654^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046959	habituation	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0045211	postsynaptic membrane	PMID:15207857^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:15207857^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21795692^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	F		Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	PMID:18272690^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:15207857^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61625	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:16606358^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23818	F		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:21695253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	F		Seeded From UniProt	complete
enables	GO:0031877	somatostatin receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21940441^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	PMID:18272690^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	C		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	F		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	PMID:15207857^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	PMID:18272690^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	F		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:18272690^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV48	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15207857^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0000279	western blot evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:18272690^[4]	ECO:0000279	western blot evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18272690^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18272690^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18272690^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18272690^[4]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:18272690^[4]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:18272690^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:18272690^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:18272690^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:18272690^[4]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:18272690^[4]	ECO:0000279	western blot evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:18272690^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:18272690^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0097107	postsynaptic density assembly	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880 RGD:621011	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:3613677 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0051124	synaptic growth at neuromuscular junction	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040752 PANTHER:PTN001191880	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880 ZFIN:ZDB-GENE-060503-369	P		Seeded From UniProt	complete
colocalizes_with	GO:0045211	postsynaptic membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:621011	C		Seeded From UniProt	complete
part_of	GO:0044309	neuron spine	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 PANTHER:PTN001191880	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:621011	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191880	C		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191878 RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191880	C		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3613677 PANTHER:PTN001191878 RGD:621011 RGD:69264	F		Seeded From UniProt	complete
enables	GO:0030159	receptor signaling complex adaptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001191878 RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040752 MGI:MGI:3613677 PANTHER:PTN001191880 RGD:628772 RGD:69264	C		Seeded From UniProt	complete
colocalizes_with	GO:0008328	ionotropic glutamate receptor complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2671987 MGI:MGI:3613677 PANTHER:PTN001191878	C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930016 MGI:MGI:2671987 PANTHER:PTN001191880	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071625	vocalization behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y566	P		Seeded From UniProt	complete
enables	GO:0071532	ankyrin repeat binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0065003	protein-containing complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060074	synapse maturation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050894	determination of affect	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y566	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:15950311^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y566	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032232	negative regulation of actin filament bundle assembly	PMID:19208628^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031877	somatostatin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030534	adult behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y566	P		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
enables	GO:0030159	receptor signaling complex adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
colocalizes_with	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	C		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y566	C		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621011	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y566	C		Seeded From UniProt	complete
involved_in	GO:0099562	maintenance of postsynaptic density structure	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098919	P		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y566 ensembl:ENSP00000293441	P		Seeded From UniProt	complete
involved_in	GO:0050894	determination of affect	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y566 ensembl:ENSP00000293441	P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y566 ensembl:ENSP00000293441	P		Seeded From UniProt	complete
involved_in	GO:0030534	adult behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y566 ensembl:ENSP00000293441	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y566 ensembl:ENSP00000293441	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y566 ensembl:ENSP00000293441	C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
enables	GO:0071532	ankyrin repeat binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	P		Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
enables	GO:0031877	somatostatin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
enables	GO:0030160	GKAP/Homer scaffold activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
enables	GO:0030159	receptor signaling complex adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	C		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV48 ensembl:ENSRNOP00000026100	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Wöhr, M et al. (2011) Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior. PLoS ONE 6 e20631 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Uemura, T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell. Neurosci. 26 330-41 PubMed GONUTS page
↑ Dani, A et al. (2010) Superresolution imaging of chemical synapses in the brain. Neuron 68 843-56 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 ^4.25 ^4.26 ^4.27 ^4.28 ^4.29 ^4.30 Hung, AY et al. (2008) Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J. Neurosci. 28 1697-708 PubMed GONUTS page
↑ Silverman, JL et al. (2011) Sociability and motor functions in Shank1 mutant mice. Brain Res. 1380 120-37 PubMed GONUTS page
↑ Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
↑ Uchino, S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J. Neurochem. 97 1203-14 PubMed GONUTS page
↑ Yoshida, T et al. (2011) IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. J. Neurosci. 31 13485-99 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 ^9.14 ^9.15 ^9.16 ^9.17 ^9.18 ^9.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Francke, F et al. (2005) Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain. Brain Res. Mol. Brain Res. 139 31-41 PubMed GONUTS page
↑ Sawallisch, C et al. (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J. Biol. Chem. 284 9225-36 PubMed GONUTS page

[PMID:21695253-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Wöhr, M et al. (2011) Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior. PLoS ONE 6 e20631 PubMed GONUTS page

[PMID:15207857-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Uemura, T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell. Neurosci. 26 330-41 PubMed GONUTS page

[PMID:21144999-3] Dani, A et al. (2010) Superresolution imaging of chemical synapses in the brain. Neuron 68 843-56 PubMed GONUTS page

[PMID:18272690-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 ^4.25 ^4.26 ^4.27 ^4.28 ^4.29 ^4.30 Hung, AY et al. (2008) Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J. Neurosci. 28 1697-708 PubMed GONUTS page

[PMID:20868654-5] Silverman, JL et al. (2011) Sociability and motor functions in Shank1 mutant mice. Brain Res. 1380 120-37 PubMed GONUTS page

[PMID:21795692-6] Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page

[PMID:16606358-7] Uchino, S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J. Neurochem. 97 1203-14 PubMed GONUTS page

[PMID:21940441-8] Yoshida, T et al. (2011) IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. J. Neurosci. 31 13485-99 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 ^9.14 ^9.15 ^9.16 ^9.17 ^9.18 ^9.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15950311-10] Francke, F et al. (2005) Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain. Brain Res. Mol. Brain Res. 139 31-41 PubMed GONUTS page

[PMID:19208628-11] Sawallisch, C et al. (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J. Biol. Chem. 284 9225-36 PubMed GONUTS page

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MOUSE:SHAN1

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