MOUSE:SC6A4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Slc6a4 (synonyms: Htt, Sert)
Protein Name(s)	Sodium-dependent serotonin transporter 5HT transporter 5HTT Solute carrier family 6 member 4
External Links
UniProt	Q60857
EMBL	AF013604 Y08870 Y08871 Y08872 Y08873 Y08874 Y08875 Y08876 Y08877 Y08878 Y08879 Y08880 AL603842 U26452 X66119
CCDS	CCDS25074.1
RefSeq	NP_034614.2 XP_006532362.1 XP_006532363.1 XP_006532364.1
UniGene	Mm.300318
ProteinModelPortal	Q60857
SMR	Q60857
BioGrid	200481
DIP	DIP-60923N
STRING	10090.ENSMUSP00000021195
BindingDB	Q60857
ChEMBL	CHEMBL4642
PhosphoSite	Q60857
PaxDb	Q60857
PRIDE	Q60857
Ensembl	ENSMUST00000021195 ENSMUST00000108402
GeneID	15567
KEGG	mmu:15567
UCSC	uc007kgf.2
CTD	6532
MGI	MGI:96285
eggNOG	COG0733
GeneTree	ENSGT00760000118857
HOGENOM	HOG000116406
HOVERGEN	HBG071421
InParanoid	Q60857
KO	K05037
OMA	TSCKNSW
OrthoDB	EOG793B71
TreeFam	TF343812
NextBio	288538
PRO	PR:Q60857
Proteomes	UP000000589
Bgee	Q60857
CleanEx	MM_HTT
ExpressionAtlas	Q60857
Genevestigator	Q60857
GO	GO:0005829 GO:0012505 GO:0010008 GO:0005887 GO:0045121 GO:0043005 GO:0005886 GO:0051015 GO:0019811 GO:0008504 GO:0050998 GO:0015222 GO:0005335 GO:0048854 GO:0071321 GO:0071310 GO:0071300 GO:0007623 GO:0007613 GO:0015844 GO:0021941 GO:0045665 GO:0046621 GO:0032227 GO:0045787 GO:0010628 GO:0051260 GO:0051259 GO:0042493 GO:0032355 GO:0001666 GO:0007584 GO:0009636 GO:0006837 GO:0051610 GO:0035176 GO:0042713 GO:0021794 GO:0042310
InterPro	IPR000175 IPR013086
PANTHER	PTHR11616
Pfam	PF03491 PF00209
PRINTS	PR01203 PR00176
PROSITE	PS00610 PS00754 PS50267

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0035176	social behavior	PMID:19208814^[1]	ECO:0000315			P	Figure 3A, Slc6a4 mutant mice showed decrease in preference with interacting mouse compared to wild type mice.	complete CACAO 2678
	GO:0046621	negative regulation of organ growth	PMID:19208814^[1]	ECO:0000315			P	Heterozygous Slc6a4 mice resulted in macrocephaly in males and females, figure 1A-C. There was increase in brain size; therefore Slc6a4 has a negative regulation on brain growth.	complete CACAO 2679
	GO:0048854	brain morphogenesis	PMID:19208814^[1]	ECO:0000315			P	Heterozygous Slc6a4 mice resulted in macrocephaly in males and females, figure 1A-C. There was increase in brain size; therefore Slc6a4 has a negative regulation on brain growth.	complete CACAO 2680
involved_in	GO:0048854	brain morphogenesis	PMID:19208814^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	PMID:19208814^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090067	regulation of thalamus size	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31645	P	Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:19208814^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	PMID:19208814^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:19208814^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O08586	P	Seeded From UniProt	complete
involved_in	GO:0051610	serotonin uptake	PMID:9547354^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051610	serotonin uptake	PMID:17452640^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31652	P	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31652	F	Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	PMID:17452640^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z0J4	F	Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:19308295^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31645	C	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:19308295^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006837	serotonin transport	PMID:19308295^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31645	C	Seeded From UniProt	complete
involved_in	GO:0098810	neurotransmitter reuptake	PMID:9037532^[5]	ECO:0006063	over expression analysis evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051610	serotonin uptake	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010414 MGI:MGI:96285 PANTHER:PTN002481010 RGD:3714 UniProtKB:P31645 WB:WBGene00003387	P	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002481010 UniProtKB:F1MLI6 UniProtKB:Q9XT49	F	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002481010 RGD:3714	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0035969 FB:FBgn0039915 MGI:MGI:1336891 MGI:MGI:1336892 MGI:MGI:95627 MGI:MGI:95760 PANTHER:PTN000177662 RGD:3714 RGD:3715 RGD:620533 RGD:621822 UniProtKB:P31645 UniProtKB:Q01959 UniProtKB:Q9Y345	C	Seeded From UniProt	complete
enables	GO:0005335	serotonin:sodium symporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010414 PANTHER:PTN002481010 RGD:3714 UniProtKB:P31645 WB:WBGene00003387	F	Seeded From UniProt	complete
part_of	GO:0099154	serotonergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	C	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	C	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090067	regulation of thalamus size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071321	cellular response to cGMP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071310	cellular response to organic substance	PMID:18794345^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051610	serotonin uptake	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051610	serotonin uptake	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	C	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042713	sperm ejaculation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042310	vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032227	negative regulation of synaptic transmission, dopaminergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021941	negative regulation of cerebellar granule cell precursor proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
enables	GO:0019811	cocaine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	F	Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	F	Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	F	Seeded From UniProt	complete
enables	GO:0017022	myosin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015844	monoamine transport	PMID:16024787^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014064	positive regulation of serotonin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	C	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009636	response to toxic substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	P	Seeded From UniProt	complete
enables	GO:0008504	monoamine transmembrane transporter activity	PMID:16024787^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006837	serotonin transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006837	serotonin transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	C	Seeded From UniProt	complete
enables	GO:0005335	serotonin:sodium symporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P31645	F	Seeded From UniProt	complete
enables	GO:0005335	serotonin:sodium symporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3714	F	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015293	P	Seeded From UniProt	complete
part_of	GO:0099154	serotonergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	C	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	C	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	C	Seeded From UniProt	complete
involved_in	GO:0071321	cellular response to cGMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0051610	serotonin uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	F	Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	F	Seeded From UniProt	complete
involved_in	GO:0042713	sperm ejaculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0032227	negative regulation of synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0021941	negative regulation of cerebellar granule cell precursor proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
enables	GO:0019811	cocaine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	F	Seeded From UniProt	complete
enables	GO:0017075	syntaxin-1 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	F	Seeded From UniProt	complete
enables	GO:0017022	myosin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	F	Seeded From UniProt	complete
involved_in	GO:0014064	positive regulation of serotonin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	C	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0006837	serotonin transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	C	Seeded From UniProt	complete
enables	GO:0005335	serotonin:sodium symporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31652 ensembl:ENSRNOP00000004717	P	Seeded From UniProt	complete
involved_in	GO:0090067	regulation of thalamus size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	P	Seeded From UniProt	complete
involved_in	GO:0051610	serotonin uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	C	Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	F	Seeded From UniProt	complete
involved_in	GO:0015844	monoamine transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	P	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	C	Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	P	Seeded From UniProt	complete
enables	GO:0008504	monoamine transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	C	Seeded From UniProt	complete
enables	GO:0005335	serotonin:sodium symporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31645 ensembl:ENSP00000261707	F	Seeded From UniProt	complete
enables	GO:0005328	neurotransmitter:sodium symporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037272	F	Seeded From UniProt	complete
enables	GO:0005335	serotonin:sodium symporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013086	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013086	C	Seeded From UniProt	complete
involved_in	GO:0006836	neurotransmitter transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013086	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000175	C	Seeded From UniProt	complete
enables	GO:0015293	symporter activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0769	F	Seeded From UniProt	complete
involved_in	GO:0006836	neurotransmitter transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0532	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Page, DT et al. (2009) Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc. Natl. Acad. Sci. U.S.A. 106 1989-94 PubMed GONUTS page
↑ Bengel, D et al. (1998) Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol. Pharmacol. 53 649-55 PubMed GONUTS page
↑ ^3.0 ^3.1 Chanrion, B et al. (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc. Natl. Acad. Sci. U.S.A. 104 8119-24 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Asada, M et al. (2009) Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia 11 408-17 PubMed GONUTS page
↑ Chang, AS et al. (1996) Cloning and expression of the mouse serotonin transporter. Brain Res. Mol. Brain Res. 43 185-92 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Arnold, SJ et al. (2008) The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev. 22 2479-84 PubMed GONUTS page
↑ ^8.0 ^8.1 Jiang, W et al. (2005) IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. Mol. Cell. Biol. 25 6496-508 PubMed GONUTS page

[PMID:19208814-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Page, DT et al. (2009) Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc. Natl. Acad. Sci. U.S.A. 106 1989-94 PubMed GONUTS page

[PMID:9547354-2] Bengel, D et al. (1998) Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol. Pharmacol. 53 649-55 PubMed GONUTS page

[PMID:17452640-3] 3.0 ^3.1 Chanrion, B et al. (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc. Natl. Acad. Sci. U.S.A. 104 8119-24 PubMed GONUTS page

[PMID:19308295-4] 4.0 ^4.1 ^4.2 Asada, M et al. (2009) Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia 11 408-17 PubMed GONUTS page

[PMID:9037532-5] Chang, AS et al. (1996) Cloning and expression of the mouse serotonin transporter. Brain Res. Mol. Brain Res. 43 185-92 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18794345-7] Arnold, SJ et al. (2008) The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev. 22 2479-84 PubMed GONUTS page

[PMID:16024787-8] 8.0 ^8.1 Jiang, W et al. (2005) IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. Mol. Cell. Biol. 25 6496-508 PubMed GONUTS page

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