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MOUSE:SC6A3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Slc6a3 (synonyms: Dat, Dat1)
Protein Name(s) Sodium-dependent dopamine transporter

DA transporter DAT Solute carrier family 6 member 3

External Links
UniProt Q61327
EMBL AF109072
BC054119
AH003328
U16265
CCDS CCDS26632.1
RefSeq NP_034150.1
XP_006517145.1
UniGene Mm.41993
ProteinModelPortal Q61327
SMR Q61327
BioGrid 199053
DIP DIP-41828N
IntAct Q61327
MINT MINT-576974
BindingDB Q61327
ChEMBL CHEMBL2799
PhosphoSite Q61327
PaxDb Q61327
PRIDE Q61327
Ensembl ENSMUST00000022100
GeneID 13162
KEGG mmu:13162
UCSC uc007rdn.1
CTD 6531
MGI MGI:94862
eggNOG COG0733
GeneTree ENSGT00760000118857
HOGENOM HOG000116406
HOVERGEN HBG071421
InParanoid Q61327
KO K05036
OMA MTLESMP
OrthoDB EOG793B71
PhylomeDB Q61327
TreeFam TF343812
Reactome REACT_231512
REACT_253228
NextBio 283234
PRO PR:Q61327
Proteomes UP000000589
Bgee Q61327
Genevestigator Q61327
GO GO:0030424
GO:0005887
GO:0043025
GO:0035240
GO:0005329
GO:0005330
GO:0008144
GO:0008504
GO:0047485
GO:0021984
GO:0007568
GO:0098655
GO:0042416
GO:0042420
GO:0015872
GO:0007595
GO:0007626
GO:0015844
GO:0040018
GO:0060134
GO:0042053
GO:0051591
GO:0042220
GO:0042493
GO:0045471
GO:0010039
GO:0035094
GO:0007608
InterPro IPR000175
IPR002436
PANTHER PTHR11616
Pfam PF00209
PRINTS PR01202
PR00176
PROSITE PS00610
PS00754
PS50267

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0009986

cell surface

PMID:21399631[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

PMID:19357284[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8R191

F

Seeded From UniProt

complete

involved_in

GO:0001504

neurotransmitter uptake

PMID:8628395[3]

ECO:0001225

knockout evidence used in manual assertion

P

  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002614485
RGD:3715
UniProtKB:Q01959

C

Seeded From UniProt

complete

enables

GO:0035240

dopamine binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94862
PANTHER:PTN002614485

F

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94862
PANTHER:PTN002614485
UniProtKB:Q01959

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94862
PANTHER:PTN002614485
UniProtKB:Q01959

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035969
FB:FBgn0039915
MGI:MGI:1336891
MGI:MGI:1336892
MGI:MGI:95627
MGI:MGI:95760
PANTHER:PTN000177662
RGD:3714
RGD:3715
RGD:620533
RGD:621822
UniProtKB:P31645
UniProtKB:Q01959
UniProtKB:Q9Y345

C

Seeded From UniProt

complete

enables

GO:0005330

dopamine:sodium symporter activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002614485
RGD:3715

F

Seeded From UniProt

complete

enables

GO:0005330

dopamine:sodium symporter activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94862
PANTHER:PTN002614485
RGD:3715
UniProtKB:Q01959

F

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

C

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

C

Seeded From UniProt

complete

part_of

GO:0098691

dopaminergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090494

dopamine uptake

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060134

prepulse inhibition

PMID:11150348[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

Seeded From UniProt

complete

enables

GO:0051721

protein phosphatase 2A binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051591

response to cAMP

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045471

response to ethanol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

C

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

F

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042420

dopamine catabolic process

PMID:9520487[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042416

dopamine biosynthetic process

PMID:9520487[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042220

response to cocaine

PMID:18671743[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042053

regulation of dopamine metabolic process

PMID:9520487[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042053

regulation of dopamine metabolic process

PMID:9247269[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

regulates_o_occurs_in:(EMAPA:17536)|regulates_o_occurs_in:(EMAPA:35998)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040018

positive regulation of multicellular organism growth

PMID:9247269[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

Seeded From UniProt

complete

enables

GO:0035240

dopamine binding

PMID:18671743[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:17761882[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021984

adenohypophysis development

PMID:9247269[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

results_in_development_of:(EMAPA:17515)|results_in_development_of:(EMAPA:17516)

Seeded From UniProt

complete

part_of

GO:0016600

flotillin complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015872

dopamine transport

PMID:9520487[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015872

dopamine transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015872

dopamine transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015844

monoamine transport

PMID:16024787[10]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

C

Seeded From UniProt

complete

enables

GO:0008504

monoamine transmembrane transporter activity

PMID:16024787[10]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

F

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:11150348[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:94924
MGI:MGI:99578

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:11150348[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007608

sensory perception of smell

PMID:16765459[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

has_participant:(EMAPA:32809)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007595

lactation

PMID:9247269[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

C

Seeded From UniProt

complete

enables

GO:0005330

dopamine:sodium symporter activity

PMID:9520487[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2386303

F

Seeded From UniProt

complete

enables

GO:0005330

dopamine:sodium symporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q01959

F

Seeded From UniProt

complete

enables

GO:0005330

dopamine:sodium symporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

F

Seeded From UniProt

complete

enables

GO:0002020

protease binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3715

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015293

P

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

C

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

C

Seeded From UniProt

complete

part_of

GO:0098691

dopaminergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

C

Seeded From UniProt

complete

enables

GO:0051721

protein phosphatase 2A binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

F

Seeded From UniProt

complete

involved_in

GO:0051591

response to cAMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

F

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

C

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0035094

response to nicotine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0015872

dopamine transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

P

Seeded From UniProt

complete

involved_in

GO:0010039

response to iron ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

F

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

C

Seeded From UniProt

complete

enables

GO:0005330

dopamine:sodium symporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

F

Seeded From UniProt

complete

enables

GO:0002020

protease binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23977
ensembl:ENSRNOP00000070728

F

Seeded From UniProt

complete

involved_in

GO:0090494

dopamine uptake

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

C

Seeded From UniProt

complete

part_of

GO:0016600

flotillin complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

C

Seeded From UniProt

complete

involved_in

GO:0015872

dopamine transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

P

Seeded From UniProt

complete

involved_in

GO:0015844

monoamine transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

C

Seeded From UniProt

complete

enables

GO:0008504

monoamine transmembrane transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

C

Seeded From UniProt

complete

enables

GO:0005330

dopamine:sodium symporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01959
ensembl:ENSP00000270349

F

Seeded From UniProt

complete

enables

GO:0005328

neurotransmitter:sodium symporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037272

F

Seeded From UniProt

complete

enables

GO:0005330

dopamine:sodium symporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002436

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002436

C

Seeded From UniProt

complete

involved_in

GO:0006836

neurotransmitter transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002436

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002436

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000175

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0015293

symporter activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0769

F

Seeded From UniProt

complete

involved_in

GO:0006836

neurotransmitter transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0532

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Cremona, ML et al. (2011) Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat. Neurosci. 14 469-77 PubMed GONUTS page
  2. Egaña, LA et al. (2009) Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. J. Neurosci. 29 4592-604 PubMed GONUTS page
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