MOUSE:RGS2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rgs2
Protein Name(s)	Regulator of G-protein signaling 2 RGS2
External Links
UniProt	O08849
EMBL	U67187 AF215668 AF432916 AK031603 AK077922 AK162276 BC023001
CCDS	CCDS15347.1
RefSeq	NP_033087.2
UniGene	Mm.28262
ProteinModelPortal	O08849
SMR	O08849
IntAct	O08849
MINT	MINT-4953705
STRING	10090.ENSMUSP00000115558
PhosphoSite	O08849
PRIDE	O08849
Ensembl	ENSMUST00000127206
GeneID	19735
KEGG	mmu:19735
UCSC	uc007cxg.2
CTD	5997
MGI	MGI:1098271
eggNOG	NOG252352
GeneTree	ENSGT00760000118903
HOGENOM	HOG000233512
HOVERGEN	HBG013233
InParanoid	O08849
KO	K18154
OMA	QQAFIKP
OrthoDB	EOG7VHSZ5
PhylomeDB	O08849
TreeFam	TF315837
Reactome	REACT_207651
NextBio	297172
PRO	PR:O08849
Proteomes	UP000000589
Bgee	O08849
CleanEx	MM_RGS2
Genevestigator	O08849
GO	GO:0005737 GO:0009898 GO:0005829 GO:0043005 GO:0005730 GO:0005634 GO:0005886 GO:0005096 GO:0050873 GO:0007049 GO:0007186 GO:0043951 GO:0010614 GO:0045744 GO:0043407 GO:0010519 GO:0060452 GO:0031116 GO:0071877 GO:0006417 GO:0055119 GO:0060087 GO:0007283 GO:0038032
Gene3D	1.10.196.10
InterPro	IPR016137 IPR024066
Pfam	PF00615
PRINTS	PR01301
SMART	SM00315
SUPFAM	SSF48097
PROSITE	PS50132

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41220	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41220	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41220	F		Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41220	P		Seeded From UniProt	complete
involved_in	GO:0140194	negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process	PMID:21291891^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060452	positive regulation of cardiac muscle contraction	PMID:19127022^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060452	positive regulation of cardiac muscle contraction	PMID:21291891^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	PMID:19127022^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	PMID:19127022^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:19127022^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010614	negative regulation of cardiac muscle hypertrophy	PMID:19127022^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010519	negative regulation of phospholipase activity	PMID:19127022^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:21291891^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:14581517^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19127022^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19127022^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060087	relaxation of vascular smooth muscle	PMID:14608379^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900924	negative regulation of glycine import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050873	brown fat cell differentiation	PMID:18492766^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000136)	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043951	negative regulation of cAMP-mediated signaling	PMID:21164481^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017148	negative regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41220	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41220	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41220	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41220	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621665	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41220	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41220	F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41220	F		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41220 ensembl:ENSP00000235382	F		Seeded From UniProt	complete
involved_in	GO:1900924	negative regulation of glycine import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
involved_in	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
involved_in	GO:0060135	maternal process involved in female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	F		Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	C		Seeded From UniProt	complete
involved_in	GO:0030728	ovulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	C		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	C		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHX0 ensembl:ENSRNOP00000005156	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R939 ensembl:ENSP00000235382	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034947	F		Seeded From UniProt	complete
involved_in	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034947	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	PMID:11342430^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11342430^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:11342430^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Chakir, K et al. (2011) RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J. Mol. Cell. Cardiol. 50 1000-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Takimoto, E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J. Clin. Invest. 119 408-20 PubMed GONUTS page
↑ Pang, AL et al. () Identification of differentially expressed genes in mouse spermatogenesis. J. Androl. 24 899-911 PubMed GONUTS page
↑ Tang, KM et al. (2003) Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat. Med. 9 1506-12 PubMed GONUTS page
↑ Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page
↑ Song, Y et al. (2010) CRTC3 links catecholamine signalling to energy balance. Nature 468 933-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Nagata, Y et al. (2001) A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood 97 3051-60 PubMed GONUTS page

[PMID:21291891-1] 1.0 ^1.1 ^1.2 Chakir, K et al. (2011) RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J. Mol. Cell. Cardiol. 50 1000-7 PubMed GONUTS page

[PMID:19127022-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Takimoto, E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J. Clin. Invest. 119 408-20 PubMed GONUTS page

[PMID:14581517-3] Pang, AL et al. () Identification of differentially expressed genes in mouse spermatogenesis. J. Androl. 24 899-911 PubMed GONUTS page

[PMID:14608379-4] Tang, KM et al. (2003) Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat. Med. 9 1506-12 PubMed GONUTS page

[PMID:18492766-5] Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page

[PMID:21164481-6] Song, Y et al. (2010) CRTC3 links catecholamine signalling to energy balance. Nature 468 933-9 PubMed GONUTS page

[PMID:11342430-7] 7.0 ^7.1 ^7.2 Nagata, Y et al. (2001) A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood 97 3051-60 PubMed GONUTS page

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MOUSE:RGS2

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