MOUSE:RDH10

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rdh10
Protein Name(s)	Retinol dehydrogenase 10
External Links
UniProt	Q8VCH7
EMBL	AF456767 BC019796
CCDS	CCDS14830.1
RefSeq	NP_598593.1
UniGene	Mm.274376
ProteinModelPortal	Q8VCH7
SMR	Q8VCH7
IntAct	Q8VCH7
MINT	MINT-4119572
PhosphoSite	Q8VCH7
MaxQB	Q8VCH7
PaxDb	Q8VCH7
PRIDE	Q8VCH7
Ensembl	ENSMUST00000027053
GeneID	98711
KEGG	mmu:98711
UCSC	uc007ajm.1
CTD	157506
MGI	MGI:1924238
eggNOG	COG1028
GeneTree	ENSGT00540000069900
HOVERGEN	HBG051352
InParanoid	Q8VCH7
KO	K11151
OMA	MNNNEAK
OrthoDB	EOG7Z3F50
PhylomeDB	Q8VCH7
TreeFam	TF312837
BRENDA	1.1.1.105
Reactome	REACT_188277
UniPathway	UPA00912
NextBio	353589
PRO	PR:Q8VCH7
Proteomes	UP000000589
Bgee	Q8VCH7
CleanEx	MM_RDH10
Genevestigator	Q8VCH7
GO	GO:0044297 GO:0005789 GO:0016021 GO:0016020 GO:0052650 GO:0004745 GO:0060449 GO:0043583 GO:0031076 GO:0035115 GO:0048568 GO:0048703 GO:0008406 GO:0001701 GO:0001656 GO:0014032 GO:0043584 GO:0009887 GO:0060431 GO:0042574 GO:0002138 GO:0007601
Gene3D	3.40.50.720
InterPro	IPR002198 IPR002347 IPR016040 IPR020904
Pfam	PF00106
PIRSF	PIRSF000126
PRINTS	PR00081 PR00080
PROSITE	PS00061

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005811	lipid droplet	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029994 PANTHER:PTN001549090 UniProtKB:Q7Z5P4 UniProtKB:Q8NBQ5 WB:WBGene00000967	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900054	positive regulation of retinoic acid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727793	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060449	bud elongation involved in lung branching	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060431	primary lung bud formation	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048703	embryonic viscerocranium morphogenesis	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048568	embryonic organ development	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043584	nose development	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043583	ear development	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727793	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042574	retinal metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042572	retinol metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035115	embryonic forelimb morphogenesis	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031076	embryonic camera-type eye development	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZV5	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:17473173^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014032	neural crest cell development	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008406	gonad development	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:17383)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007601	visual perception	PMID:12407145^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZV5	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZV5	C		Seeded From UniProt	complete
enables	GO:0004745	retinol dehydrogenase activity	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004745	retinol dehydrogenase activity	PMID:12407145^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZV5	F		Seeded From UniProt	complete
enables	GO:0004745	retinol dehydrogenase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZV5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002138	retinoic acid biosynthetic process	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:17473173^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
involved_in	GO:1900054	positive regulation of retinoic acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZF7 ensembl:ENSRNOP00000009096	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZF7 ensembl:ENSRNOP00000009096	C		Seeded From UniProt	complete
involved_in	GO:0042574	retinal metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZV5 ensembl:ENSP00000240285	P		Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZV5 ensembl:ENSP00000240285	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZV5 ensembl:ENSP00000240285	C		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZV5 ensembl:ENSP00000240285	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZV5 ensembl:ENSP00000240285	C		Seeded From UniProt	complete
enables	GO:0004745	retinol dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZV5 ensembl:ENSP00000240285	F		Seeded From UniProt	complete
involved_in	GO:0002138	retinoic acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032970	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020904	F		Seeded From UniProt	complete
enables	GO:0052650	NADP-retinol dehydrogenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032970	F		Seeded From UniProt	complete
enables	GO:0052650	NADP-retinol dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.300	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00912	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 Sandell, LL et al. (2007) RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev. 21 1113-24 PubMed GONUTS page
↑ ^3.0 ^3.1 Wu, BX et al. (2002) Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest. Ophthalmol. Vis. Sci. 43 3365-72 PubMed GONUTS page

[PMID:21873635-1] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17473173-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 Sandell, LL et al. (2007) RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev. 21 1113-24 PubMed GONUTS page

[PMID:12407145-3] 3.0 ^3.1 Wu, BX et al. (2002) Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest. Ophthalmol. Vis. Sci. 43 3365-72 PubMed GONUTS page

[1]

[2]

[3]

MOUSE:RDH10

Contents

Annotations

Notes

References

a

b

c

e

g

i

l

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools