MOUSE:Q5SVI6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gck (ECO:0000313 with EMBL:BAJ19147.1, ECO:0000313 with MGI:MGI:1270854)
Protein Name(s)	Glucokinase (ECO:0000313 with EMBL:BAJ19147.1) Glucokinase, isoform CRA_a (ECO:0000313 with EMBL:EDL40567.1)
External Links
UniProt	Q5SVI6
EMBL	AB255658 AB255659 CH466574
RefSeq	NP_001274315.1
UniGene	Mm.220358
SMR	Q5SVI6
GeneID	103988
KEGG	mmu:103988
UCSC	uc007hxm.1
CTD	2645
MGI	MGI:1270854
GeneTree	ENSGT00390000017159
HOGENOM	HOG000162670
HOVERGEN	HBG000142
KO	K12407
OMA	EDHQCEV
GO	GO:0005829 GO:0005739 GO:0005634 GO:0005524 GO:0004340 GO:0046835 GO:0001678 GO:0051156 GO:0042593 GO:0006006 GO:0006096 GO:0006739 GO:0032024 GO:0050796 GO:0043266
InterPro	IPR001312 IPR022673 IPR019807 IPR022672
PANTHER	PTHR19443
Pfam	PF00349 PF03727
PRINTS	PR00475
PROSITE	PS00378

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004340	glucokinase activity	PMID:23291412	ECO:0000315			F		Figure 1 a. shows higher blood glucose levels in mice with the Gck knockdown then in those mice with wild type Gck.	complete CACAO 10091
	GO:0004340	glucokinase activity	PMID:23085254	ECO:0000315			F		Figure 1 a. shows that the Gck knockdown mice have higher blood glucose levels then in those mice with wild type Gck genotype after 2 weeks of age.	complete CACAO 10094
	GO:0004340	glucokinase activity	PMID:10512368	ECO:0000315			F		Figure 1 a & b show an increase in the glucose phosoralation capacity of mice infused with the adenovirus containing mouse GK cDNA as opposed to mice infused with adenovirus containing either a bacterial beta-galactosidase gene or a 2.4-kb B a mHI cDNA fragment encoding full-length human GK with impaired the catalytic activity due to a point mutation.	complete CACAO 10109
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0001678	C		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004396	P		Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004396	P		Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004340	P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	P		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039073	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807 InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR039073	F		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR022672 InterPro:IPR022673	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019807	P		Seeded From UniProt	complete
enables	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039073	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0324	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000120812	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000120812	F		Seeded From UniProt	complete
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References

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