MOUSE:PRKX

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prkx (synonyms: Pkare)
Protein Name(s)	cAMP-dependent protein kinase catalytic subunit PRKX PrKX Protein kinase X Protein kinase X-linked Serine/threonine-protein kinase PRKX PKA-related protein kinase
External Links
UniProt	Q922R0
EMBL	AK034681 AK036432 AK037141 AK039088 AK081548 AK139510 AK150588 AK154447 AK169322 AJ238004 AL714017 BC006875
CCDS	CCDS30248.1
RefSeq	NP_058675.1
UniGene	Mm.290338
ProteinModelPortal	Q922R0
SMR	Q922R0
PhosphoSite	Q922R0
MaxQB	Q922R0
PRIDE	Q922R0
Ensembl	ENSMUST00000036333
GeneID	19108
KEGG	mmu:19108
UCSC	uc009tqp.2
CTD	5613
MGI	MGI:1309999
eggNOG	COG0515
GeneTree	ENSGT00770000120454
HOGENOM	HOG000233033
HOVERGEN	HBG108317
InParanoid	Q922R0
KO	K04345
OMA	QKILACK
OrthoDB	EOG7VX8WD
PhylomeDB	Q922R0
TreeFam	TF313399
NextBio	295670
PRO	PR:Q922R0
Proteomes	UP000000589
Bgee	Q922R0
CleanEx	MM_PRKX
ExpressionAtlas	Q922R0
Genevestigator	Q922R0
GO	GO:0005737 GO:0005634 GO:0005524 GO:0004691 GO:0004674 GO:0001525 GO:0007155 GO:0031589 GO:0043542 GO:0001935 GO:0060562 GO:0060993 GO:0030099 GO:0018105 GO:0046777 GO:0030155 GO:0030334 GO:2000696
InterPro	IPR000961 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000696	regulation of epithelial cell differentiation involved in kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0060993	kidney morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0060562	epithelial tube morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0031589	cell-substrate adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0030099	myeloid cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:21684272^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21684272^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21684272^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004691	cAMP-dependent protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51817	F	Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	PMID:21684272^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21684272^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000696	regulation of epithelial cell differentiation involved in kidney development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060993	kidney morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060562	epithelial tube morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043542	endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031589	cell-substrate adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030155	regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030099	myeloid cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	C	Seeded From UniProt	complete
enables	GO:0004691	cAMP-dependent protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10729225^[2]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
acts_upstream_of_or_within	GO:0001935	endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51817	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Li, X et al. (2011) PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. Dev. Biol. 356 475-85 PubMed GONUTS page
↑ Blaschke, RJ et al. (2000) A novel murine PKA-related protein kinase involved in neuronal differentiation. Genomics 64 187-94 PubMed GONUTS page

[PMID:21684272-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Li, X et al. (2011) PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. Dev. Biol. 356 475-85 PubMed GONUTS page

[PMID:10729225-2] Blaschke, RJ et al. (2000) A novel murine PKA-related protein kinase involved in neuronal differentiation. Genomics 64 187-94 PubMed GONUTS page

[1]

[2]

MOUSE:PRKX

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