MOUSE:PLK1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Plk1 (synonyms: Plk)
Protein Name(s)	Serine/threonine-protein kinase PLK1 Polo-like kinase 1 PLK-1 Serine/threonine-protein kinase 13 STPK13
External Links
UniProt	Q07832
EMBL	L06144 U01063 L19558 BC006880
CCDS	CCDS21812.1
PIR	A47545 A54596
RefSeq	NP_035251.3
UniGene	Mm.16525
PDB	5DMS 5DMV 5DNJ
PDBsum	5DMS 5DMV 5DNJ
ProteinModelPortal	Q07832
SMR	Q07832
BioGrid	202250
DIP	DIP-56722N
IntAct	Q07832
MINT	MINT-4596676
STRING	10090.ENSMUSP00000033154
iPTMnet	Q07832
PhosphoSite	Q07832
EPD	Q07832
PaxDb	Q07832
PRIDE	Q07832
Ensembl	ENSMUST00000033154
GeneID	18817
KEGG	mmu:18817
UCSC	uc009joo.2
CTD	5347
MGI	MGI:97621
eggNOG	KOG0575 ENOG410XQBP
HOGENOM	HOG000248546
HOVERGEN	HBG001843
InParanoid	Q07832
KO	K06631
OMA	KRYMTEH
OrthoDB	EOG78M01K
PhylomeDB	Q07832
TreeFam	TF101089
BRENDA	2.7.11.21
Reactome	R-MMU-156711 R-MMU-162658 R-MMU-174178 R-MMU-176412 R-MMU-176417 R-MMU-2299718 R-MMU-2467813 R-MMU-2500257 R-MMU-2565942 R-MMU-2980767 R-MMU-380259 R-MMU-380270 R-MMU-5620912 R-MMU-5663220 R-MMU-68877 R-MMU-68881 R-MMU-68884 R-MMU-69273
NextBio	295174
PRO	PR:Q07832
Proteomes	UP000000589
Bgee	Q07832
CleanEx	MM_PLK1
ExpressionAtlas	Q07832
Genevisible	Q07832
GO	GO:0005813 GO:0000785 GO:0000942 GO:0000780 GO:0005737 GO:0000776 GO:0015630 GO:0030496 GO:0005730 GO:0005634 GO:0005819 GO:0005876 GO:0051233 GO:0000922 GO:0000795 GO:0010997 GO:0005524 GO:0008017 GO:0004672 GO:0019901 GO:0004674 GO:0007092 GO:0051297 GO:0045184 GO:0016321 GO:0031572 GO:0000086 GO:0045143 GO:0001578 GO:0000281 GO:0007067 GO:0000070 GO:0007094 GO:0043066 GO:0045736 GO:0000122 GO:0018105 GO:0010800 GO:0032436 GO:0045862 GO:0051443 GO:0031648 GO:0071168 GO:0006468 GO:0016567 GO:0007346 GO:0030071 GO:1901673 GO:0043393 GO:0070194
Gene3D	3.30.1120.30
InterPro	IPR011009 IPR000959 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069 PF00659
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS50078 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004672	protein kinase activity	PMID:21637952^[1]	ECO:0000314			F	Fig 2(a) - Wild type Plk1 phosphorylates UAP56.	complete CACAO 11751
	GO:0006468	protein phosphorylation	PMID:21637952^[1]	ECO:0000315			P	Fig 2(b) - Phosphorylation of UAP56 is dependent upon levels of Plk1.	complete CACAO 11752
involved_in	GO:0090435	protein localization to nuclear envelope	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0051081	nuclear envelope disassembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:1904668	positive regulation of ubiquitin protein ligase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:22405274^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
involved_in	GO:0001578	microtubule bundle formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000679869 PomBase:SPAC23C11.16 SGD:S000004603 UniProtKB:P53350 UniProtKB:Q9H4B4	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003124 MGI:MGI:97621 PANTHER:PTN000679869 UniProtKB:P53350 UniProtKB:Q9H4B4 UniProtKB:Q9NYY3 WB:WBGene00004042 dictyBase:DDB_G0274503	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003124 MGI:MGI:97621 PANTHER:PTN000679869 RGD:3352 UniProtKB:Q496M5 UniProtKB:Q57YD1 UniProtKB:Q9H4B4 UniProtKB:Q9NYY3 WB:WBGene00004042 WB:WBGene00004043	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003124 MGI:MGI:3026984 MGI:MGI:97621 PANTHER:PTN000679869 PomBase:SPAC23C11.16 RGD:3352 SGD:S000004603 UniProtKB:C8VMZ9 UniProtKB:P53350 UniProtKB:Q5ABG0 UniProtKB:Q9H4B4 WB:WBGene00004042	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003124 FB:FBgn0026371 MGI:MGI:101783 MGI:MGI:109604 MGI:MGI:1099790 MGI:MGI:97621 PANTHER:PTN000757484 PomBase:SPAC23C11.16 RGD:620760 UniProtKB:O00444 UniProtKB:P53350 UniProtKB:Q9H4B4 UniProtKB:Q9NYY3	F	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003124 PANTHER:PTN000679869 PomBase:SPAC23C11.16 RGD:3352 SGD:S000004603 UniProtKB:P53350 dictyBase:DDB_G0274503	C	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003124 MGI:MGI:109604 MGI:MGI:1099790 PANTHER:PTN000679869 SGD:S000004603 UniProtKB:C8VMZ9 UniProtKB:P53350 UniProtKB:Q9H4B4 UniProtKB:Q9NYY3 WB:WBGene00004042 ZFIN:ZDB-GENE-021115-7	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904668	positive regulation of ubiquitin protein ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901673	regulation of mitotic spindle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090435	protein localization to nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071168	protein localization to chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070194	synaptonemal complex disassembly	PMID:22854038^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3352	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051081	nuclear envelope disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045862	positive regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045184	establishment of protein localization	PMID:18331714^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045143	homologous chromosome segregation	PMID:25533956^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043393	regulation of protein binding	PMID:27979967^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043393	regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040038	polar body extrusion after meiotic divisions	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3352	P	Seeded From UniProt	complete
part_of	GO:0034451	centriolar satellite	PMID:27979967^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033365	protein localization to organelle	PMID:27979967^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032465	regulation of cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:23036704^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:F7HSC1	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030071	regulation of mitotic metaphase/anaphase transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:27979967^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:27979967^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016321	female meiosis chromosome segregation	PMID:25533956^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
enables	GO:0010997	anaphase-promoting complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007098	centrosome cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007094	mitotic spindle assembly checkpoint	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:22854038^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q62673	P	Seeded From UniProt	complete
colocalizes_with	GO:0005876	spindle microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:27979967^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3352	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3352	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:27979967^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:27979967^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:22854038^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001578	microtubule bundle formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
part_of	GO:0000942	condensed nuclear chromosome outer kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:18331714^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3352	C	Seeded From UniProt	complete
part_of	GO:0000795	synaptonemal complex	PMID:22854038^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:22854038^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000780	condensed nuclear chromosome, centromeric region	PMID:22854038^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:25533956^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	C	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000281	mitotic cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000278	mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000086	G2/M transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000070	mitotic sister chromatid segregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P53350	P	Seeded From UniProt	complete
involved_in	GO:1904776	regulation of protein localization to cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:1904668	positive regulation of ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:1901673	regulation of mitotic spindle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0090435	protein localization to nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0051443	positive regulation of ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
part_of	GO:0051233	spindle midzone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
involved_in	GO:0051081	nuclear envelope disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0045862	positive regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0043393	regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	F	Seeded From UniProt	complete
involved_in	GO:0032465	regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
involved_in	GO:0030071	regulation of mitotic metaphase/anaphase transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	F	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
enables	GO:0010997	anaphase-promoting complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	F	Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	F	Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
part_of	GO:0005876	spindle microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	F	Seeded From UniProt	complete
involved_in	GO:0001578	microtubule bundle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
part_of	GO:0000942	condensed nuclear chromosome outer kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	C	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	F	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P53350 ensembl:ENSP00000300093	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C	Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Xiong, F et al. (2012) Plk1-mediated phosphorylation of UAP56 regulates the stability of UAP56. Mol. Biol. Rep. 39 1935-42 PubMed GONUTS page
↑ Mondal, G et al. (2012) Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. Mol. Cell 45 680-95 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Jordan, PW et al. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J. Cell. Sci. 125 5061-72 PubMed GONUTS page
↑ ^5.0 ^5.1 Wang, X et al. (2008) sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev. Cell 14 331-41 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Kim, J et al. (2015) Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature 517 466-71 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Zhang, B et al. (2017) DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. J. Biol. Chem. 292 1351-1360 PubMed GONUTS page
↑ Izumiyama, T et al. (2012) A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Gene 511 202-17 PubMed GONUTS page

[PMID:21637952-1] 1.0 ^1.1 Xiong, F et al. (2012) Plk1-mediated phosphorylation of UAP56 regulates the stability of UAP56. Mol. Biol. Rep. 39 1935-42 PubMed GONUTS page

[PMID:22405274-2] Mondal, G et al. (2012) Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. Mol. Cell 45 680-95 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22854038-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Jordan, PW et al. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J. Cell. Sci. 125 5061-72 PubMed GONUTS page

[PMID:18331714-5] 5.0 ^5.1 Wang, X et al. (2008) sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev. Cell 14 331-41 PubMed GONUTS page

[PMID:25533956-6] 6.0 ^6.1 ^6.2 Kim, J et al. (2015) Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature 517 466-71 PubMed GONUTS page

[PMID:27979967-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Zhang, B et al. (2017) DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. J. Biol. Chem. 292 1351-1360 PubMed GONUTS page

[PMID:23036704-8] Izumiyama, T et al. (2012) A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Gene 511 202-17 PubMed GONUTS page

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MOUSE:PLK1

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