MOUSE:PEDF

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Serpinf1 (synonyms: Pedf, Sdf3)
Protein Name(s)	Pigment epithelium-derived factor PEDF Caspin Serpin F1 Stromal cell-derived factor 3 SDF-3
External Links
UniProt	P97298
EMBL	D50460 AF036164 D87975 AF017055 AF017051 AF017052 AF017053 AF017054 AF017057 BC019852
CCDS	CCDS25045.1
RefSeq	NP_035470.3
UniGene	Mm.2044
ProteinModelPortal	P97298
SMR	P97298
MEROPS	I04.979
PhosphoSite	P97298
MaxQB	P97298
PaxDb	P97298
PRIDE	P97298
Ensembl	ENSMUST00000000769
GeneID	20317
KEGG	mmu:20317
UCSC	uc007kdp.1
CTD	5176
MGI	MGI:108080
eggNOG	COG4826
GeneTree	ENSGT00770000120524
HOGENOM	HOG000115489
HOVERGEN	HBG106911
InParanoid	P97298
OMA	LNCKIAQ
OrthoDB	EOG7K3TMD
PhylomeDB	P97298
TreeFam	TF317350
NextBio	298103
PRO	PR:P97298
Proteomes	UP000000589
Bgee	P97298
ExpressionAtlas	P97298
Genevestigator	P97298
GO	GO:0043203 GO:0005604 GO:0005576 GO:0005615 GO:0070062 GO:0042470 GO:0048471 GO:0004867 GO:0007568 GO:0071279 GO:0071549 GO:0071333 GO:0071300 GO:0001822 GO:0016525 GO:0010951 GO:0010596 GO:0060770 GO:0050728 GO:1901215 GO:0042698 GO:0050769 GO:0010976 GO:0030162 GO:0010447 GO:0046685 GO:0060041 GO:0007614
InterPro	IPR023795 IPR023796 IPR000215
PANTHER	PTHR11461
Pfam	PF00079
SMART	SM00093
SUPFAM	SSF56574
PROSITE	PS00284

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001568	blood vessel development	PMID:12072560^[1]	ECO:0000314			P		Figure 3B shows reduced vascularization compared to the control in PEDF treated mice by measuring endothelial cell numbers.	complete CACAO 10698
part_of	GO:0005615	extracellular space	PMID:24006456^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P36955	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:12632345^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:9614124^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028988 FB:FBgn0265137 PANTHER:PTN000156123 RGD:3249 UniProtKB:P05121 UniProtKB:P29508 UniProtKB:P35237 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q9UIV8	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0015586 FB:FBgn0028986 FB:FBgn0031973 FB:FBgn0262057 FB:FBgn0265137 MGI:MGI:108080 MGI:MGI:1915304 MGI:MGI:87963 MGI:MGI:88278 MGI:MGI:894696 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:2069 RGD:3249 RGD:3326 RGD:3747 RGD:3748 RGD:619833 RGD:631369 RGD:735225 UniProtKB:P01008 UniProtKB:P01009 UniProtKB:P01011 UniProtKB:P01019 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P08697 UniProtKB:P50453 UniProtKB:Q90935 UniProtKB:Q99574 UniProtKB:Q9TTE1	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0028983 FB:FBgn0028988 FB:FBgn0028990 FB:FBgn0265137 MGI:MGI:101780 MGI:MGI:106603 MGI:MGI:1277952 MGI:MGI:2445361 MGI:MGI:2683293 MGI:MGI:891970 MGI:MGI:894696 MGI:MGI:97608 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:3249 RGD:3326 RGD:3748 RGD:619817 RGD:619896 RGD:619897 UniProtKB:P01009 UniProtKB:P01012 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P05155 UniProtKB:P07093 UniProtKB:P08697 UniProtKB:P35237 UniProtKB:P48594 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q3ZEJ6 UniProtKB:Q86WD7 UniProtKB:Q90935 UniProtKB:Q96P63 UniProtKB:Q99574 UniProtKB:Q9TTE1 UniProtKB:Q9UIV8 WB:WBGene00005643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	PMID:12740569^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2664515	P	regulates_o_occurs_in:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050769	positive regulation of neurogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	C		Seeded From UniProt	complete
part_of	GO:0043203	axon hillock	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010596	negative regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007614	short-term memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15020256^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	C		Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P36955	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631369	C		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36955 ensembl:ENSP00000254722	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36955 ensembl:ENSP00000254722	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36955 ensembl:ENSP00000254722	C		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0071279	cellular response to cobalt ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	C		Seeded From UniProt	complete
involved_in	GO:0046685	response to arsenic-containing substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
part_of	GO:0043203	axon hillock	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	C		Seeded From UniProt	complete
involved_in	GO:0042698	ovulation cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	C		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0010596	negative regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0010447	response to acidic pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0007614	short-term memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	C		Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	C		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80ZA3 ensembl:ENSRNOP00000004313	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000215	C		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033832	P		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033832	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Raisler, BJ et al. (2002) Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc. Natl. Acad. Sci. U.S.A. 99 8909-14 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ Abramson, LP et al. (2003) Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model. J. Pediatr. Surg. 38 336-42; discussion 336-42 PubMed GONUTS page
↑ Kozaki, K et al. (1998) Isolation, purification, and characterization of a collagen-associated serpin, caspin, produced by murine colon adenocarcinoma cells. J. Biol. Chem. 273 15125-30 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Doll, JA et al. (2003) Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat. Med. 9 774-80 PubMed GONUTS page
↑ Tombran-Tink, J & Barnstable, CJ (2004) Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone. Biochem. Biophys. Res. Commun. 316 573-9 PubMed GONUTS page

[PMID:12072560-1] Raisler, BJ et al. (2002) Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc. Natl. Acad. Sci. U.S.A. 99 8909-14 PubMed GONUTS page

[PMID:24006456-2] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:12632345-3] Abramson, LP et al. (2003) Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model. J. Pediatr. Surg. 38 336-42; discussion 336-42 PubMed GONUTS page

[PMID:9614124-4] Kozaki, K et al. (1998) Isolation, purification, and characterization of a collagen-associated serpin, caspin, produced by murine colon adenocarcinoma cells. J. Biol. Chem. 273 15125-30 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12740569-6] Doll, JA et al. (2003) Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat. Med. 9 774-80 PubMed GONUTS page

[PMID:15020256-7] Tombran-Tink, J & Barnstable, CJ (2004) Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone. Biochem. Biophys. Res. Commun. 316 573-9 PubMed GONUTS page

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MOUSE:PEDF

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