MOUSE:PAR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	F2r (synonyms: Cf2r, Par1)
Protein Name(s)	Proteinase-activated receptor 1 PAR-1 Thrombin receptor
External Links
UniProt	P30558
EMBL	L03529 U36757 U36756 AK085990 AK159282 AK160032 BC031516 AH003565
CCDS	CCDS26701.1
RefSeq	NP_034299.2
UniGene	Mm.24816
ProteinModelPortal	P30558
SMR	P30558
GuidetoPHARMACOLOGY	347
PhosphoSite	P30558
MaxQB	P30558
PRIDE	P30558
Ensembl	ENSMUST00000059193
GeneID	14062
KEGG	mmu:14062
UCSC	uc007rmn.1
CTD	2149
MGI	MGI:101802
eggNOG	NOG150457
GeneTree	ENSGT00760000119001
HOGENOM	HOG000232200
HOVERGEN	HBG108233
InParanoid	P30558
KO	K03914
OMA	VHYLFLS
OrthoDB	EOG7V49ZD
PhylomeDB	P30558
TreeFam	TF330775
Reactome	REACT_207651 REACT_220322 REACT_235286
NextBio	285032
PRO	PR:P30558
Proteomes	UP000000589
Bgee	P30558
CleanEx	MM_F2R
Genevestigator	P30558
GO	GO:0005901 GO:0016021 GO:0031594 GO:0005886 GO:0031094 GO:0045211 GO:0001965 GO:0031681 GO:0004930 GO:0032795 GO:0015057 GO:0006919 GO:0000186 GO:0002248 GO:0016265 GO:0007529 GO:0048873 GO:0006954 GO:0008285 GO:0003105 GO:0043524 GO:1900134 GO:0030168 GO:0030194 GO:0051928 GO:0030335 GO:0008284 GO:0032967 GO:0043280 GO:0007204 GO:0051482 GO:0070374 GO:0043123 GO:2000778 GO:2000484 GO:0046427 GO:0043410 GO:0014068 GO:0051281 GO:0035025 GO:0045987 GO:0045893 GO:0045907 GO:0007205 GO:0032651 GO:0051930 GO:0051209 GO:0032496 GO:0009611 GO:0007262 GO:0070493 GO:0007260
InterPro	IPR000276 IPR017452 IPR003912 IPR000935
Pfam	PF00001
PRINTS	PR00237 PR01428 PR00908
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	PMID:21414931^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0060077) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:1900134	negative regulation of renin secretion into blood stream	PMID:21859963^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:20215560^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	PMID:21859963^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0006544)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	C		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	PMID:20215560^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	PMID:20215560^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	C		Seeded From UniProt	complete
part_of	GO:0031094	platelet dense tubular network	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:20215560^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
enables	GO:0015057	thrombin-activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	F		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:20215560^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0007529	establishment of synaptic specificity at neuromuscular junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
involved_in	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:20215560^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:20215560^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	PMID:20215560^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26824	P		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000660850 RGD:2586	P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101802 MGI:MGI:101910 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q9Y2T6	P		Seeded From UniProt	complete
enables	GO:0015057	thrombin-activated receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000661114 UniProtKB:P25116	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1929509 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q99678 UniProtKB:Q9HC97 UniProtKB:Q9Y2T6	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101802 MGI:MGI:101910 MGI:MGI:2441992 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q8IYL9 UniProtKB:Q99678 UniProtKB:Q9HC97	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070493	thrombin-activated receptor signaling pathway	PMID:18398001^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88380	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051930	regulation of sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048873	homeostasis of number of cells within a tissue	PMID:18305483^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3038377	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045217	cell-cell junction maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043547	positive regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032651	regulation of interleukin-1 beta production	PMID:18305483^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3038377	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:18305483^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3038377	P		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	C		Seeded From UniProt	complete
part_of	GO:0031094	platelet dense tubular network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030194	positive regulation of blood coagulation	PMID:18305483^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030194	positive regulation of blood coagulation	PMID:18305483^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3038377	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030194	positive regulation of blood coagulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030193	regulation of blood coagulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030168	platelet activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
enables	GO:0015057	thrombin-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:18398001^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88380	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007529	establishment of synaptic specificity at neuromuscular junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	PMID:18305483^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3038377	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000186	activation of MAPKK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2586	P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0045217	cell-cell junction maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
part_of	GO:0031094	platelet dense tubular network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0030194	positive regulation of blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0030193	regulation of blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
enables	GO:0015057	thrombin-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	C		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	F		Seeded From UniProt	complete
involved_in	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25116 ensembl:ENSP00000321326	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000935	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000935	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000935 InterPro:IPR003912	P		Seeded From UniProt	complete
enables	GO:0015057	thrombin-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003912	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000935 InterPro:IPR003912 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0070493	thrombin-activated receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003912	P		Seeded From UniProt	complete
enables	GO:0032795	heterotrimeric G-protein binding	PMID:20215560^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007599	hemostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0356	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0094	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hashimotodani, Y et al. (2011) Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. J. Neurosci. 31 3104-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Höcherl, K et al. (2011) Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension 58 611-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 McCoy, KL et al. (2010) PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol. Pharmacol. 77 1005-15 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Feutz, AC et al. (2008) Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells. J. Cell. Sci. 121 1435-43 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Niessen, F et al. (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 452 654-8 PubMed GONUTS page

[PMID:21414931-1] Hashimotodani, Y et al. (2011) Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. J. Neurosci. 31 3104-9 PubMed GONUTS page

[PMID:21859963-2] 2.0 ^2.1 Höcherl, K et al. (2011) Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension 58 611-8 PubMed GONUTS page

[PMID:20215560-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 McCoy, KL et al. (2010) PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol. Pharmacol. 77 1005-15 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18398001-5] 5.0 ^5.1 Feutz, AC et al. (2008) Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells. J. Cell. Sci. 121 1435-43 PubMed GONUTS page

[PMID:18305483-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Niessen, F et al. (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 452 654-8 PubMed GONUTS page

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MOUSE:PAR1

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