MOUSE:NEK2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nek2
Protein Name(s)	Serine/threonine-protein kinase Nek2 Never in mitosis A-related kinase 2 NimA-related protein kinase 2
External Links
UniProt	O35942
EMBL	U95610 AF013166 AF007247 AK147072 AK164467
CCDS	CCDS15623.1
RefSeq	NP_035022.2
UniGene	Mm.33773 Mm.403999
ProteinModelPortal	O35942
SMR	O35942
BioGrid	201728
IntAct	O35942
PhosphoSite	O35942
PaxDb	O35942
PRIDE	O35942
Ensembl	ENSMUST00000027931
GeneID	18005
KEGG	mmu:18005
UCSC	uc007ecx.2
CTD	4751
MGI	MGI:109359
eggNOG	COG0515
GeneTree	ENSGT00760000118997
HOGENOM	HOG000233029
HOVERGEN	HBG006461
InParanoid	O35942
KO	K08857
OMA	SKCKDLK
OrthoDB	EOG715Q40
TreeFam	TF101184
Reactome	REACT_196635 REACT_243078 REACT_244487 REACT_245720
NextBio	293015
PRO	PR:O35942
Proteomes	UP000000589
Bgee	O35942
ExpressionAtlas	O35942
Genevestigator	O35942
GO	GO:0005813 GO:0000777 GO:0000794 GO:0005737 GO:0045171 GO:0005874 GO:0030496 GO:0005730 GO:0000922 GO:0005524 GO:0046872 GO:0004672 GO:0004674 GO:0001824 GO:0051299 GO:0007059 GO:0051321 GO:0000070 GO:1903126 GO:0043392 GO:0046777 GO:0006468 GO:0051988 GO:0090307
InterPro	IPR011009 IPR000719 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51955	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51955	F		Seeded From UniProt	complete
involved_in	GO:0046602	regulation of mitotic centrosome separation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:1903126	negative regulation of centriole-centriole cohesion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002884430 UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109359 PANTHER:PTN002884430 PomBase:SPAC19E9.02	P		Seeded From UniProt	complete
involved_in	GO:0046602	regulation of mitotic centrosome separation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002884430 UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029970 PANTHER:PTN002884430 PomBase:SPAC19E9.02 UniProtKB:P11837 UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109359 PANTHER:PTN002884430 SGD:S000000071 UniProtKB:P11837 UniProtKB:P51955	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029970 PANTHER:PTN002884429 UniProtKB:P51955 dictyBase:DDB_G0270814	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109359 PANTHER:PTN002884429 UniProtKB:P11837 UniProtKB:P51955	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029970 PANTHER:PTN002462863 UniProtKB:P11837 UniProtKB:P9WI63 UniProtKB:Q8NG66 dictyBase:DDB_G0270814	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904355	positive regulation of telomere capping	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903126	negative regulation of centriole-centriole cohesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090307	mitotic spindle assembly	PMID:19117032^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000353)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051973	positive regulation of telomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051299	centrosome separation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046602	regulation of mitotic centrosome separation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043392	negative regulation of DNA binding	PMID:14668482^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:15479717^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16033) part_of:(CL:0000007)	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007059	chromosome segregation	PMID:19117032^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000353)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007059	chromosome segregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:14697346^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(MGI:MGI:1861721)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:14697346^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1861721)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:14668482^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:101761)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001824	blastocyst development	PMID:19117032^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:15479717^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16033) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:15479717^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16033) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	C		Seeded From UniProt	complete
colocalizes_with	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51955	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000070	mitotic sister chromatid segregation	PMID:15479717^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16033) occurs_in:(CL:0000007)	Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
involved_in	GO:1903126	negative regulation of centriole-centriole cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
involved_in	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
involved_in	GO:0051299	centrosome separation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
involved_in	GO:0046602	regulation of mitotic centrosome separation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	C		Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	F		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51955 ensembl:ENSP00000355966	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0159	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P		Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Sonn, S et al. (2009) Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos. Mol. Reprod. Dev. 76 587-92 PubMed GONUTS page
↑ ^3.0 ^3.1 Di Agostino, S et al. (2004) Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes. Mol. Biol. Cell 15 1224-32 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Sonn, S et al. (2004) Suppression of Nek2A in mouse early embryos confirms its requirement for chromosome segregation. J. Cell. Sci. 117 5557-66 PubMed GONUTS page
↑ ^5.0 ^5.1 Yoo, JC et al. (2004) NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. Exp. Cell Res. 292 393-402 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19117032-2] 2.0 ^2.1 ^2.2 Sonn, S et al. (2009) Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos. Mol. Reprod. Dev. 76 587-92 PubMed GONUTS page

[PMID:14668482-3] 3.0 ^3.1 Di Agostino, S et al. (2004) Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes. Mol. Biol. Cell 15 1224-32 PubMed GONUTS page

[PMID:15479717-4] 4.0 ^4.1 ^4.2 ^4.3 Sonn, S et al. (2004) Suppression of Nek2A in mouse early embryos confirms its requirement for chromosome segregation. J. Cell. Sci. 117 5557-66 PubMed GONUTS page

[PMID:14697346-5] 5.0 ^5.1 Yoo, JC et al. (2004) NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. Exp. Cell Res. 292 393-402 PubMed GONUTS page

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MOUSE:NEK2

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