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MOUSE:MYF5

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Myf5 (synonyms: Myf-5)
Protein Name(s) Myogenic factor 5

Myf-5

External Links
UniProt P24699
EMBL X56182
AK044894
AK083402
CCDS CCDS24161.1
PIR S22825
RefSeq NP_032682.1
XP_006513382.1
UniGene Mm.4984
ProteinModelPortal P24699
SMR P24699
BioGrid 201641
MINT MINT-1519267
STRING 10090.ENSMUSP00000000445
PhosphoSite P24699
PRIDE P24699
Ensembl ENSMUST00000000445
GeneID 17877
KEGG mmu:17877
UCSC uc007gyz.1
CTD 4617
MGI MGI:97252
eggNOG NOG239177
GeneTree ENSGT00530000063004
HOGENOM HOG000234800
HOVERGEN HBG006429
InParanoid P24699
KO K18484
OMA DMMDGCQ
OrthoDB EOG76QFK1
PhylomeDB P24699
TreeFam TF316344
Reactome REACT_258600
NextBio 292665
PRO PR:P24699
Proteomes UP000000589
Bgee P24699
CleanEx MM_MYF5
ExpressionAtlas P24699
Genevestigator P24699
GO GO:0005634
GO:0003705
GO:0001228
GO:0043565
GO:0043010
GO:0001502
GO:0048704
GO:0030198
GO:0007517
GO:0048644
GO:0060415
GO:0001503
GO:0045944
GO:0001952
GO:0035914
GO:0007519
GO:0001756
GO:0006366
Gene3D 4.10.280.10
InterPro IPR002546
IPR011598
IPR022032
Pfam PF01586
PF00010
PF12232
SMART SM00520
SM00353
SUPFAM SSF47459
PROSITE PS50888

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1901741

positive regulation of myoblast fusion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000164853
UniProtKB:P15172

P

Seeded From UniProt

complete

involved_in

GO:0048743

positive regulation of skeletal muscle fiber development

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97276
PANTHER:PTN000898840

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97252
MGI:MGI:97275
MGI:MGI:97276
PANTHER:PTN000164853
RGD:620432
UniProtKB:P15172
UniProtKB:P15173
UniProtKB:P16075
UniProtKB:P17920
UniProtKB:Q01795
WB:WBGene00001948

P

Seeded From UniProt

complete

involved_in

GO:0045663

positive regulation of myoblast differentiation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97276
PANTHER:PTN000164853

P

Seeded From UniProt

complete

involved_in

GO:0035914

skeletal muscle cell differentiation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97252
MGI:MGI:97253
MGI:MGI:97275
PANTHER:PTN000898840
ZFIN:ZDB-GENE-980526-561

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002922
MGI:MGI:97275
MGI:MGI:97276
PANTHER:PTN000164853
RGD:620432
RGD:631429
WB:WBGene00001948

C

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97252
MGI:MGI:97253
MGI:MGI:97275
MGI:MGI:97276
PANTHER:PTN000164853
UniProtKB:P15172
UniProtKB:P15173

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97275
MGI:MGI:97276
PANTHER:PTN000164853
RGD:620432

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060415

muscle tissue morphogenesis

PMID:19531352[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97491

P

has_participant:(EMAPA:18234)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060415

muscle tissue morphogenesis

PMID:19531352[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857973
MGI:MGI:3055340

P

has_participant:(EMAPA:18234)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048704

embryonic skeletal system morphogenesis

PMID:10929709[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857219

P

has_participant:(EMAPA:18010)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048644

muscle organ morphogenesis

PMID:19531352[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98493

P

has_participant:(EMAPA:16706)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22638570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17855775[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:22638570[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043010

camera-type eye development

PMID:19531352[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857973
MGI:MGI:3055340

P

results_in_development_of:(EMAPA:18234)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035914

skeletal muscle cell differentiation

PMID:22147266[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030198

extracellular matrix organization

PMID:16554364[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857973

P

occurs_in:(EMAPA:16423)|occurs_in:(EMAPA:16426)|occurs_in:(EMAPA:16429)|occurs_in:(EMAPA:16432)|occurs_in:(EMAPA:16435)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007519

skeletal muscle tissue development

PMID:8269513[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97275

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007519

skeletal muscle tissue development

PMID:19531352[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97253

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007519

skeletal muscle tissue development

PMID:19531352[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857973
MGI:MGI:3055340

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007517

muscle organ development

PMID:8587605[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97276

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007517

muscle organ development

PMID:15634692[10]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97275

P

results_in_development_of:(EMAPA:17743)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007517

muscle organ development

PMID:8587605[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857219

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P13349

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001952

regulation of cell-matrix adhesion

PMID:16554364[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857973

P

  • regulates_o_has_participant:(EMAPA:16423)
  • regulates_o_has_participant:(CL:0000056)|regulates_o_has_participant:(EMAPA:16426)
  • regulates_o_has_participant:(CL:0000056)|regulates_o_has_participant:(EMAPA:16429)
  • regulates_o_has_participant:(CL:0000056)|regulates_o_has_participant:(EMAPA:16432)
  • regulates_o_has_participant:(CL:0000056)|regulates_o_has_participant:(EMAPA:16435)
  • regulates_o_has_participant:(CL:0000056)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001756

somitogenesis

PMID:8565825[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857219

P

has_participant:(EMAPA:16184)|has_participant:(EMAPA:16414)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001756

somitogenesis

PMID:19531352[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857973

P

has_participant:(EMAPA:16184)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001756

somitogenesis

PMID:10929709[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2449231

P

has_participant:(EMAPA:16184)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001503

ossification

PMID:8587605[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857219

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001502

cartilage condensation

PMID:8565825[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857219

P

occurs_in:(EMAPA:17397)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:24361185[12]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(MGI:MGI:1919580)

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P13349
ensembl:ENSP00000228644

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002546

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002546

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002546
InterPro:IPR039704

P

Seeded From UniProt

complete

involved_in

GO:0007517

muscle organ development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002546
InterPro:IPR039704

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011598
InterPro:IPR036638

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:1846704[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:1846704[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007517

muscle organ development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0517

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Sambasivan, R et al. (2009) Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev. Cell 16 810-21 PubMed GONUTS page
  3. 3.0 3.1 Kaul, A et al. (2000) Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Cell 102 17-9 PubMed GONUTS page
  4. 4.0 4.1 Yeung, F et al. (2012) Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. Nucleic Acids Res. 40 7303-18 PubMed GONUTS page
  5. Hawke, TJ et al. (2007) Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers. Am. J. Physiol., Cell Physiol. 293 C1636-44 PubMed GONUTS page
  6. Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page
  7. 7.0 7.1 Bajanca, F et al. (2006) Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo. Development 133 1635-44 PubMed GONUTS page
  8. Rudnicki, MA et al. (1993) MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75 1351-9 PubMed GONUTS page
  9. 9.0 9.1 9.2 Wang, Y et al. (1996) Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature 379 823-5 PubMed GONUTS page
  10. Brent, AE et al. (2005) Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132 515-28 PubMed GONUTS page
  11. 11.0 11.1 Grass, S et al. (1996) Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development 122 141-50 PubMed GONUTS page
  12. Bowlin, KM et al. () Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage. Differentiation 86 184-91 PubMed GONUTS page
  13. 13.0 13.1 Weintraub, H et al. (1991) The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251 761-6 PubMed GONUTS page