MOUSE:MBP

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mbp (synonyms: Shi)
Protein Name(s)	Myelin basic protein MBP Myelin A1 protein
External Links
UniProt	P04370
EMBL	M11533 M11291 M11529 M11530 M11531 M11532 M11533 M11291 M11529 M11530 M11531 L00404 L00398 L00400 L00401 L00402 L00404 L00398 L00399 L00400 L00401 L00402 L00404 L00398 L00400 L00401 L00402 L00403 L00404 L00398 L00399 L00400 L00401 L00402 L00403 M15060 M15062 X67319 L07507 L07508 L07509 L07505 L07504 AK005129 BC004704 M24410 M36275 K00989 M20010
CCDS	CCDS29373.1 CCDS29374.1 CCDS29376.1 CCDS29377.1 CCDS29378.1 CCDS29379.1 CCDS37875.1
PIR	A45421
RefSeq	NP_001020416.1 NP_001020422.1 NP_001020425.1 NP_001020426.1 NP_001020427.1 NP_001020429.1 NP_001020430.1 NP_034907.1
UniGene	Mm.252063 Mm.454459
PDB	2LUG
PDBsum	2LUG
DisProt	DP00237
ProteinModelPortal	P04370
SMR	P04370
BioGrid	201336
IntAct	P04370
MINT	MINT-4101448
ChEMBL	CHEMBL1764935
PhosphoSite	P04370
MaxQB	P04370
PaxDb	P04370
PRIDE	P04370
Ensembl	ENSMUST00000047865 ENSMUST00000062446 ENSMUST00000075372 ENSMUST00000080658 ENSMUST00000091789 ENSMUST00000102812 ENSMUST00000114674 ENSMUST00000143506
GeneID	17196
KEGG	mmu:17196
UCSC	uc008fts.1 uc008ftu.1 uc008ftv.1 uc008ftw.1 uc008fty.1 uc029tqh.1
CTD	4155
MGI	MGI:96925
eggNOG	NOG75180
GeneTree	ENSGT00390000014772
HOVERGEN	HBG008347
InParanoid	P04370
KO	K17269
OrthoDB	EOG7M0NRZ
PhylomeDB	P04370
TreeFam	TF333391
ChiTaRS	Mbp
NextBio	291554
PMAP-CutDB	P04370
PRO	PR:P04370
Proteomes	UP000000589
Bgee	P04370
CleanEx	MM_MBP
ExpressionAtlas	P04370
Genevestigator	P04370
GO	GO:0071944 GO:0042995 GO:0043218 GO:0005737 GO:0033269 GO:0043209 GO:0043025 GO:0005634 GO:0005886 GO:0002020 GO:0019911 GO:0007568 GO:0061024 GO:0042552 GO:0050771 GO:0070542 GO:0046689 GO:0032570 GO:0009636 GO:0034612 GO:0021762
InterPro	IPR000548
PANTHER	PTHR11429
Pfam	PF01669
PRINTS	PR00212
PROSITE	PS00569

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019911	structural constituent of myelin sheath	PMID:14614079^[1]	ECO:0000315			F		•Requires for normal myelin compaction (14614079). •Decrease the sciatic nerves of aged rats by increasing the number of myelin sheath lamellae. Fig.3	complete CACAO 9531
enables	GO:0005516	calmodulin binding	PMID:19855925^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DP25	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:19855925^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DP24	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:19855925^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DP23	F		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:19855925^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19855925^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:12372841^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q05910	F		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96925 PANTHER:PTN000152735	C		Seeded From UniProt	complete
part_of	GO:0043218	compact myelin	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96925 PANTHER:PTN000152735 RGD:3054	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96925 PANTHER:PTN000152735	C		Seeded From UniProt	complete
involved_in	GO:0042552	myelination	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96925 PANTHER:PTN000152735 RGD:3054	P		Seeded From UniProt	complete
part_of	GO:0033269	internode region of axon	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96925 PANTHER:PTN000152735	C		Seeded From UniProt	complete
enables	GO:0019911	structural constituent of myelin sheath	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000152735 RGD:3054	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904685	positive regulation of metalloendopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904209	positive regulation of chemokine (C-C motif) ligand 2 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:16723544^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061024	membrane organization	PMID:20334434^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0043218	compact myelin	PMID:12718855^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:24101522^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:20578039^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35253)	Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:1694232^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17577)	Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:16421295^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32678) part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:16405874^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:16421295^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:16421295^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042552	myelination	PMID:14614079^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035633	maintenance of permeability of blood-brain barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034115	negative regulation of heterotypic cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	P		Seeded From UniProt	complete
part_of	GO:0033269	internode region of axon	PMID:16421295^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32678) part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009636	response to toxic substance	PMID:20578039^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:17329413^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3708458	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02686	P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	P		Seeded From UniProt	complete
involved_in	GO:1904685	positive regulation of metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	P		Seeded From UniProt	complete
involved_in	GO:1904209	positive regulation of chemokine (C-C motif) ligand 2 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	P		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	C		Seeded From UniProt	complete
involved_in	GO:0035633	maintenance of permeability of blood-brain barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	P		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02686 ensembl:ENSP00000380958	P		Seeded From UniProt	complete
enables	GO:0019911	structural constituent of myelin sheath	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000548	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0176	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Farhadi, HF et al. (2003) A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. J. Neurosci. 23 10214-23 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Majava, V et al. (2010) Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Amino Acids 39 59-71 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ Schlomann, U et al. (2002) The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion. J. Biol. Chem. 277 48210-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kim, HJ et al. (2006) WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. J. Neurosci. 26 5849-59 PubMed GONUTS page
↑ Suresh, S et al. (2010) Myelin basic protein and myelin protein 2 act synergistically to cause stacking of lipid bilayers. Biochemistry 49 3456-63 PubMed GONUTS page
↑ Simonen, M et al. (2003) Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38 201-11 PubMed GONUTS page
↑ Lin, ST et al. (2013) MicroRNA-23a promotes myelination in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 110 17468-73 PubMed GONUTS page
↑ ^10.0 ^10.1 Parenti, R et al. (2010) Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia 58 1594-609 PubMed GONUTS page
↑ Griffiths, IR et al. (1990) Rumpshaker mouse: a new X-linked mutation affecting myelination: evidence for a defect in PLP expression. J. Neurocytol. 19 273-83 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Brockschnieder, D et al. (2006) Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. J. Neurosci. 26 757-62 PubMed GONUTS page
↑ Fukazawa, N et al. (2006) Identification and functional characterization of mouse TPO1 as a myelin membrane protein. Brain Res. 1070 1-14 PubMed GONUTS page
↑ Schwander, M et al. (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J. Neurosci. 27 2163-75 PubMed GONUTS page

[PMID:14614079-1] 1.0 ^1.1 Farhadi, HF et al. (2003) A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. J. Neurosci. 23 10214-23 PubMed GONUTS page

[PMID:19855925-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Majava, V et al. (2010) Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Amino Acids 39 59-71 PubMed GONUTS page

[PMID:17634366-3] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:12372841-4] Schlomann, U et al. (2002) The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion. J. Biol. Chem. 277 48210-9 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16723544-6] Kim, HJ et al. (2006) WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. J. Neurosci. 26 5849-59 PubMed GONUTS page

[PMID:20334434-7] Suresh, S et al. (2010) Myelin basic protein and myelin protein 2 act synergistically to cause stacking of lipid bilayers. Biochemistry 49 3456-63 PubMed GONUTS page

[PMID:12718855-8] Simonen, M et al. (2003) Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38 201-11 PubMed GONUTS page

[PMID:24101522-9] Lin, ST et al. (2013) MicroRNA-23a promotes myelination in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 110 17468-73 PubMed GONUTS page

[PMID:20578039-10] 10.0 ^10.1 Parenti, R et al. (2010) Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia 58 1594-609 PubMed GONUTS page

[PMID:1694232-11] Griffiths, IR et al. (1990) Rumpshaker mouse: a new X-linked mutation affecting myelination: evidence for a defect in PLP expression. J. Neurocytol. 19 273-83 PubMed GONUTS page

[PMID:16421295-12] 12.0 ^12.1 ^12.2 ^12.3 Brockschnieder, D et al. (2006) Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. J. Neurosci. 26 757-62 PubMed GONUTS page

[PMID:16405874-13] Fukazawa, N et al. (2006) Identification and functional characterization of mouse TPO1 as a myelin membrane protein. Brain Res. 1070 1-14 PubMed GONUTS page

[PMID:17329413-14] Schwander, M et al. (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J. Neurosci. 27 2163-75 PubMed GONUTS page

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MOUSE:MBP

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