MOUSE:MAG

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mag
Protein Name(s)	Myelin-associated glycoprotein Siglec-4a
External Links
UniProt	P20917
EMBL	M31811 M74793 M74783 M74784 M74785 M74786 M74787 M74788 M74790 M74791
CCDS	CCDS21115.1
PIR	B33785
RefSeq	NP_034888.1 XP_006539658.1
UniGene	Mm.241355
ProteinModelPortal	P20917
SMR	P20917
BioGrid	201285
IntAct	P20917
MINT	MINT-202735
BindingDB	P20917
ChEMBL	CHEMBL1250416
PhosphoSite	P20917
MaxQB	P20917
PaxDb	P20917
PRIDE	P20917
Ensembl	ENSMUST00000040548 ENSMUST00000187137
GeneID	17136
KEGG	mmu:17136
UCSC	uc009ghb.1
CTD	4099
MGI	MGI:96912
eggNOG	NOG290903
GeneTree	ENSGT00760000119139
HOGENOM	HOG000113464
HOVERGEN	HBG006317
InParanoid	P20917
KO	K06771
OMA	CQASFPN
OrthoDB	EOG7JDQX2
PhylomeDB	P20917
TreeFam	TF332441
Reactome	REACT_203657 REACT_211508
NextBio	291348
PRO	PR:P20917
Proteomes	UP000000589
Bgee	P20917
CleanEx	MM_MAG
ExpressionAtlas	P20917
Genevestigator	P20917
GO	GO:0016021 GO:0043209 GO:0033270 GO:0043220 GO:0030246 GO:0007155
Gene3D	2.60.40.10
InterPro	IPR013162 IPR007110 IPR013783 IPR013098 IPR003599 IPR003598
Pfam	PF08205 PF07679
SMART	SM00409 SM00408
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0031643	positive regulation of myelination	PMID:10625334^[1]	ECO:0000315			P		Fig 2b initiation of myelination is impaired in optic nerves of MAG-deficient mice	complete CACAO 9617
part_of	GO:0005887	integral component of plasma membrane	PMID:9482783^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0022010	central nervous system myelination	PMID:9482783^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:27922006^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20917	F		Seeded From UniProt	complete
enables	GO:0033691	sialic acid binding	PMID:27922006^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1905576	ganglioside GT1b binding	PMID:27922006^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:27922006^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:26335717^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07722	P		Seeded From UniProt	complete
involved_in	GO:0030517	negative regulation of axon extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07722	P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07722	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07722	P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:17640868^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20916	C		Seeded From UniProt	complete
involved_in	GO:0031643	positive regulation of myelination	PMID:10625334^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0043220	Schmidt-Lanterman incisure	PMID:12975355^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033270	paranode region of axon	PMID:12975355^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1905576	ganglioside GT1b binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	P		Seeded From UniProt	complete
part_of	GO:0097453	mesaxon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048711	positive regulation of astrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	P		Seeded From UniProt	complete
part_of	GO:0043220	Schmidt-Lanterman incisure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	C		Seeded From UniProt	complete
part_of	GO:0043218	compact myelin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20916	C		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:24101522^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:11283023^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20916	C		Seeded From UniProt	complete
part_of	GO:0035749	myelin sheath adaxonal region	PMID:12718855^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035749	myelin sheath adaxonal region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	C		Seeded From UniProt	complete
enables	GO:0033691	sialic acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	F		Seeded From UniProt	complete
part_of	GO:0033270	paranode region of axon	PMID:27583434^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031103	axon regeneration	PMID:20731761^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1328321	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030517	negative regulation of axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:20071523^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857216	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20916	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3035	F		Seeded From UniProt	complete
enables	GO:1905576	ganglioside GT1b binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	F		Seeded From UniProt	complete
involved_in	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	P		Seeded From UniProt	complete
part_of	GO:0097453	mesaxon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	C		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	P		Seeded From UniProt	complete
involved_in	GO:0048711	positive regulation of astrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	P		Seeded From UniProt	complete
part_of	GO:0043220	Schmidt-Lanterman incisure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	C		Seeded From UniProt	complete
part_of	GO:0035749	myelin sheath adaxonal region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	C		Seeded From UniProt	complete
enables	GO:0033691	sialic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	F		Seeded From UniProt	complete
involved_in	GO:0030517	negative regulation of axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07722 ensembl:ENSRNOP00000028544	F		Seeded From UniProt	complete
part_of	GO:0043218	compact myelin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20916 ensembl:ENSP00000376048	C		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20916 ensembl:ENSP00000376048	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20916 ensembl:ENSP00000376048	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Schachner, M & Bartsch, U (2000) Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin. Glia 29 154-65 PubMed GONUTS page
↑ ^2.0 ^2.1 Fujita, N et al. (1998) The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination. J. Neurosci. 18 1970-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Pronker, MF et al. (2016) Structural basis of myelin-associated glycoprotein adhesion and signalling. Nat Commun 7 13584 PubMed GONUTS page
↑ Palandri, A et al. (2015) Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways. Cell Death Dis 6 e1876 PubMed GONUTS page
↑ Mehta, NR et al. (2007) Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells. J. Biol. Chem. 282 27875-86 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^7.0 ^7.1 Traka, M et al. (2003) Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J. Cell Biol. 162 1161-72 PubMed GONUTS page
↑ Lin, ST et al. (2013) MicroRNA-23a promotes myelination in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 110 17468-73 PubMed GONUTS page
↑ Kleene, R et al. (2001) The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J. Biol. Chem. 276 21656-63 PubMed GONUTS page
↑ Simonen, M et al. (2003) Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38 201-11 PubMed GONUTS page
↑ Hu, B et al. (2016) Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. PLoS Genet. 12 e1006290 PubMed GONUTS page
↑ Khazaei, MR et al. (2010) Bex1 is involved in the regeneration of axons after injury. J. Neurochem. 115 910-20 PubMed GONUTS page
↑ Bai, Y et al. (2010) Conduction block in PMP22 deficiency. J. Neurosci. 30 600-8 PubMed GONUTS page

[PMID:10625334-1] 1.0 ^1.1 Schachner, M & Bartsch, U (2000) Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin. Glia 29 154-65 PubMed GONUTS page

[PMID:9482783-2] 2.0 ^2.1 Fujita, N et al. (1998) The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination. J. Neurosci. 18 1970-8 PubMed GONUTS page

[PMID:27922006-3] 3.0 ^3.1 ^3.2 ^3.3 Pronker, MF et al. (2016) Structural basis of myelin-associated glycoprotein adhesion and signalling. Nat Commun 7 13584 PubMed GONUTS page

[PMID:26335717-4] Palandri, A et al. (2015) Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways. Cell Death Dis 6 e1876 PubMed GONUTS page

[PMID:17640868-5] Mehta, NR et al. (2007) Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells. J. Biol. Chem. 282 27875-86 PubMed GONUTS page

[PMID:17634366-6] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:12975355-7] 7.0 ^7.1 Traka, M et al. (2003) Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J. Cell Biol. 162 1161-72 PubMed GONUTS page

[PMID:24101522-8] Lin, ST et al. (2013) MicroRNA-23a promotes myelination in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 110 17468-73 PubMed GONUTS page

[PMID:11283023-9] Kleene, R et al. (2001) The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J. Biol. Chem. 276 21656-63 PubMed GONUTS page

[PMID:12718855-10] Simonen, M et al. (2003) Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38 201-11 PubMed GONUTS page

[PMID:27583434-11] Hu, B et al. (2016) Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. PLoS Genet. 12 e1006290 PubMed GONUTS page

[PMID:20731761-12] Khazaei, MR et al. (2010) Bex1 is involved in the regeneration of axons after injury. J. Neurochem. 115 910-20 PubMed GONUTS page

[PMID:20071523-13] Bai, Y et al. (2010) Conduction block in PMP22 deficiency. J. Neurosci. 30 600-8 PubMed GONUTS page

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MOUSE:MAG

Contents

Annotations

Notes

References

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