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MOUSE:LBH

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Lbh
Protein Name(s) Protein LBH

Limb bud and heart-expressed protein

External Links
UniProt Q9CX60
EMBL AF317517
AK020110
BC026827
BC052470
CCDS CCDS28964.1
RefSeq NP_084275.3
UniGene Mm.154109
DisProt DP00661
PhosphoSite Q9CX60
MaxQB Q9CX60
PaxDb Q9CX60
PRIDE Q9CX60
Ensembl ENSMUST00000024857
GeneID 77889
KEGG mmu:77889
UCSC uc008dng.2
CTD 81606
MGI MGI:1925139
eggNOG NOG39814
GeneTree ENSGT00390000009189
HOGENOM HOG000074061
HOVERGEN HBG105431
InParanoid Q9CX60
OMA FDRYCKL
OrthoDB EOG7TQV35
PhylomeDB Q9CX60
TreeFam TF332770
NextBio 347755
PRO PR:Q9CX60
Proteomes UP000000589
Bgee Q9CX60
CleanEx MM_LBH
Genevestigator Q9CX60
GO GO:0005737
GO:0005634
GO:0007275
GO:0045893
GO:0030193
GO:0006351
InterPro IPR013294
PIRSF PIRSF008130
PRINTS PR01881

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:11336496[1]

ECO:0000314

C

Section of the text labeled "Biochemical Characterization of Lbh protein" refers to N and C terminus labeling using an antibody to detect localization of the Lbh protein in the nucleus. (figure 2b)

complete
CACAO 3682

part_of

GO:0032991

protein-containing complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q53QV2

C

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q53QV2

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q53QV2

C

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q53QV2

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11336496[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

PMID:25655704[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033147

negative regulation of intracellular estrogen receptor signaling pathway

PMID:25655704[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904674

positive regulation of somatic stem cell population maintenance

PMID:25655704[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000737

negative regulation of stem cell differentiation

PMID:25655704[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904677

positive regulation of somatic stem cell division

PMID:25655704[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060644

mammary gland epithelial cell differentiation

PMID:25655704[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000103

positive regulation of mammary stem cell proliferation

PMID:25655704[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030879

mammary gland development

PMID:25655704[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:25655704[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:11336496[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q53QV2

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q53QV2

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043408

regulation of MAPK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q53QV2

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q53QV2

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q53QV2

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11336496[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q53QV2

C

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53QV2
ensembl:ENSP00000378733

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53QV2
ensembl:ENSP00000378733

P

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53QV2
ensembl:ENSP00000378733

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53QV2
ensembl:ENSP00000378733

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53QV2
ensembl:ENSP00000378733

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53QV2
ensembl:ENSP00000378733

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013294

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Briegel, KJ & Joyner, AL (2001) Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development. Dev. Biol. 233 291-304 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Lindley, LE et al. (2015) The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage. Development 142 893-904 PubMed GONUTS page