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MOUSE:KCNH1
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Kcnh1 (synonyms: Eag) | |
Protein Name(s) | Potassium voltage-gated channel subfamily H member 1
Ether-a-go-go potassium channel 1 EAG channel 1 EAG1 m-eag Voltage-gated potassium channel subunit Kv10.1 | |
External Links | ||
UniProt | Q60603 | |
EMBL | U04294 | |
CCDS | CCDS15627.1 | |
PIR | I48912 | |
RefSeq | NP_034730.1 | |
UniGene | Mm.4489 | |
PDB | 4F8A 4HOI 4LLO | |
PDBsum | 4F8A 4HOI 4LLO | |
ProteinModelPortal | Q60603 | |
SMR | Q60603 | |
IntAct | Q60603 | |
PhosphoSite | Q60603 | |
PaxDb | Q60603 | |
PRIDE | Q60603 | |
Ensembl | ENSMUST00000078470 | |
GeneID | 16510 | |
KEGG | mmu:16510 | |
UCSC | uc007edo.1 | |
CTD | 3756 | |
MGI | MGI:1341721 | |
eggNOG | COG2202 | |
GeneTree | ENSGT00760000118772 | |
HOGENOM | HOG000230794 | |
HOVERGEN | HBG101348 | |
InParanoid | Q60603 | |
KO | K04904 | |
OMA | HAKLHAP | |
OrthoDB | EOG7QG43V | |
PhylomeDB | Q60603 | |
TreeFam | TF313130 | |
Reactome | REACT_199077 | |
NextBio | 289847 | |
PRO | PR:Q60603 | |
Proteomes | UP000000589 | |
Bgee | Q60603 | |
ExpressionAtlas | Q60603 | |
Genevestigator | Q60603 | |
GO | GO:0005887 GO:0005637 GO:0000155 GO:0005249 GO:0071805 GO:0042391 | |
Gene3D | 2.60.120.10 | |
InterPro | IPR018490 IPR000595 IPR030170 IPR005821 IPR003949 IPR003938 IPR001610 IPR000014 IPR000700 IPR014710 | |
PANTHER | PTHR10217:SF377 | |
Pfam | PF00027 PF00520 PF13426 | |
PRINTS | PR01463 PR01464 | |
SMART | SM00100 SM00086 SM00091 | |
SUPFAM | SSF51206 SSF55785 | |
TIGRFAMs | TIGR00229 | |
PROSITE | PS50042 PS50113 PS50112 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:1902936 |
phosphatidylinositol bisphosphate binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071277 |
cellular response to calcium ion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048015 |
phosphatidylinositol-mediated signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
NOT|enables |
GO:0030551 |
cyclic nucleotide binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031901 |
early endosome membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0006063 |
over expression analysis evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0006039 |
genetically encoded fluorescent electrophysiology assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0001225 |
knockout evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0006063 |
over expression analysis evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0006039 |
genetically encoded fluorescent electrophysiology assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0001225 |
knockout evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
enables |
GO:0099508 |
voltage-gated ion channel activity involved in regulation of presynaptic membrane potential |
ECO:0006063 |
over expression analysis evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:0099508 |
voltage-gated ion channel activity involved in regulation of presynaptic membrane potential |
ECO:0006039 |
genetically encoded fluorescent electrophysiology assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:0099508 |
voltage-gated ion channel activity involved in regulation of presynaptic membrane potential |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:0099508 |
voltage-gated ion channel activity involved in regulation of presynaptic membrane potential |
ECO:0001225 |
knockout evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0098688 |
parallel fiber to Purkinje cell synapse |
ECO:0006063 |
over expression analysis evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0098688 |
parallel fiber to Purkinje cell synapse |
ECO:0006039 |
genetically encoded fluorescent electrophysiology assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0098688 |
parallel fiber to Purkinje cell synapse |
ECO:0006013 |
patch-clamp recording evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0098688 |
parallel fiber to Purkinje cell synapse |
ECO:0001225 |
knockout evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1341721 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042391 |
regulation of membrane potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1341722 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1341721 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000535 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:1902936 |
phosphatidylinositol bisphosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0099056 |
integral component of presynaptic membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0071889 |
14-3-3 protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0071277 |
cellular response to calcium ion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071277 |
cellular response to calcium ion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048015 |
phosphatidylinositol-mediated signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0045202 |
synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0044325 |
ion channel binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0042734 |
presynaptic membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0034705 |
potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0034220 |
ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031901 |
early endosome membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030673 |
axolemma |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005637 |
nuclear inner membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005516 |
calmodulin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001964 |
startle response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:68398 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0099505 |
regulation of presynaptic membrane potential |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0099508 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0099505 |
regulation of presynaptic membrane potential |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0099508 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0099505 |
regulation of presynaptic membrane potential |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0099508 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0099505 |
regulation of presynaptic membrane potential |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0099508 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005516 |
calmodulin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005267 |
potassium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005637 |
nuclear inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030425 |
dendrite |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0042734 |
presynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031901 |
early endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043204 |
perikaryon |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030424 |
axon |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Brelidze, TI et al. (2009) Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods. J. Biol. Chem. 284 27989-97 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 Mortensen, LS et al. (2015) KV 10.1 opposes activity-dependent increase in Ca²⁺ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse. J. Physiol. (Lond.) 593 181-96 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
e
g
i
m
p
- GO:0098688 ! parallel fiber to Purkinje cell synapse
- GO:0043204 ! perikaryon
- GO:0048471 ! perinuclear region of cytoplasm
- GO:1902936 ! phosphatidylinositol bisphosphate binding
- GO:0048015 ! phosphatidylinositol-mediated signaling
- GO:0005886 ! plasma membrane
- GO:0045211 ! postsynaptic membrane
- GO:0014069 ! postsynaptic density
- GO:0005267 ! potassium channel activity
- GO:0034705 ! potassium channel complex
- GO:0006813 ! potassium ion transport
- GO:0071805 ! potassium ion transmembrane transport
- GO:0042734 ! presynaptic membrane
- GO:0046982 ! protein heterodimerization activity
- GO:0019901 ! protein kinase binding
r
- GO:0042391 ! regulation of membrane potential
- GO:0042127 ! regulation of cell population proliferation
- GO:2000300 ! regulation of synaptic vesicle exocytosis
- GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
- GO:0034765 ! regulation of monoatomic ion transmembrane transport
- GO:0099505 ! regulation of presynaptic membrane potential
- Rodentia