MOUSE:KCC2A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Camk2a
Protein Name(s)	Calcium/calmodulin-dependent protein kinase type II subunit alpha CaM kinase II subunit alpha CaMK-II subunit alpha
External Links
UniProt	P11798
EMBL	X14836 X87142 AK083245 BC031745
CCDS	CCDS29276.1 CCDS29277.1
PIR	JC6083 S04365
RefSeq	NP_001273738.1 NP_033922.1 NP_803126.1
UniGene	Mm.131530 Mm.446530
PDB	1HKX
PDBsum	1HKX
ProteinModelPortal	P11798
SMR	P11798
BioGrid	198461
DIP	DIP-31593N
IntAct	P11798
MINT	MINT-136541
BindingDB	P11798
GuidetoPHARMACOLOGY	1555
PhosphoSite	P11798
MaxQB	P11798
PaxDb	P11798
PRIDE	P11798
Ensembl	ENSMUST00000102888 ENSMUST00000115295
GeneID	12322
KEGG	mmu:12322
UCSC	uc008fbg.2 uc008fbh.2
CTD	815
MGI	MGI:88256
eggNOG	COG0515
GeneTree	ENSGT00760000118944
HOGENOM	HOG000233016
HOVERGEN	HBG108055
InParanoid	P11798
KO	K04515
OrthoDB	EOG7ZD1VM
TreeFam	TF315229
BRENDA	2.7.11.17
Reactome	REACT_198244 REACT_198246 REACT_198248 REACT_198660 REACT_213550 REACT_221970 REACT_258217
ChiTaRS	Camk2a
EvolutionaryTrace	P11798
NextBio	280898
PRO	PR:P11798
Proteomes	UP000000589
Bgee	P11798
ExpressionAtlas	P11798
Genevestigator	P11798
GO	GO:0030054 GO:0005739 GO:0097481 GO:0005634 GO:0042734 GO:0005524 GO:0004683 GO:0035254 GO:0004674 GO:0006816 GO:0000082 GO:0018105 GO:0051928 GO:0010666 GO:0051092 GO:0046777 GO:1902108 GO:0048168 GO:0046928 GO:0002931
InterPro	IPR020636 IPR013543 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24347
Pfam	PF08332 PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2001222	regulation of neuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQM7	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23051746^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:15994560^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0009931	calcium-dependent protein serine/threonine kinase activity	PMID:15994560^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:15994560^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:15994560^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1990443	peptidyl-threonine autophosphorylation	PMID:28130356^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQM7	C		Seeded From UniProt	complete
part_of	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQM7	C		Seeded From UniProt	complete
involved_in	GO:0060996	dendritic spine development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UQM7	P		Seeded From UniProt	complete
involved_in	GO:0099148	regulation of synaptic vesicle docking	PMID:17660813^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099148	regulation of synaptic vesicle docking	PMID:17660813^[4]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:17660813^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:17660813^[4]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002389359 WB:WBGene00006779	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341265 PANTHER:PTN002389359 RGD:2263	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88256 PANTHER:PTN002389359 UniProtKB:Q13557 UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264607 MGI:MGI:88256 MGI:MGI:88257 PANTHER:PTN002389359 RGD:2261 RGD:2262 RGD:2263 RGD:621802 UniProtKB:Q13557 UniProtKB:Q9UQM7 WB:WBGene00006779	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001222	regulation of neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990443	peptidyl-threonine autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903076	regulation of protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	PMID:23051746^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099573	glutamatergic postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
part_of	GO:0099523	presynaptic cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099004	calmodulin dependent kinase signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098989	NMDA selective glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098970	postsynaptic neurotransmitter receptor diffusion trapping	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060996	dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051928	positive regulation of calcium ion transport	PMID:23051746^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0005739) occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:25297099^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048168	regulation of neuronal synaptic plasticity	PMID:17610578^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32845) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046928	regulation of neurotransmitter secretion	PMID:12629219^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2655688	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:12660151^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038166	angiotensin-activated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	P		Seeded From UniProt	complete
enables	GO:0035254	glutamate receptor binding	PMID:16710293^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01097	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
enables	GO:0032794	GTPase activating protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:23051746^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16105) has_direct_input:(MGI:MGI:3026965)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17114649^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	PMID:23051746^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0009931	calcium-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:12660151^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	P		Seeded From UniProt	complete
part_of	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2261	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:23051746^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(MGI:MGI:3026965) occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12660151^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18480293^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1347359)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002931	response to ischemia	PMID:23051746^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000082	G1/S transition of mitotic cell cycle	PMID:12660151^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099634	postsynaptic specialization membrane	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098970	C		Seeded From UniProt	complete
involved_in	GO:2001222	regulation of neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	P		Seeded From UniProt	complete
involved_in	GO:1990443	peptidyl-threonine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	P		Seeded From UniProt	complete
involved_in	GO:0060996	dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	F		Seeded From UniProt	complete
involved_in	GO:0038166	angiotensin-activated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	F		Seeded From UniProt	complete
enables	GO:0009931	calcium-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	P		Seeded From UniProt	complete
part_of	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UQM7 ensembl:ENSP00000381412	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039071	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543 InterPro:IPR039071	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR013543	P		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.17	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Joiner, ML et al. (2012) CaMKII determines mitochondrial stress responses in heart. Nature 491 269-73 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Pufall, MA et al. (2005) Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science 309 142-5 PubMed GONUTS page
↑ Stephenson, JR et al. (2017) A Novel Human Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J. Neurosci. 37 2216-2233 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Hojjati, MR et al. (2007) Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nat. Neurosci. 10 1125-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Jia, JM et al. (2014) The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. J. Neurosci. 34 13725-36 PubMed GONUTS page
↑ Liu, S et al. (2007) Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. Eur. J. Neurosci. 25 3583-96 PubMed GONUTS page
↑ Hinds, HL et al. (2003) Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proc. Natl. Acad. Sci. U.S.A. 100 4275-80 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Afroze, T et al. (2003) Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. Am. J. Physiol., Cell Physiol. 285 C88-95 PubMed GONUTS page
↑ Nakazawa, T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 25 2867-77 PubMed GONUTS page
↑ Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page
↑ Mizutani, A et al. (2008) Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. J. Neurosci. 28 5369-82 PubMed GONUTS page

[PMID:23051746-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Joiner, ML et al. (2012) CaMKII determines mitochondrial stress responses in heart. Nature 491 269-73 PubMed GONUTS page

[PMID:15994560-2] 2.0 ^2.1 ^2.2 ^2.3 Pufall, MA et al. (2005) Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science 309 142-5 PubMed GONUTS page

[PMID:28130356-3] Stephenson, JR et al. (2017) A Novel Human Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J. Neurosci. 37 2216-2233 PubMed GONUTS page

[PMID:17660813-4] 4.0 ^4.1 ^4.2 ^4.3 Hojjati, MR et al. (2007) Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nat. Neurosci. 10 1125-7 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25297099-6] Jia, JM et al. (2014) The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. J. Neurosci. 34 13725-36 PubMed GONUTS page

[PMID:17610578-7] Liu, S et al. (2007) Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. Eur. J. Neurosci. 25 3583-96 PubMed GONUTS page

[PMID:12629219-8] Hinds, HL et al. (2003) Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proc. Natl. Acad. Sci. U.S.A. 100 4275-80 PubMed GONUTS page

[PMID:12660151-9] 9.0 ^9.1 ^9.2 ^9.3 Afroze, T et al. (2003) Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. Am. J. Physiol., Cell Physiol. 285 C88-95 PubMed GONUTS page

[PMID:16710293-10] Nakazawa, T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 25 2867-77 PubMed GONUTS page

[PMID:17114649-11] Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page

[PMID:18480293-12] Mizutani, A et al. (2008) Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. J. Neurosci. 28 5369-82 PubMed GONUTS page

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