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MOUSE:K1C19

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Krt19 (synonyms: Krt1-19)
Protein Name(s) Keratin, type I cytoskeletal 19

Cytokeratin-19 CK-19 Keratin-19 K19

External Links
UniProt P19001
EMBL M28698
M36120
BC034561
BC085304
CCDS CCDS25411.1
PIR JQ0028
RefSeq NP_032497.1
UniGene Mm.439699
ProteinModelPortal P19001
SMR P19001
BioGrid 201024
IntAct P19001
MINT MINT-1859116
PhosphoSite P19001
MaxQB P19001
PaxDb P19001
PRIDE P19001
Ensembl ENSMUST00000007317
GeneID 16669
KEGG mmu:16669
UCSC uc007lkm.2
CTD 3880
MGI MGI:96693
eggNOG NOG148784
GeneTree ENSGT00760000118808
HOGENOM HOG000230975
HOVERGEN HBG013015
InParanoid P19001
KO K07604
OMA GQEDHYN
OrthoDB EOG7FV3Q8
PhylomeDB P19001
TreeFam TF332742
ChiTaRS Krt19
NextBio 290391
PRO PR:P19001
Proteomes UP000000589
Bgee P19001
CleanEx MM_KRT19
ExpressionAtlas P19001
Genevestigator P19001
GO GO:0071944
GO:0043034
GO:0016010
GO:0070062
GO:0005882
GO:0042383
GO:0030018
GO:0008307
GO:0060706
GO:0043627
GO:0045214
InterPro IPR001664
IPR018039
IPR002957
IPR009053
PANTHER PTHR23239
Pfam PF00038
PRINTS PR01248
SUPFAM SSF46579
PROSITE PS00226

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0048312

intracellular distribution of mitochondria

PMID:21209367[1]

ECO:0000315

P

Figure 2 G

complete

part_of

GO:0016327

apicolateral plasma membrane

PMID:25232867[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990357

terminal web

PMID:19321664[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000584)

Seeded From UniProt

complete

part_of

GO:0071944

cell periphery

PMID:19185580[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P08727

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060706

cell differentiation involved in embryonic placenta development

PMID:11062258[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96705

P

occurs_in:(EMAPA:16042)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045214

sarcomere organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P08727

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619936

F

Seeded From UniProt

complete

part_of

GO:0043034

costamere

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P08727

C

Seeded From UniProt

complete

part_of

GO:0042383

sarcolemma

PMID:15247274[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000746)

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

PMID:15247274[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000746)

Seeded From UniProt

complete

part_of

GO:0016010

dystrophin-associated glycoprotein complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:619936

C

Seeded From UniProt

complete

enables

GO:0008307

structural constituent of muscle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P08727

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007219

Notch signaling pathway

PMID:25446530[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P08727

C

Seeded From UniProt

complete

part_of

GO:0071944

cell periphery

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08727
ensembl:ENSP00000355124

C

Seeded From UniProt

complete

involved_in

GO:0045214

sarcomere organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08727
ensembl:ENSP00000355124

P

Seeded From UniProt

complete

involved_in

GO:0043627

response to estrogen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08727
ensembl:ENSP00000355124

P

Seeded From UniProt

complete

part_of

GO:0043034

costamere

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08727
ensembl:ENSP00000355124

C

Seeded From UniProt

complete

enables

GO:0008307

structural constituent of muscle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08727
ensembl:ENSP00000355124

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08727
ensembl:ENSP00000355124

C

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63279
ensembl:ENSRNOP00000019133

F

Seeded From UniProt

complete

part_of

GO:0016010

dystrophin-associated glycoprotein complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63279
ensembl:ENSRNOP00000019133

C

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664
InterPro:IPR002957

F

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0416
UniProtKB-KW:KW-0403

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lovering, RM et al. (2011) Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments. Am. J. Physiol., Cell Physiol. 300 C803-13 PubMed GONUTS page
  2. Wögenstein, KL et al. (2014) Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules. PLoS ONE 9 e108323 PubMed GONUTS page
  3. Grimm-Günter, EM et al. (2009) Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Mol. Biol. Cell 20 2549-62 PubMed GONUTS page
  4. Hand, NJ et al. (2009) The microRNA-30 family is required for vertebrate hepatobiliary development. Gastroenterology 136 1081-90 PubMed GONUTS page
  5. Tamai, Y et al. (2000) Cytokeratins 8 and 19 in the mouse placental development. J. Cell Biol. 151 563-72 PubMed GONUTS page
  6. 6.0 6.1 Ursitti, JA et al. (2004) Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex. J. Biol. Chem. 279 41830-8 PubMed GONUTS page
  7. Falix, FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev. Biol. 396 201-13 PubMed GONUTS page