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MOUSE:IRAK3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Irak3 (ECO:0000312 with MGI:MGI:1921164)
Protein Name(s) Interleukin-1 receptor-associated kinase 3

IRAK-3 IL-1 receptor-associated kinase M IRAK-M

External Links
UniProt Q8K4B2
EMBL AF461763
AJ440757
AK029057
AK049210
CCDS CCDS24204.1
RefSeq NP_082955.2
UniGene Mm.146194
ProteinModelPortal Q8K4B2
SMR Q8K4B2
BioGrid 216351
IntAct Q8K4B2
STRING 10090.ENSMUSP00000020448
iPTMnet Q8K4B2
PhosphoSitePlus Q8K4B2
MaxQB Q8K4B2
PaxDb Q8K4B2
PRIDE Q8K4B2
Ensembl ENSMUST00000020448
GeneID 73914
KEGG mmu:73914
UCSC uc007het.1
CTD 11213
MGI MGI:1921164
eggNOG KOG1187
COG0515
GeneTree ENSGT00530000063073
HOGENOM HOG000060319
HOVERGEN HBG052146
InParanoid Q8K4B2
KO K04732
OMA KLTDFAM
OrthoDB EOG091G0YKT
PhylomeDB Q8K4B2
TreeFam TF328924
Reactome [www.reactome.org/content/detail/R-MMU-446652 R-MMU-446652]
PRO PR:Q8K4B2
Proteomes UP000000589
Bgee ENSMUSG00000020227
CleanEx MM_IRAK3
ExpressionAtlas Q8K4B2
Genevisible Q8K4B2
GO GO:0005737
GO:0005634
GO:0005524
GO:0000287
GO:0046982
GO:0042803
GO:0004672
GO:0004674
GO:0019221
GO:0070498
GO:0002755
GO:0001960
GO:0045824
GO:0032695
GO:0032715
GO:0010936
GO:0043407
GO:0032088
GO:0042177
GO:0043242
GO:0034122
GO:0032720
GO:0010933
GO:0051092
GO:0046777
GO:0006468
GO:0043244
GO:0043330
GO:0070555
GO:0032496
GO:0032494
GO:0009615
Gene3D 1.10.533.10
InterPro IPR011029
IPR000488
IPR033610
IPR011009
IPR000719
PANTHER PTHR24419:SF24
Pfam PF00531
PF00069
SMART SM00005
SUPFAM SSF47986
SSF56112
PROSITE PS50017
PS50011

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006468

protein phosphorylation

PMID:27939424[1]

ECO:0000314

P

Provides phosphorylation inhibition.

complete
CACAO 12848

involved_in

GO:0045824

negative regulation of innate immune response

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043407

negative regulation of MAP kinase activity

PMID:17379480[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043330

response to exogenous dsRNA

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042177

negative regulation of protein catabolic process

PMID:17379480[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034122

negative regulation of toll-like receptor signaling pathway

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032720

negative regulation of tumor necrosis factor production

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032715

negative regulation of interleukin-6 production

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032695

negative regulation of interleukin-12 production

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032494

response to peptidoglycan

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010936

negative regulation of macrophage cytokine production

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010933

positive regulation of macrophage tolerance induction

PMID:12150927[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:12150927[2]

ECO:0000305

curator inference used in manual assertion

GO:0043330

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:17379480[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17379480[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001960

negative regulation of cytokine-mediated signaling pathway

PMID:12150927[2]

ECO:0000305

curator inference used in manual assertion

GO:0032715

P

Seeded From UniProt

complete

involved_in

GO:0043244

regulation of protein complex disassembly

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107420
MGI:MGI:1921164
PANTHER:PTN001563216
UniProtKB:O43187
UniProtKB:P51617
UniProtKB:Q9Y616

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107420
MGI:MGI:1921164
MGI:MGI:2429603
PANTHER:PTN001563216
UniProtKB:O43187
UniProtKB:P51617
UniProtKB:Q9Y616

P

Seeded From UniProt

complete

involved_in

GO:0043407

negative regulation of MAP kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921164
PANTHER:PTN002815516
UniProtKB:Q9Y616

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1194498
PANTHER:PTN000784925
UniProtKB:Q8TF76

P

Seeded From UniProt

complete

involved_in

GO:0032720

negative regulation of tumor necrosis factor production

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921164
PANTHER:PTN002815516
UniProtKB:Q9Y616

P

Seeded From UniProt

complete

involved_in

GO:0032695

negative regulation of interleukin-12 production

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921164
PANTHER:PTN002815516
UniProtKB:Q9Y616

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107420
MGI:MGI:1921164
MGI:MGI:2182474
PANTHER:PTN000701353
RGD:1305303
RGD:1563841

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003882
PANTHER:PTN000701353

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003882
FB:FBgn0010441
MGI:MGI:1921164
PANTHER:PTN000784925
TAIR:locus:2012340
UniProtKB:Q9Y616

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1194498
MGI:MGI:1921164
PANTHER:PTN000784925
TAIR:locus:2012340
UniProtKB:P51617
UniProtKB:Q8TF76
UniProtKB:Q9Y616

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1194498
MGI:MGI:1921164
PANTHER:PTN000784925
UniProtKB:P51617
UniProtKB:Q9NWZ3
UniProtKB:Q9Y616

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070555

response to interleukin-1

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070498

interleukin-1-mediated signaling pathway

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070498

interleukin-1-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046777

protein autophosphorylation

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043407

negative regulation of MAP kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043242

negative regulation of protein complex disassembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042981

regulation of apoptotic process

PMID:12819136[6]

ECO:0000245

automatically integrated combinatorial evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042177

negative regulation of protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032720

negative regulation of tumor necrosis factor production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032715

negative regulation of interleukin-6 production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032695

negative regulation of interleukin-12 production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:12819136[6]

ECO:0000245

automatically integrated combinatorial evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:12054681[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9Y616

F

Seeded From UniProt

complete

involved_in

GO:0070555

response to interleukin-1

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

involved_in

GO:0070498

interleukin-1-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

F

Seeded From UniProt

complete

involved_in

GO:0043407

negative regulation of MAP kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

involved_in

GO:0043242

negative regulation of protein complex disassembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

F

Seeded From UniProt

complete

involved_in

GO:0042177

negative regulation of protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

involved_in

GO:0032720

negative regulation of tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

involved_in

GO:0032715

negative regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

involved_in

GO:0032695

negative regulation of interleukin-12 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Y616
ensembl:ENSP00000261233

F

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033610

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000488

P

Seeded From UniProt

complete

involved_in

GO:0034122

negative regulation of toll-like receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033610

P

Seeded From UniProt

complete

involved_in

GO:0045824

negative regulation of innate immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033610

P

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Rothschild, DE et al. (2017) Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M. EBioMedicine 15 36-47 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Kobayashi, K et al. (2002) IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110 191-202 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Su, J et al. (2007) Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling. Cell. Signal. 19 1596-601 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Rosati, O & Martin, MU (2002) Identification and characterization of murine IRAK-M. Biochem. Biophys. Res. Commun. 293 1472-7 PubMed GONUTS page
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. 6.0 6.1 Reed, JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 13 1376-88 PubMed GONUTS page