MOUSE:ILK

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ilk
Protein Name(s)	Integrin-linked protein kinase
External Links
UniProt	O55222
EMBL	U94479 BC003737
CCDS	CCDS21659.1
RefSeq	NP_001155196.1 NP_034692.2
UniGene	Mm.274846
ProteinModelPortal	O55222
SMR	O55222
BioGrid	200649
DIP	DIP-41971N
IntAct	O55222
MINT	MINT-150552
STRING	10090.ENSMUSP00000033182
PhosphoSite	O55222
MaxQB	O55222
PaxDb	O55222
PRIDE	O55222
Ensembl	ENSMUST00000033182 ENSMUST00000163389
GeneID	16202
KEGG	mmu:16202
UCSC	uc009izb.2
CTD	3611
MGI	MGI:1195267
eggNOG	COG0666
GeneTree	ENSGT00760000118807
HOGENOM	HOG000047828
HOVERGEN	HBG002437
InParanoid	O55222
KO	K06272
OMA	ARINENQ
OrthoDB	EOG7T1RB0
PhylomeDB	O55222
TreeFam	TF315194
BRENDA	2.7.10.2
Reactome	REACT_242946
NextBio	289147
PRO	PR:O55222
Proteomes	UP000000589
Bgee	O55222
CleanEx	MM_ILK
ExpressionAtlas	O55222
Genevestigator	O55222
GO	GO:0005911 GO:0043034 GO:0043198 GO:0005925 GO:0030027 GO:0043025 GO:0005634 GO:0005886 GO:0043234 GO:0030017 GO:0001725 GO:0043195 GO:0005524 GO:0004674 GO:0004871 GO:0001658 GO:0007569 GO:0007050 GO:0030030 GO:0045197 GO:0043206 GO:0010761 GO:0007229 GO:0032288 GO:0022011 GO:0010667 GO:2000178 GO:0043524 GO:0006469 GO:0014912 GO:0048662 GO:0021675 GO:0048812 GO:0018105 GO:0045773 GO:0030513 GO:0090263 GO:0030335 GO:0008284 GO:0001954 GO:0050775 GO:0043406 GO:0045663 GO:0045669 GO:0051897 GO:0045893 GO:0051291 GO:0043491 GO:0032956 GO:0014044 GO:0034446
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR016253 IPR011009 IPR000719 IPR001245
Pfam	PF00023 PF07714
PIRSF	PIRSF000654
SMART	SM00248
SUPFAM	SSF48403 SSF56112
PROSITE	PS50297 PS50088 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003151	outflow tract morphogenesis	PMID:24131868^[1]	ECO:0000315			P		Figure 1 - OFT is observed to be dilated and malformed.	complete CACAO 8904
involved_in	GO:0003151	outflow tract morphogenesis	PMID:24131868^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:20675382^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	PMID:20675382^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:18325335^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001510364 RGD:620063 UniProtKB:Q13418	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001510364 RGD:620063 UniProtKB:Q13418 WB:WBGene00003931	P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028427 PANTHER:PTN001510364	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028427 MGI:MGI:1195267 PANTHER:PTN001510364 RGD:620063 UniProtKB:Q13418	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003079 MGI:MGI:1346881 MGI:MGI:2443258 PANTHER:PTN001908122 RGD:1359261 RGD:619908 RGD:620063 TAIR:locus:2144613 UniProtKB:O43283 UniProtKB:P04049 UniProtKB:P10398 UniProtKB:P15056 UniProtKB:P80192 UniProtKB:Q02779 UniProtKB:Q13418 UniProtKB:Q13546 UniProtKB:Q16584	F		Seeded From UniProt	complete
colocalizes_with	GO:0001725	stress fiber	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001510364 RGD:620063	C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001907370 RGD:3531 WB:WBGene00003030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000178	negative regulation of neural precursor cell proliferation	PMID:24719101^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103040	P	regulates_o_occurs_in:(EMAPA:32804) occurs_in:(EMAPA:32804)\|occurs_in:(EMAPA:19037) regulates_o_occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000178	negative regulation of neural precursor cell proliferation	PMID:24719101^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3653044,MGI:MGI:3767432	P	regulates_o_occurs_in:(EMAPA:32804) occurs_in:(EMAPA:32804)\|occurs_in:(EMAPA:19037) regulates_o_occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097435	supramolecular fiber organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050775	positive regulation of dendrite morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050772	positive regulation of axonogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048812	neuron projection morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045773	positive regulation of axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	PMID:12670870^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2655774	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043491	protein kinase B signaling	PMID:19349584^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3653044,MGI:MGI:4359600	P	occurs_in:(EMAPA:18577)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
part_of	GO:0043034	costamere	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032288	myelin assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030030	cell projection organization	PMID:19349584^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3653044,MGI:MGI:4359600	P	occurs_in:(EMAPA:18577) occurs_in:(CL:0000218)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:19349584^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3653044,MGI:MGI:4359600	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021675	nerve development	PMID:19349584^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3653044,MGI:MGI:4359600	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:19349584^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3653044,MGI:MGI:4359600	P	occurs_in:(EMAPA:18577)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014044	Schwann cell development	PMID:19349584^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3653044,MGI:MGI:4359600	P	occurs_in:(EMAPA:18577) results_in_development_of:(CL:0000218)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010761	fibroblast migration	PMID:23658024^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009967	positive regulation of signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:12835312^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668459	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007569	cell aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	PMID:9366252^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:23658024^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:15565145^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16346)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:12432066^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:11304546^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99J82	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9366252^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13418	P		Seeded From UniProt	complete
colocalizes_with	GO:0001725	stress fiber	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:15831470^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001558	regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620063	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	F		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13418 ensembl:ENSP00000379975	P		Seeded From UniProt	complete
involved_in	GO:0097435	supramolecular fiber organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0050775	positive regulation of dendrite morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0050772	positive regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0045773	positive regulation of axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
part_of	GO:0043034	costamere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0032288	myelin assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	F		Seeded From UniProt	complete
involved_in	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	F		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	C		Seeded From UniProt	complete
involved_in	GO:0001558	regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J82 ensembl:ENSRNOP00000025906	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HWF0 ensembl:ENSP00000379975	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HWF0 ensembl:ENSP00000379975	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HWF0 ensembl:ENSP00000379975	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HWF0 ensembl:ENSP00000379975	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0313	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Dai, X et al. (2013) Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 11 107 PubMed GONUTS page
↑ ^2.0 ^2.1 Su, JL et al. (2010) CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J. Biol. Chem. 285 31325-36 PubMed GONUTS page
↑ Matsuda, C et al. (2008) Affixin activates Rac1 via betaPIX in C2C12 myoblast. FEBS Lett. 582 1189-96 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Porcheri, C et al. (2014) Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. J. Neurosci. 34 5222-32 PubMed GONUTS page
↑ Sakai, T et al. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 17 926-40 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Pereira, JA et al. (2009) Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J. Cell Biol. 185 147-61 PubMed GONUTS page
↑ ^8.0 ^8.1 Moik, D et al. (2013) Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice. J. Biol. Chem. 288 18863-71 PubMed GONUTS page
↑ Terpstra, L et al. (2003) Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J. Cell Biol. 162 139-48 PubMed GONUTS page
↑ ^10.0 ^10.1 Li, F et al. (1997) Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim. Biophys. Acta 1358 215-20 PubMed GONUTS page
↑ Bock-Marquette, I et al. (2004) Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432 466-72 PubMed GONUTS page
↑ Zhang, Y et al. (2002) Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J. Cell. Sci. 115 4777-86 PubMed GONUTS page
↑ Nikolopoulos, SN & Turner, CE (2001) Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. J. Biol. Chem. 276 23499-505 PubMed GONUTS page
↑ Leung-Hagesteijn, C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol. Cell. Biol. 25 3648-57 PubMed GONUTS page

[PMID:24131868-1] 1.0 ^1.1 Dai, X et al. (2013) Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 11 107 PubMed GONUTS page

[PMID:20675382-2] 2.0 ^2.1 Su, JL et al. (2010) CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J. Biol. Chem. 285 31325-36 PubMed GONUTS page

[PMID:18325335-3] Matsuda, C et al. (2008) Affixin activates Rac1 via betaPIX in C2C12 myoblast. FEBS Lett. 582 1189-96 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24719101-5] 5.0 ^5.1 Porcheri, C et al. (2014) Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. J. Neurosci. 34 5222-32 PubMed GONUTS page

[PMID:12670870-6] Sakai, T et al. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 17 926-40 PubMed GONUTS page

[PMID:19349584-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Pereira, JA et al. (2009) Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J. Cell Biol. 185 147-61 PubMed GONUTS page

[PMID:23658024-8] 8.0 ^8.1 Moik, D et al. (2013) Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice. J. Biol. Chem. 288 18863-71 PubMed GONUTS page

[PMID:12835312-9] Terpstra, L et al. (2003) Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J. Cell Biol. 162 139-48 PubMed GONUTS page

[PMID:9366252-10] 10.0 ^10.1 Li, F et al. (1997) Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim. Biophys. Acta 1358 215-20 PubMed GONUTS page

[PMID:15565145-11] Bock-Marquette, I et al. (2004) Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432 466-72 PubMed GONUTS page

[PMID:12432066-12] Zhang, Y et al. (2002) Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J. Cell. Sci. 115 4777-86 PubMed GONUTS page

[PMID:11304546-13] Nikolopoulos, SN & Turner, CE (2001) Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. J. Biol. Chem. 276 23499-505 PubMed GONUTS page

[PMID:15831470-14] Leung-Hagesteijn, C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol. Cell. Biol. 25 3648-57 PubMed GONUTS page

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MOUSE:ILK

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