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MOUSE:IFT56
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Ttc26 (ECO:0000312 with MGI:MGI:2444853) | |
Protein Name(s) | Intraflagellar transport protein 56 (ECO:0000303 with PMID:24596149[1])
Protein hop-sterile (ECO:0000303 with PMID:25340710[2]) Tetratricopeptide repeat protein 26 (ECO:0000312 with MGI:MGI:2444853) TPR repeat protein 26 (ECO:0000312 with MGI:MGI:2444853) | |
External Links | ||
UniProt | Q8BS45 | |
EMBL | AK035185 BC066060 | |
CCDS | CCDS51750.1 | |
RefSeq | NP_705828.2 | |
UniGene | Mm.253446 | |
ProteinModelPortal | Q8BS45 | |
STRING | 10090.ENSMUSP00000124369 | |
iPTMnet | Q8BS45 | |
PhosphoSitePlus | Q8BS45 | |
MaxQB | Q8BS45 | |
PaxDb | Q8BS45 | |
PRIDE | Q8BS45 | |
DNASU | 264134 | |
Ensembl | ENSMUST00000162554 | |
GeneID | 264134 | |
KEGG | mmu:264134 | |
UCSC | uc009bkc.1 | |
CTD | 79989 | |
MGI | MGI:2444853 | |
eggNOG | KOG3785 ENOG410XRMP | |
GeneTree | ENSGT00390000000159 | |
HOGENOM | HOG000258854 | |
HOVERGEN | HBG108610 | |
InParanoid | Q8BS45 | |
KO | K19685 | |
OMA | VEYMIRI | |
OrthoDB | EOG091G04RS | |
PhylomeDB | Q8BS45 | |
TreeFam | TF105816 | |
Reactome | [www.reactome.org/content/detail/R-MMU-5620924 R-MMU-5620924] | |
PRO | PR:Q8BS45 | |
Proteomes | UP000000589 | |
Bgee | ENSMUSG00000056832 | |
CleanEx | MM_TTC26 | |
ExpressionAtlas | Q8BS45 | |
Genevisible | Q8BS45 | |
GO | GO:0005813 GO:0036064 GO:0005929 GO:0030992 GO:0060271 GO:0042073 GO:0046530 GO:0008594 GO:0007224 GO:0007286 | |
Gene3D | 1.25.40.10 | |
InterPro | IPR013026 IPR011990 IPR030511 | |
PANTHER | PTHR14781:SF1 | |
SUPFAM | SSF48452 | |
PROSITE | PS50293 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0036064 |
ciliary basal body |
ECO:0000314 |
C |
Organism: Mus musculus Protein TTC26/DYF13 // Ttc26 Figure 1B : "Endogenous mouse TTC26, detected by antibody staining, exclusively localized to primary cilia and basal bodies in IMCD3 cells, which derived from mouse kidney collecting ducts (Figure 1B)." |
complete | |||||
GO:0005929 |
cilium |
ECO:0000314 |
C |
Organism: Mus Musculus Protein: TTC26/DYF13 // Ttc26 Figure 1B "Endogenous TTC26 showed punctate localizations along the length of the primary cilium, resembling the pattern usually seen with IFT proteins." |
complete | |||||
involved_in |
GO:0035082 |
axoneme assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061512 |
protein localization to cilium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007224 |
smoothened signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030992 |
intraciliary transport particle B |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042073 |
intraciliary transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007224 |
smoothened signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0120170 |
intraciliary transport particle B binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444853 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0097546 |
ciliary base |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000381369 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444853 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035735 |
intraciliary transport involved in cilium assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000381369 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035720 |
intraciliary anterograde transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000381369 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031514 |
motile cilium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000381369 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030992 |
intraciliary transport particle B |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444853 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1905198 |
manchette assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856054 |
P |
occurs_in:(CL:0000018) |
Seeded From UniProt |
complete | |
enables |
GO:0120170 |
intraciliary transport particle B binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060271 |
cilium assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046530 |
photoreceptor cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0036064 |
ciliary basal body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:28370) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0035720 |
intraciliary anterograde transport |
ECO:0000305 |
curator inference used in manual assertion |
GO:0120170 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008594 |
photoreceptor cell morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007286 |
spermatid development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856055 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000210) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005929 |
cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1561363 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2N8 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005929 |
cilium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ishikawa, H et al. (2014) TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Elife 3 e01566 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Swiderski, RE et al. (2014) A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. PLoS Genet. 10 e1004689 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Xin, D et al. (2017) IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture. Development 144 1544-1553 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Zhang, Q et al. (2012) Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish. Mol. Biol. Cell 23 3069-78 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Schumacher, JM et al. (1998) Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Biol. Reprod. 59 69-76 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Follit, JA et al. (2009) Characterization of mouse IFT complex B. Cell Motil. Cytoskeleton 66 457-68 PubMed GONUTS page
- ↑ Bryan, JH (1981) Spermatogenesis revisited. V. Spermiogenesis in mice homozygous for two different male-sterile mutations (ps and hpy). Cell Tissue Res. 221 169-80 PubMed GONUTS page
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