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MOUSE:IFT56

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ttc26 (ECO:0000312 with MGI:MGI:2444853)
Protein Name(s) Intraflagellar transport protein 56 (ECO:0000303 with PMID:24596149[1])

Protein hop-sterile (ECO:0000303 with PMID:25340710[2]) Tetratricopeptide repeat protein 26 (ECO:0000312 with MGI:MGI:2444853) TPR repeat protein 26 (ECO:0000312 with MGI:MGI:2444853)

External Links
UniProt Q8BS45
EMBL AK035185
BC066060
CCDS CCDS51750.1
RefSeq NP_705828.2
UniGene Mm.253446
ProteinModelPortal Q8BS45
STRING 10090.ENSMUSP00000124369
iPTMnet Q8BS45
PhosphoSitePlus Q8BS45
MaxQB Q8BS45
PaxDb Q8BS45
PRIDE Q8BS45
DNASU 264134
Ensembl ENSMUST00000162554
GeneID 264134
KEGG mmu:264134
UCSC uc009bkc.1
CTD 79989
MGI MGI:2444853
eggNOG KOG3785
ENOG410XRMP
GeneTree ENSGT00390000000159
HOGENOM HOG000258854
HOVERGEN HBG108610
InParanoid Q8BS45
KO K19685
OMA VEYMIRI
OrthoDB EOG091G04RS
PhylomeDB Q8BS45
TreeFam TF105816
Reactome [www.reactome.org/content/detail/R-MMU-5620924 R-MMU-5620924]
PRO PR:Q8BS45
Proteomes UP000000589
Bgee ENSMUSG00000056832
CleanEx MM_TTC26
ExpressionAtlas Q8BS45
Genevisible Q8BS45
GO GO:0005813
GO:0036064
GO:0005929
GO:0030992
GO:0060271
GO:0042073
GO:0046530
GO:0008594
GO:0007224
GO:0007286
Gene3D 1.25.40.10
InterPro IPR013026
IPR011990
IPR030511
PANTHER PTHR14781:SF1
SUPFAM SSF48452
PROSITE PS50293

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0036064

ciliary basal body

PMID:24596149[1]

ECO:0000314

C

Organism: Mus musculus Protein TTC26/DYF13 // Ttc26 Figure 1B : "Endogenous mouse TTC26, detected by antibody staining, exclusively localized to primary cilia and basal bodies in IMCD3 cells, which derived from mouse kidney collecting ducts (Figure 1B)."

complete
CACAO 12855

GO:0005929

cilium

PMID:24596149[1]

ECO:0000314

C

Organism: Mus Musculus Protein: TTC26/DYF13 // Ttc26 Figure 1B "Endogenous TTC26 showed punctate localizations along the length of the primary cilium, resembling the pattern usually seen with IFT proteins."

complete
CACAO 12858

involved_in

GO:0035082

axoneme assembly

PMID:28264835[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061512

protein localization to cilium

PMID:28264835[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

PMID:28264835[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

PMID:24596149[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:24596149[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:24596149[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042073

intraciliary transport

PMID:25340710[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

PMID:25340710[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:22718903[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:22718903[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0120170

intraciliary transport particle B binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444853
PANTHER:PTN000381369

F

Seeded From UniProt

complete

part_of

GO:0097546

ciliary base

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000381369
UniProtKB:Q57ZL2

C

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444853
PANTHER:PTN000381369
UniProtKB:Q57ZL2

C

Seeded From UniProt

complete

involved_in

GO:0035735

intraciliary transport involved in cilium assembly

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000381369
UniProtKB:Q57ZL2

P

Seeded From UniProt

complete

involved_in

GO:0035720

intraciliary anterograde transport

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000381369
UniProtKB:Q57ZL2

P

Seeded From UniProt

complete

part_of

GO:0031514

motile cilium

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000381369
UniProtKB:A8JA42

C

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444853
PANTHER:PTN000381369
UniProtKB:A8JA42
UniProtKB:Q57ZL2

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905198

manchette assembly

PMID:9674995[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856054

P

occurs_in:(CL:0000018)

Seeded From UniProt

complete

enables

GO:0120170

intraciliary transport particle B binding

PMID:19253336[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060271

cilium assembly

PMID:22718903[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5PR66

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046530

photoreceptor cell differentiation

PMID:22718903[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5PR66

P

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:22718903[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:28370)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035720

intraciliary anterograde transport

PMID:19253336[7]

ECO:0000305

curator inference used in manual assertion

GO:0120170

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008594

photoreceptor cell morphogenesis

PMID:22718903[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5PR66

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007286

spermatid development

PMID:7317942[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1856055

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:22718903[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000210)

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:19253336[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1561363

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:19253336[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5U2N8
ensembl:ENSRNOP00000034588

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969
UniProtKB-SubCell:SL-0066

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ishikawa, H et al. (2014) TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Elife 3 e01566 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Swiderski, RE et al. (2014) A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. PLoS Genet. 10 e1004689 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Xin, D et al. (2017) IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture. Development 144 1544-1553 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Zhang, Q et al. (2012) Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish. Mol. Biol. Cell 23 3069-78 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Schumacher, JM et al. (1998) Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Biol. Reprod. 59 69-76 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Follit, JA et al. (2009) Characterization of mouse IFT complex B. Cell Motil. Cytoskeleton 66 457-68 PubMed GONUTS page
  8. ↑ Bryan, JH (1981) Spermatogenesis revisited. V. Spermiogenesis in mice homozygous for two different male-sterile mutations (ps and hpy). Cell Tissue Res. 221 169-80 PubMed GONUTS page
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