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MOUSE:IFNA1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ifna1
Protein Name(s) Interferon alpha-1

IFN-alpha-1

External Links
UniProt P01572
EMBL X01974
AY225950
BX530016
CH466527
CCDS CCDS18347.1
PIR A01836
S62682
RefSeq NP_034632.2
UniGene Mm.57127
ProteinModelPortal P01572
SMR P01572
STRING 10090.ENSMUSP00000092580
PhosphoSite P01572
PaxDb P01572
PRIDE P01572
DNASU 15962
Ensembl ENSMUST00000094972
GeneID 15962
KEGG mmu:15962
UCSC uc008toc.1
CTD 3439
MGI MGI:107668
eggNOG ENOG410J735
ENOG410ZH91
GeneTree ENSGT00760000119150
HOVERGEN HBG052086
InParanoid P01572
KO K05414
OMA MEETPLM
OrthoDB EOG7M98HV
TreeFam TF336177
Reactome R-MMU-909733
R-MMU-912694
R-MMU-933541
R-MMU-983231
SABIO-RK P01572
NextBio 288712
PRO PR:P01572
Proteomes UP000000589
Bgee P01572
CleanEx MM_IFNA1
Genevisible P01572
GO GO:0005576
GO:0005615
GO:0005125
GO:0005132
GO:0002250
GO:0030183
GO:0042100
GO:0019221
GO:0042742
GO:0051607
GO:0006959
GO:0002323
GO:0033141
GO:0043330
GO:0002286
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR000471
PANTHER PTHR11691
Pfam PF00143
PRINTS PR00266
SMART SM00076
SUPFAM SSF47266
PROSITE PS00252

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0060337

type I interferon signaling pathway

PMID:24784232[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:24784232[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050691

regulation of defense response to virus by host

PMID:24784232[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043330

response to exogenous dsRNA

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000914537
UniProtKB:P01574

P

Seeded From UniProt

complete

involved_in

GO:0042100

B cell proliferation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107657
PANTHER:PTN000914537

P

Seeded From UniProt

complete

involved_in

GO:0033141

positive regulation of peptidyl-serine phosphorylation of STAT protein

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000914537
UniProtKB:P01574

P

Seeded From UniProt

complete

involved_in

GO:0030183

B cell differentiation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2448469
PANTHER:PTN000914537

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2448469
PANTHER:PTN000914537
UniProtKB:Q9P0W0

P

Seeded From UniProt

complete

involved_in

GO:0006959

humoral immune response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107657
PANTHER:PTN000914537

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107657
MGI:MGI:107659
MGI:MGI:107662
MGI:MGI:107664
MGI:MGI:107668
PANTHER:PTN000914537

C

Seeded From UniProt

complete

enables

GO:0005132

type I interferon receptor binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107657
MGI:MGI:2448469
PANTHER:PTN000914537
UniProtKB:Q9P0W0

F

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107657
MGI:MGI:107668
PANTHER:PTN000914537
UniProtKB:P01574

F

Seeded From UniProt

complete

involved_in

GO:0002323

natural killer cell activation involved in immune response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107659
MGI:MGI:107664
MGI:MGI:107668
PANTHER:PTN000914537

P

Seeded From UniProt

complete

involved_in

GO:0002286

T cell activation involved in immune response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107668
PANTHER:PTN000914537

P

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107657
PANTHER:PTN000914537

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051607

defense response to virus

PMID:19130550[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042742

defense response to bacterium

PMID:15240719[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:19130550[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:15240719[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002323

natural killer cell activation involved in immune response

PMID:19130550[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002286

T cell activation involved in immune response

PMID:19130550[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

enables

GO:0005126

cytokine receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000471

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000471

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000471

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-MMU-912695

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Marchant, DJ et al. (2014) A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat. Med. 20 493-502 PubMed GONUTS page
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gerlach, N et al. (2009) Anti-retroviral effects of type I IFN subtypes in vivo. Eur. J. Immunol. 39 136-46 PubMed GONUTS page
  4. ↑ 4.0 4.1 Schiavoni, G et al. (2004) Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway. J. Immunol. 173 1266-75 PubMed GONUTS page
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