MOUSE:HXK4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gck (synonyms: Gk)
Protein Name(s)	Glucokinase Hexokinase type IV HK IV Hexokinase-4 HK4 Hexokinase-D
External Links
UniProt	P52792
EMBL	L38990 L41631 BC011139 M58755
CCDS	CCDS24409.1 CCDS70135.1
PIR	I49693 I49694
RefSeq	NP_001274315.1 NP_034422.2
UniGene	Mm.220358
ProteinModelPortal	P52792
SMR	P52792
BioGrid	222262
BindingDB	P52792
ChEMBL	CHEMBL3112387
PhosphoSite	P52792
MaxQB	P52792
PaxDb	P52792
PRIDE	P52792
Ensembl	ENSMUST00000102920 ENSMUST00000109822 ENSMUST00000109823
GeneID	103988
KEGG	mmu:103988
UCSC	uc007hxn.1
CTD	2645
MGI	MGI:1270854
eggNOG	COG5026
HOGENOM	HOG000162670
HOVERGEN	HBG000142
InParanoid	P52792
KO	K12407
OMA	EDHQCEV
OrthoDB	EOG7S21X5
PhylomeDB	P52792
TreeFam	TF314238
Reactome	REACT_204192 REACT_214529 REACT_253543
SABIO-RK	P52792
NextBio	356305
PRO	PR:P52792
Proteomes	UP000000589
Bgee	P52792
CleanEx	MM_GCK
ExpressionAtlas	P52792
Genevestigator	P52792
GO	GO:0005884 GO:0045180 GO:0005829 GO:0005739 GO:0005654 GO:0005634 GO:0030141 GO:0043531 GO:0005524 GO:0004340 GO:0005536 GO:0000287 GO:0070509 GO:0046835 GO:0001678 GO:0042149 GO:0032869 GO:0044320 GO:0051594 GO:0031018 GO:0006003 GO:0042593 GO:0006006 GO:0005978 GO:0006096 GO:0055088 GO:0006739 GO:0032811 GO:0045721 GO:0007204 GO:0045725 GO:0045821 GO:0032024 GO:0042327 GO:0050796 GO:0043266 GO:0019932
InterPro	IPR001312 IPR022673 IPR019807 IPR022672
PANTHER	PTHR19443
Pfam	PF00349 PF03727
PRINTS	PR00475
PROSITE	PS00378

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032811	negative regulation of epinephrine secretion	PMID:30146176^[1]	ECO:0000315			P		Figure 4g shows that when GCK is knocked out in mice, plasma epinephrine levels rise significantly.	complete CACAO 13356
	GO:0004340	glucokinase activity	PMID:30146176^[1]	ECO:0000315			F		Supplementary figures 1a and 1b show that GCK mutant mice show reduced glucose phosphorylating activity in the liver and pancreas.	complete CACAO 13359
	GO:0004340	glucokinase activity	PMID:22698525^[2]	ECO:0000315			F		See Figure 1 of how Munich GckD217V mutants affect glucokinase activity.	complete CACAO 5278
	GO:0004396	hexokinase activity	PMID:23085254^[3]	ECO:0000315			F		Figure 7	complete CACAO 5698
enables	GO:0004396	hexokinase activity	PMID:23085254^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:22698525^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10713097^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	PMID:18477811^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051594	detection of glucose	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:18477811^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:18477811^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35557	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35557	F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35557	F		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 PANTHER:PTN000455411 UniProtKB:P35557	P		Seeded From UniProt	complete
enables	GO:0019158	mannokinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c	F		Seeded From UniProt	complete
enables	GO:0008865	fructokinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P93834 UniProtKB:Q4WHC3	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000000545 SGD:S000001949 SGD:S000003222	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000003222 UniProtKB:C6KT76 UniProtKB:P35557	C		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c RGD:2670 RGD:2796 SGD:S000000545 TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P35557 UniProtKB:P93834 UniProtKB:Q4WCS2 UniProtKB:Q4WHC3 UniProtKB:Q5W676 UniProtKB:Q8LQ68	F		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 PANTHER:PTN000455350 RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055088	lipid homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051594	detection of glucose	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051594	detection of glucose	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050796	regulation of insulin secretion	PMID:8954920^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177703	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050796	regulation of insulin secretion	PMID:8530440^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177703	P	regulates_o_occurs_in:(EMAPA:32927) regulates_o_occurs_in:(CL:0000169)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050796	regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046835	carbohydrate phosphorylation	PMID:7665557^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861929	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046835	carbohydrate phosphorylation	PMID:7556622^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046835	carbohydrate phosphorylation	PMID:3931624^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046835	carbohydrate phosphorylation	PMID:141272^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046835	carbohydrate phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045821	positive regulation of glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
part_of	GO:0045180	basal cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044320	cellular response to leptin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
enables	GO:0043531	ADP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043266	regulation of potassium ion transport	PMID:9662046^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177703	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:9867845^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177710	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:9357804^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861929	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:8530440^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177703	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:7556622^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042149	cellular response to glucose starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032869	cellular response to insulin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032811	negative regulation of epinephrine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	PMID:7556622^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019932	second-messenger-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006739	NADP metabolic process	PMID:9873043^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:32927) occurs_in:(CL:0000169)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006096	glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:9357804^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861929	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:7665557^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861929	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:7556622^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:3931624^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:141272^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006003	fructose 2,6-bisphosphate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0005978	glycogen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:24187134^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000169)\|part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[18]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12931191^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24187134^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	C		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	F		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:9357804^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861929	F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:7665557^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861929	F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:7556622^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:7510884^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:9873043^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:3931624^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:141272^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:10713097^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P35557	F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001678	cellular glucose homeostasis	PMID:7553875^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857469	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001678	cellular glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2670	F		Seeded From UniProt	complete
involved_in	GO:0051594	detection of glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	P		Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	P		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	P		Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	C		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	F		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35557 ensembl:ENSP00000223366	F		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	P		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039073	F		Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807 InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR039073	F		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR022672 InterPro:IPR022673	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019807	P		Seeded From UniProt	complete
enables	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022672 InterPro:IPR022673	F		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039073	P		Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.2	F		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	Reactome:R-MMU-210774	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9625102 Reactome:R-MMU-186510	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chakera, AJ et al. (2018) Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes. Mol Metab PubMed GONUTS page
↑ ^2.0 ^2.1 van Buerck, L et al. (2012) Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants. Mol. Cell. Endocrinol. 362 139-48 PubMed GONUTS page
↑ ^3.0 ^3.1 Guo, T et al. (2012) Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age. Biomed. Pharmacother. 66 587-96 PubMed GONUTS page
↑ ^4.0 ^4.1 Grimsby, J et al. (2000) Characterization of glucokinase regulatory protein-deficient mice. J. Biol. Chem. 275 7826-31 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Goldsworthy, M et al. (2008) Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes 57 2234-44 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Aizawa, T et al. (1996) Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene. Biochem. Biophys. Res. Commun. 229 460-5 PubMed GONUTS page
↑ ^8.0 ^8.1 Terauchi, Y et al. (1995) Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J. Biol. Chem. 270 30253-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bali, D et al. (1995) Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J. Biol. Chem. 270 21464-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Ishihara, H et al. (1995) Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance. FEBS Lett. 371 329-32 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 James, PA et al. (1985) Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity. Biochem. Genet. 23 525-38 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Coleman, DL (1977) Genetic control of glucokinase activity in mice. Biochem. Genet. 15 297-305 PubMed GONUTS page
↑ Sakura, H et al. (1998) Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. Diabetologia 41 654-9 PubMed GONUTS page
↑ Postic, C et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274 305-15 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Rossetti, L et al. (1997) Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. Am. J. Physiol. 273 E743-50 PubMed GONUTS page
↑ ^16.0 ^16.1 Piston, DW et al. (1999) Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J. Biol. Chem. 274 1000-4 PubMed GONUTS page
↑ ^17.0 ^17.1 Hofmeister-Brix, A et al. (2013) Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. J. Biol. Chem. 288 35824-39 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page
↑ Efrat, S et al. (1994) Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc. Natl. Acad. Sci. U.S.A. 91 2051-5 PubMed GONUTS page
↑ Grupe, A et al. (1995) Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83 69-78 PubMed GONUTS page

[PMID:30146176-1] 1.0 ^1.1 Chakera, AJ et al. (2018) Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes. Mol Metab PubMed GONUTS page

[PMID:22698525-2] 2.0 ^2.1 van Buerck, L et al. (2012) Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants. Mol. Cell. Endocrinol. 362 139-48 PubMed GONUTS page

[PMID:23085254-3] 3.0 ^3.1 Guo, T et al. (2012) Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age. Biomed. Pharmacother. 66 587-96 PubMed GONUTS page

[PMID:10713097-4] 4.0 ^4.1 Grimsby, J et al. (2000) Characterization of glucokinase regulatory protein-deficient mice. J. Biol. Chem. 275 7826-31 PubMed GONUTS page

[PMID:18477811-5] 5.0 ^5.1 ^5.2 Goldsworthy, M et al. (2008) Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes 57 2234-44 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8954920-7] Aizawa, T et al. (1996) Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene. Biochem. Biophys. Res. Commun. 229 460-5 PubMed GONUTS page

[PMID:8530440-8] 8.0 ^8.1 Terauchi, Y et al. (1995) Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J. Biol. Chem. 270 30253-6 PubMed GONUTS page

[PMID:7665557-9] 9.0 ^9.1 ^9.2 Bali, D et al. (1995) Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J. Biol. Chem. 270 21464-7 PubMed GONUTS page

[PMID:7556622-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Ishihara, H et al. (1995) Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance. FEBS Lett. 371 329-32 PubMed GONUTS page

[PMID:3931624-11] 11.0 ^11.1 ^11.2 James, PA et al. (1985) Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity. Biochem. Genet. 23 525-38 PubMed GONUTS page

[PMID:141272-12] 12.0 ^12.1 ^12.2 Coleman, DL (1977) Genetic control of glucokinase activity in mice. Biochem. Genet. 15 297-305 PubMed GONUTS page

[PMID:9662046-13] Sakura, H et al. (1998) Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. Diabetologia 41 654-9 PubMed GONUTS page

[PMID:9867845-14] Postic, C et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274 305-15 PubMed GONUTS page

[PMID:9357804-15] 15.0 ^15.1 ^15.2 Rossetti, L et al. (1997) Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. Am. J. Physiol. 273 E743-50 PubMed GONUTS page

[PMID:9873043-16] 16.0 ^16.1 Piston, DW et al. (1999) Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J. Biol. Chem. 274 1000-4 PubMed GONUTS page

[PMID:24187134-17] 17.0 ^17.1 Hofmeister-Brix, A et al. (2013) Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. J. Biol. Chem. 288 35824-39 PubMed GONUTS page

[PMID:14651853-18] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:12931191-19] Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page

[PMID:7510884-20] Efrat, S et al. (1994) Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc. Natl. Acad. Sci. U.S.A. 91 2051-5 PubMed GONUTS page

[PMID:7553875-21] Grupe, A et al. (1995) Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83 69-78 PubMed GONUTS page

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