MOUSE:GRM5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grm5 (synonyms: Gprc1e, Mglur5)
Protein Name(s)	Metabotropic glutamate receptor 5 mGluR5
External Links
UniProt	Q3UVX5
EMBL	AK136840 AC113033 AC113115 AC116820 AC149088 AC163218
CCDS	CCDS52305.1
RefSeq	NP_001137306.1 XP_006507245.1 XP_006507246.1
UniGene	Mm.235018
ProteinModelPortal	Q3UVX5
SMR	Q3UVX5
BioGrid	223809
IntAct	Q3UVX5
ChEMBL	CHEMBL1641352
GuidetoPHARMACOLOGY	293
PhosphoSite	Q3UVX5
MaxQB	Q3UVX5
PaxDb	Q3UVX5
PRIDE	Q3UVX5
Ensembl	ENSMUST00000167164
GeneID	108071
KEGG	mmu:108071
UCSC	uc009ifp.2 uc009ifs.2
CTD	2915
MGI	MGI:1351342
eggNOG	NOG295200
GeneTree	ENSGT00760000118884
HOGENOM	HOG000218636
HOVERGEN	HBG107965
InParanoid	Q3UVX5
KO	K04604
OMA	APLCSSY
PhylomeDB	Q3UVX5
TreeFam	TF313240
Reactome	REACT_207651 REACT_262510
NextBio	359988
PRO	PR:Q3UVX5
Proteomes	UP000000589
Bgee	Q3UVX5
CleanEx	MM_GRM5
ExpressionAtlas	Q3UVX5
Genevestigator	Q3UVX5
GO	GO:0097449 GO:0005737 GO:0043198 GO:0043197 GO:0070062 GO:0005887 GO:0043005 GO:0005886 GO:0014069 GO:0004930 GO:0008066 GO:0001639 GO:0000185 GO:0002029 GO:0007216 GO:0007612 GO:0007626 GO:0040013 GO:0007206 GO:0048170 GO:0007205 GO:0006468 GO:0048169 GO:0051966 GO:0006355 GO:0007268
InterPro	IPR001828 IPR000337 IPR011500 IPR017978 IPR017979 IPR000162 IPR000202 IPR019588 IPR028082
Pfam	PF00003 PF01094 PF10606 PF07562
PRINTS	PR00248 PR01055 PR00593
SUPFAM	SSF53822
PROSITE	PS00979 PS00980 PS00981 PS50259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043005	neuron projection	PMID:21795692^[1]	ECO:0000315			C		Shank3 mutant mice hippocampal neurons, figure 1C and D, there was reduction of mGluR5 protein in synaptosomes in hippocampal culture.	complete CACAO 3096
enables	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	PMID:19169252^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0060076) occurs_in:(CL:0000598) occurs_in:(UBERON:0000451)	Seeded From UniProt	complete
enables	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	PMID:22586220^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0060076) occurs_in:(CL:1001571) occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:24012003^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0000540) regulates:(GO:0035584)	Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	PMID:24012003^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925	P	part_of:(GO:1904646) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:24012003^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023,UniProtKB:P49769	P	part_of:(GO:0090647) happens_during:(GO:0007568) occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:24012003^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023,UniProtKB:P49769	P	happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:24012003^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023,UniProtKB:P49769	P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:24012003^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	has_regulation_target:(UniProtKB:P39688) occurs_in:(CL:0002609)	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41594	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21795692^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41594	F		Seeded From UniProt	complete
involved_in	GO:0007216	G protein-coupled glutamate receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41594	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41594	C		Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	PMID:11431513^[5]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	PMID:11431513^[5]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:11431513^[5]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:11431513^[5]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351338 MGI:MGI:1351342 PANTHER:PTN002514246	F		Seeded From UniProt	complete
involved_in	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000710923 RGD:2746	P		Seeded From UniProt	complete
enables	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351342 PANTHER:PTN002514246 RGD:2742	F		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002514246 RGD:2742 RGD:2746	C		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019985 PANTHER:PTN001173581 RGD:2742	P		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001173581 RGD:2746 UniProtKB:O00222 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14831 UniProtKB:Q14833	F		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001173581 RGD:2746 UniProtKB:A0A0B4KF15 UniProtKB:O00222 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14831 UniProtKB:Q14833	F		Seeded From UniProt	complete
involved_in	GO:0007216	G protein-coupled glutamate receptor signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019985 PANTHER:PTN001173581 RGD:2742 RGD:2746 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000206 FB:FBgn0019985 PANTHER:PTN001173583 RGD:619858 UniProtKB:A0A0B4KF15 UniProtKB:O15303 UniProtKB:P41594 UniProtKB:Q13255 UniProtKB:Q14833	C		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902938	regulation of intracellular calcium activated chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	C		Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	C		Seeded From UniProt	complete
part_of	GO:0097449	astrocyte projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050890	cognition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:16024054^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857437	P	regulates_o_occurs_in:(EMAPA:32768) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040013	negative regulation of locomotion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035584	calcium-mediated signaling using intracellular calcium source	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	P		Seeded From UniProt	complete
enables	GO:0031687	A2A adenosine receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	C		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	F		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:16280580^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94924 MGI:MGI:99402	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:16280580^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857437	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:9185557^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857437	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007216	G protein-coupled glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007216	G protein-coupled glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006448	regulation of translational elongation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12176012^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12176012^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000185	activation of MAPKKK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2746	P		Seeded From UniProt	complete
involved_in	GO:0007206	phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001639	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099530	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099530	P		Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099583	P		Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099583	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	P		Seeded From UniProt	complete
involved_in	GO:1902938	regulation of intracellular calcium activated chloride channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	P		Seeded From UniProt	complete
involved_in	GO:0050890	cognition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	P		Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	P		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	F		Seeded From UniProt	complete
involved_in	GO:0007216	G protein-coupled glutamate receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	P		Seeded From UniProt	complete
involved_in	GO:0006448	regulation of translational elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	F		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41594 ensembl:ENSP00000306138	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000337 InterPro:IPR011500 InterPro:IPR017978 InterPro:IPR017979	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000162 InterPro:IPR000202 InterPro:IPR000337 InterPro:IPR011500 InterPro:IPR017978 InterPro:IPR017979	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000162 InterPro:IPR000202 InterPro:IPR000337 InterPro:IPR017978 InterPro:IPR017979	C		Seeded From UniProt	complete
enables	GO:0001639	PLC activating G protein-coupled glutamate receptor activity	PMID:9185557^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
↑ Sidiropoulou, K et al. (2009) Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat. Neurosci. 12 190-9 PubMed GONUTS page
↑ Kato, HK et al. (2012) Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells. J. Physiol. (Lond.) 590 3019-34 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Huber, KM et al. (2001) Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1. J. Neurophysiol. 86 321-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bortolotto, ZA et al. (2005) The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors. Neuropharmacology 49 Suppl 1 13-25 PubMed GONUTS page
↑ ^8.0 ^8.1 Kachroo, A et al. (2005) Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. J. Neurosci. 25 10414-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Lu, YM et al. (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 17 5196-205 PubMed GONUTS page
↑ ^10.0 ^10.1 Saito, H et al. (2002) An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem. Biophys. Res. Commun. 296 523-9 PubMed GONUTS page

[PMID:21795692-1] 1.0 ^1.1 Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page

[PMID:19169252-2] Sidiropoulou, K et al. (2009) Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat. Neurosci. 12 190-9 PubMed GONUTS page

[PMID:22586220-3] Kato, HK et al. (2012) Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells. J. Physiol. (Lond.) 590 3019-34 PubMed GONUTS page

[PMID:24012003-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page

[PMID:11431513-5] 5.0 ^5.1 ^5.2 ^5.3 Huber, KM et al. (2001) Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1. J. Neurophysiol. 86 321-5 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16024054-7] Bortolotto, ZA et al. (2005) The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors. Neuropharmacology 49 Suppl 1 13-25 PubMed GONUTS page

[PMID:16280580-8] 8.0 ^8.1 Kachroo, A et al. (2005) Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. J. Neurosci. 25 10414-9 PubMed GONUTS page

[PMID:9185557-9] 9.0 ^9.1 Lu, YM et al. (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 17 5196-205 PubMed GONUTS page

[PMID:12176012-10] 10.0 ^10.1 Saito, H et al. (2002) An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem. Biophys. Res. Commun. 296 523-9 PubMed GONUTS page

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MOUSE:GRM5

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