MOUSE:GRK5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grk5 (synonyms: Gprk5)
Protein Name(s)	G protein-coupled receptor kinase 5 G protein-coupled receptor kinase GRK5
External Links
UniProt	Q8VEB1
EMBL	AF040759 AF040755 AF040756 AF040757 AF040758 AF040746 BC019379
CCDS	CCDS29945.1
RefSeq	NP_061357.3
UniGene	Mm.279400 Mm.482751
ProteinModelPortal	Q8VEB1
SMR	Q8VEB1
DIP	DIP-46262N
IntAct	Q8VEB1
MINT	MINT-4096859
PhosphoSite	Q8VEB1
MaxQB	Q8VEB1
PaxDb	Q8VEB1
PRIDE	Q8VEB1
Ensembl	ENSMUST00000003313
GeneID	14773
KEGG	mmu:14773
UCSC	uc008ice.2
CTD	2869
MGI	MGI:109161
eggNOG	COG0515
GeneTree	ENSGT00770000120493
HOGENOM	HOG000006742
HOVERGEN	HBG004532
InParanoid	Q8VEB1
KO	K08291
OMA	NFYTKFN
OrthoDB	EOG7V1FQK
PhylomeDB	Q8VEB1
TreeFam	TF313940
Reactome	REACT_207651
ChiTaRS	Grk5
NextBio	286873
PRO	PR:Q8VEB1
Proteomes	UP000000589
Bgee	Q8VEB1
CleanEx	MM_GRK5
ExpressionAtlas	Q8VEB1
Genevestigator	Q8VEB1
GO	GO:0005737 GO:0005634 GO:0005886 GO:0005524 GO:0004703 GO:0008289 GO:0004674 GO:0006915 GO:0043066 GO:0046777 GO:0007217 GO:0038032 GO:0016055
InterPro	IPR000961 IPR000239 IPR011009 IPR000719 IPR017441 IPR016137 IPR002290
Pfam	PF00069 PF00615
PRINTS	PR00717
SMART	SM00315 SM00133 SM00220
SUPFAM	SSF48097 SSF56112
PROSITE	PS51285 PS00107 PS50011 PS50132

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0045444	fat cell differentiation	PMID:22507984^[1]	ECO:0000315			P	Figure 4: A, B and C GRK5 ablation impaired adipogenesis in White Adipose Tissue and adipocyte differentiation.	complete CACAO 6595
involved_in	GO:0045444	fat cell differentiation	PMID:22507984^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34947	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34947	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34947	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34947	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61985	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051726	regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	P	Seeded From UniProt	complete
enables	GO:0047696	beta-adrenergic receptor kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	P	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	C	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61985	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007217	tachykinin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P34947	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61985	P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	P	Seeded From UniProt	complete
enables	GO:0047696	beta-adrenergic receptor kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	F	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	P	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	C	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	C	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	P	Seeded From UniProt	complete
involved_in	GO:0007217	tachykinin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34947 ensembl:ENSP00000376609	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961	F	Seeded From UniProt	complete
enables	GO:0004703	G protein-coupled receptor kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000239	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000239 InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000239 InterPro:IPR000719 InterPro:IPR000961	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000239	P	Seeded From UniProt	complete
enables	GO:0004703	G protein-coupled receptor kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.16	F	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wang, F et al. (2012) GRK5 deficiency decreases diet-induced obesity and adipogenesis. Biochem. Biophys. Res. Commun. 421 312-7 PubMed GONUTS page

[PMID:22507984-1] 1.0 ^1.1 Wang, F et al. (2012) GRK5 deficiency decreases diet-induced obesity and adipogenesis. Biochem. Biophys. Res. Commun. 421 312-7 PubMed GONUTS page

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MOUSE:GRK5

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