MOUSE:GHRL

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ghrl (synonyms: Mtlrp)
Protein Name(s)	Appetite-regulating hormone Growth hormone secretagogue Growth hormone-releasing peptide Motilin-related peptide Protein M46 Ghrelin Obestatin
External Links
UniProt	Q9EQX0
EMBL	AJ243503 AB035701 AB060078 AK008658 AK008860
CCDS	CCDS20432.1
RefSeq	NP_001273333.1 NP_001273334.1 NP_001273335.1 NP_067463.2 XP_006506509.1
UniGene	Mm.379095
PDB	2JSH 2JSI 2JSJ
PDBsum	2JSH 2JSI 2JSJ
PhosphoSite	Q9EQX0
MaxQB	Q9EQX0
PaxDb	Q9EQX0
PRIDE	Q9EQX0
Ensembl	ENSMUST00000064993
GeneID	58991
KEGG	mmu:58991
UCSC	uc009dhj.1 uc009dhl.1
CTD	51738
MGI	MGI:1930008
eggNOG	NOG45924
GeneTree	ENSGT00390000004064
HOGENOM	HOG000236303
HOVERGEN	HBG018522
InParanoid	Q9EQX0
KO	K05254
OMA	EIQFNAP
OrthoDB	EOG741Z4K
PhylomeDB	Q9EQX0
TreeFam	TF336219
Reactome	REACT_207651 REACT_233293 REACT_235286
ChiTaRS	Ghrl
EvolutionaryTrace	Q9EQX0
NextBio	314490
PRO	PR:Q9EQX0
Proteomes	UP000000589
Bgee	Q9EQX0
CleanEx	MM_GHRL
ExpressionAtlas	Q9EQX0
Genevestigator	Q9EQX0
GO	GO:0030424 GO:0005737 GO:0005576 GO:0005615 GO:0031768 GO:0016608 GO:0005179 GO:0030296 GO:0008154 GO:0000187 GO:0008343 GO:0046697 GO:0016358 GO:0007186 GO:0001696 GO:0043066 GO:0042322 GO:0001937 GO:0050728 GO:0046676 GO:0032691 GO:0045409 GO:0040013 GO:0042536 GO:0032100 GO:0046010 GO:0051461 GO:0051464 GO:0007204 GO:0060124 GO:0032024 GO:0032097 GO:0051965 GO:0042127 GO:0060079 GO:0032095 GO:0043627 GO:0009725
InterPro	IPR006737 IPR006738 IPR005441
PANTHER	PTHR14122
Pfam	PF04643 PF04644
PRINTS	PR01624

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:19666521^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	P		Seeded From UniProt	complete
involved_in	GO:0045409	negative regulation of interleukin-6 biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0032097	positive regulation of response to food	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	P		Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	P		Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	F		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	F		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0008154	actin polymerization or depolymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYH7	F		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283 UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	P		Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283 UniProtKB:Q8AV73	F		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 UniProtKB:Q8AV73 UniProtKB:Q9GKY5 UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
involved_in	GO:0001696	gastric acid secretion	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000253	positive regulation of feeding behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905564	positive regulation of vascular endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905333	regulation of gastric motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904468	negative regulation of tumor necrosis factor secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904349	positive regulation of small intestine smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904346	positive regulation of gastric mucosal blood circulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904179	positive regulation of adipose tissue development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904000	positive regulation of eating behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903012	positive regulation of bone development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0120058	positive regulation of small intestinal transit	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099175	regulation of postsynapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099170	postsynaptic modulation of chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:16491079^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045041	P	occurs_in:(EMAPA:32768) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051969	regulation of transmission of nerve impulse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	PMID:16491079^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045041	P	regulates_o_occurs_in:(EMAPA:32768) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051464	positive regulation of cortisol secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051461	positive regulation of corticotropin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046697	decidualization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046676	negative regulation of insulin secretion	PMID:17130496^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3709886	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046676	negative regulation of insulin secretion	PMID:17130496^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9QYH7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045927	positive regulation of growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045409	negative regulation of interleukin-6 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040013	negative regulation of locomotion	PMID:16322795^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045041	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040010	positive regulation of growth rate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035483	gastric emptying	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032100	positive regulation of appetite	PMID:15070777^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2441906	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032100	positive regulation of appetite	PMID:17060947^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045041	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032100	positive regulation of appetite	PMID:15070777^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0032100	positive regulation of appetite	PMID:15148384^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045041	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0032100	positive regulation of appetite	PMID:14585959^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681803	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032097	positive regulation of response to food	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032095	regulation of response to food	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	F		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:16491079^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045041	P	occurs_in:(EMAPA:32768) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009725	response to hormone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5Y391	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008154	actin polymerization or depolymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10930375^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:10930375^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001696	gastric acid secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:632283	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030296	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030296	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030296	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099170	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099170	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:2000253	positive regulation of feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1905333	regulation of gastric motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1904468	negative regulation of tumor necrosis factor secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1904349	positive regulation of small intestine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1904346	positive regulation of gastric mucosal blood circulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1904179	positive regulation of adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1904000	positive regulation of eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:1903012	positive regulation of bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0120058	positive regulation of small intestinal transit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	C		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0051969	regulation of transmission of nerve impulse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0045927	positive regulation of growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0040010	positive regulation of growth rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0035483	gastric emptying	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0032097	positive regulation of response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	F		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	F		Seeded From UniProt	complete
involved_in	GO:0001696	gastric acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYH7 ensembl:ENSRNOP00000014103	F		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051464	positive regulation of cortisol secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051461	positive regulation of corticotropin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0045409	negative regulation of interleukin-6 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	F		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0008154	actin polymerization or depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006737 InterPro:IPR006738	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005441 InterPro:IPR006737 InterPro:IPR006738	C		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005441	F		Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	PMID:16322794^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008343	adult feeding behavior	PMID:16322794^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:10930375^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Szentirmai, E et al. (2009) The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc. Natl. Acad. Sci. U.S.A. 106 14069-74 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Diano, S et al. (2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9 381-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Dezaki, K et al. (2006) Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55 3486-93 PubMed GONUTS page
↑ Wortley, KE et al. (2005) Absence of ghrelin protects against early-onset obesity. J. Clin. Invest. 115 3573-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Sun, Y et al. (2004) Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc. Natl. Acad. Sci. U.S.A. 101 4679-84 PubMed GONUTS page
↑ Abizaid, A et al. (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116 3229-39 PubMed GONUTS page
↑ Wortley, KE et al. (2004) Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc. Natl. Acad. Sci. U.S.A. 101 8227-32 PubMed GONUTS page
↑ Sun, Y et al. (2003) Deletion of ghrelin impairs neither growth nor appetite. Mol. Cell. Biol. 23 7973-81 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Tomasetto, C et al. (2000) Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 119 395-405 PubMed GONUTS page
↑ ^11.0 ^11.1 Zigman, JM et al. (2005) Mice lacking ghrelin receptors resist the development of diet-induced obesity. J. Clin. Invest. 115 3564-72 PubMed GONUTS page

[PMID:19666521-1] Szentirmai, E et al. (2009) The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc. Natl. Acad. Sci. U.S.A. 106 14069-74 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16491079-3] 3.0 ^3.1 ^3.2 Diano, S et al. (2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9 381-8 PubMed GONUTS page

[PMID:17130496-4] 4.0 ^4.1 Dezaki, K et al. (2006) Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55 3486-93 PubMed GONUTS page

[PMID:16322795-5] Wortley, KE et al. (2005) Absence of ghrelin protects against early-onset obesity. J. Clin. Invest. 115 3573-8 PubMed GONUTS page

[PMID:15070777-6] 6.0 ^6.1 Sun, Y et al. (2004) Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc. Natl. Acad. Sci. U.S.A. 101 4679-84 PubMed GONUTS page

[PMID:17060947-7] Abizaid, A et al. (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116 3229-39 PubMed GONUTS page

[PMID:15148384-8] Wortley, KE et al. (2004) Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc. Natl. Acad. Sci. U.S.A. 101 8227-32 PubMed GONUTS page

[PMID:14585959-9] Sun, Y et al. (2003) Deletion of ghrelin impairs neither growth nor appetite. Mol. Cell. Biol. 23 7973-81 PubMed GONUTS page

[PMID:10930375-10] 10.0 ^10.1 ^10.2 Tomasetto, C et al. (2000) Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 119 395-405 PubMed GONUTS page

[PMID:16322794-11] 11.0 ^11.1 Zigman, JM et al. (2005) Mice lacking ghrelin receptors resist the development of diet-induced obesity. J. Clin. Invest. 115 3564-72 PubMed GONUTS page

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MOUSE:GHRL

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