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MOUSE:GALC
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Galc | |
| Protein Name(s) | Galactocerebrosidase
GALCERase Galactocerebroside beta-galactosidase Galactosylceramidase Galactosylceramide beta-galactosidase | |
| External Links | ||
| UniProt | P54818 | |
| EMBL | D38557 AF003886 AF003870 AF003871 AF003872 AF003873 AF003874 AF003875 AF003876 AF003877 AF003878 AF003879 AF003880 AF003881 AF003882 AF003883 AF003884 AF003885 AK154760 CH466549 BC086671 | |
| CCDS | CCDS36517.1 | |
| RefSeq | NP_032105.2 | |
| UniGene | Mm.5120 | |
| PDB | 3ZR5 3ZR6 4CCC 4CCD 4CCE | |
| PDBsum | 3ZR5 3ZR6 4CCC 4CCD 4CCE | |
| ProteinModelPortal | P54818 | |
| SMR | P54818 | |
| ChEMBL | CHEMBL2218 | |
| CAZy | GH59 | |
| PhosphoSite | P54818 | |
| MaxQB | P54818 | |
| PaxDb | P54818 | |
| PRIDE | P54818 | |
| Ensembl | ENSMUST00000021390 | |
| GeneID | 14420 | |
| KEGG | mmu:14420 | |
| UCSC | uc007olf.1 | |
| CTD | 2581 | |
| MGI | MGI:95636 | |
| eggNOG | NOG76999 | |
| GeneTree | ENSGT00390000003303 | |
| HOGENOM | HOG000068033 | |
| HOVERGEN | HBG005800 | |
| InParanoid | P54818 | |
| KO | K01202 | |
| OMA | PVWVSAH | |
| OrthoDB | EOG77WWCH | |
| PhylomeDB | P54818 | |
| TreeFam | TF312985 | |
| Reactome | REACT_199008 | |
| ChiTaRS | Galc | |
| NextBio | 286009 | |
| PRO | PR:P54818 | |
| Proteomes | UP000000589 | |
| Bgee | P54818 | |
| CleanEx | MM_GALC | |
| Genevestigator | P54818 | |
| GO | GO:0005764 GO:0005739 GO:0004336 GO:0005975 GO:0006683 | |
| Gene3D | 3.20.20.80 | |
| InterPro | IPR001286 IPR013781 IPR017853 | |
| PANTHER | PTHR15172 | |
| Pfam | PF02057 | |
| PRINTS | PR00850 | |
| SUPFAM | SSF51445 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005764 |
lysosome |
ECO:0000314 |
C |
fig 4 |
complete | |||||
|
involved_in |
GO:0006683 |
galactosylceramide catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004336 |
galactosylceramidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042552 |
myelination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856218 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006683 |
galactosylceramide catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856218 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006683 |
galactosylceramide catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004336 |
galactosylceramidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856218 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004336 |
galactosylceramidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856218 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004336 |
galactosylceramidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004336 |
galactosylceramidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006683 |
galactosylceramide catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004336 |
galactosylceramidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006665 |
sphingolipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zhang, XY et al. (2008) Cellular uptake and lysosomal delivery of galactocerebrosidase tagged with the HIV Tat protein transduction domain. J. Neurochem. 104 1055-64 PubMed GONUTS page
- ↑ 2.0 2.1 Sakai, N et al. (1996) Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease. J. Neurochem. 66 1118-24 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Matsuda, J et al. (2001) A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse. Hum. Mol. Genet. 10 1191-9 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ 5.0 5.1 Whitfield, PD et al. (2001) Quantification of galactosylsphingosine in the twitcher mouse using electrospray ionization-tandem mass spectrometry. J. Lipid Res. 42 2092-5 PubMed GONUTS page
