MOUSE:FMN2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fmn2
Protein Name(s)	Formin-2
External Links
UniProt	Q9JL04
EMBL	AF218940 BC094606
CCDS	CCDS48459.1
RefSeq	NP_062318.2
UniGene	Mm.330620
ProteinModelPortal	Q9JL04
DIP	DIP-60685N
PhosphoSite	Q9JL04
MaxQB	Q9JL04
PaxDb	Q9JL04
PRIDE	Q9JL04
Ensembl	ENSMUST00000030039
GeneID	54418
KEGG	mmu:54418
UCSC	uc007dtd.2
CTD	56776
MGI	MGI:1859252
eggNOG	NOG264408
GeneTree	ENSGT00760000119258
HOGENOM	HOG000112618
HOVERGEN	HBG107923
InParanoid	Q9JL04
KO	K02184
OMA	ARCTEHV
OrthoDB	EOG78M01H
PhylomeDB	Q9JL04
TreeFam	TF326072
ChiTaRS	Fmn2
NextBio	311284
PRO	PR:Q9JL04
Proteomes	UP000000589
Bgee	Q9JL04
CleanEx	MM_FMN2
Genevestigator	Q9JL04
GO	GO:0005884 GO:0005938 GO:0030659 GO:0005829 GO:0005783 GO:0005789 GO:0005902 GO:0005730 GO:0005886 GO:0005819 GO:0003779 GO:0051017 GO:0045010 GO:0006974 GO:0071456 GO:0051295 GO:0070649 GO:0051758 GO:0046907 GO:0016344 GO:0007275 GO:0043066 GO:0042177 GO:0048477 GO:0040038 GO:0015031 GO:0016192
InterPro	IPR015425 IPR001265 IPR009408
Pfam	PF06346 PF02181
PRINTS	PR00828
SMART	SM00498
PROSITE	PS51444

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	C	Seeded From UniProt	complete
involved_in	GO:2000781	positive regulation of double-strand break repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
involved_in	GO:0070649	formin-nucleated actin cable assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
involved_in	GO:0051758	homologous chromosome movement towards spindle pole involved in homologous chromosome segregation	PMID:12447394^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051295	establishment of meiotic spindle localization	PMID:12447394^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:12447394^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040038	polar body extrusion after meiotic divisions	PMID:12447394^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
involved_in	GO:0070649	formin-nucleated actin cable assembly	PMID:21620703^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051295	establishment of meiotic spindle localization	PMID:21620703^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046907	intracellular transport	PMID:21983562^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:21983562^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:21983562^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0015629	actin cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21983562^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NZ56	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000781	positive regulation of double-strand break repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070649	formin-nucleated actin cable assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051017	actin filament bundle assembly	PMID:23439682^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016344	meiotic chromosome movement towards spindle pole	PMID:23439682^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	P	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	PMID:23439682^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	PMID:23439682^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:23439682^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:23439682^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NZ56	F	Seeded From UniProt	complete
involved_in	GO:2000781	positive regulation of double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	P	Seeded From UniProt	complete
involved_in	GO:0070649	formin-nucleated actin cable assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	P	Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	P	Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NZ56 ensembl:ENSP00000318884	F	Seeded From UniProt	complete
part_of	GO:0005884	actin filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001265	C	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001265	F	Seeded From UniProt	complete
involved_in	GO:0045010	actin nucleation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001265	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Leader, B et al. (2002) Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat. Cell Biol. 4 921-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Pfender, S et al. (2011) Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Curr. Biol. 21 955-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Schuh, M (2011) An actin-dependent mechanism for long-range vesicle transport. Nat. Cell Biol. 13 1431-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Yi, K et al. (2013) Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes. J. Cell Biol. 200 567-76 PubMed GONUTS page

[PMID:12447394-1] 1.0 ^1.1 ^1.2 ^1.3 Leader, B et al. (2002) Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat. Cell Biol. 4 921-8 PubMed GONUTS page

[PMID:21620703-2] 2.0 ^2.1 Pfender, S et al. (2011) Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Curr. Biol. 21 955-60 PubMed GONUTS page

[PMID:21983562-3] 3.0 ^3.1 ^3.2 ^3.3 Schuh, M (2011) An actin-dependent mechanism for long-range vesicle transport. Nat. Cell Biol. 13 1431-6 PubMed GONUTS page

[PMID:23439682-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Yi, K et al. (2013) Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes. J. Cell Biol. 200 567-76 PubMed GONUTS page

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MOUSE:FMN2

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