MOUSE:EMD

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Emd (synonyms: Sta)
Protein Name(s)	Emerin
External Links
UniProt	O08579
EMBL	U79753 U73902 AK146361 AK167852 CH466650 BC132131 BC132133
CCDS	CCDS30222.1
RefSeq	NP_031953.1
UniGene	Mm.18892
ProteinModelPortal	O08579
SMR	O08579
BioGrid	199436
IntAct	O08579
MINT	MINT-4094379
STRING	10090.ENSMUSP00000002029
PhosphoSite	O08579
MaxQB	O08579
PaxDb	O08579
PRIDE	O08579
Ensembl	ENSMUST00000002029
GeneID	13726
KEGG	mmu:13726
UCSC	uc009toa.1
CTD	2010
MGI	MGI:108117
eggNOG	NOG46326
GeneTree	ENSGT00390000002034
HOGENOM	HOG000081509
HOVERGEN	HBG001099
InParanoid	O08579
KO	K12569
OMA	NIXLDSG
OrthoDB	EOG7DFXDP
PhylomeDB	O08579
TreeFam	TF337236
Reactome	REACT_208718 REACT_210180 REACT_221677
ChiTaRS	Emd
NextBio	284512
PMAP-CutDB	O08579
PRO	PR:O08579
Proteomes	UP000000589
Bgee	O08579
CleanEx	MM_EMD
ExpressionAtlas	O08579
Genevestigator	O08579
GO	GO:0005783 GO:0016021 GO:0005874 GO:0005635 GO:0005637 GO:0005652 GO:0005640 GO:0005634 GO:0071363 GO:0035414 GO:0048147 GO:0046827 GO:0060828 GO:0035914
Gene3D	1.10.720.40
InterPro	IPR011015 IPR003887
Pfam	PF03020
SMART	SM00540
SUPFAM	SSF63451
PROSITE	PS50954

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005635	nuclear envelope	PMID:19933576^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001032280 UniProtKB:P50402	P	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001032280 UniProtKB:P50402	F	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001032280 UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001032280 RGD:2551	C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001032280 UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108117 PANTHER:PTN001032280 RGD:2551 UniProtKB:P50402	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001032280 UniProtKB:P50402	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060828	regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	P	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035914	skeletal muscle cell differentiation	PMID:19720741^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2385045	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035914	skeletal muscle cell differentiation	PMID:19720741^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0032541	cortical endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:17164264^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
colocalizes_with	GO:0031616	spindle pole centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2551	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2551	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2551	C	Seeded From UniProt	complete
colocalizes_with	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22349700^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P50402	F	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	P	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	P	Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	P	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	F	Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	P	Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	P	Seeded From UniProt	complete
part_of	GO:0032541	cortical endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
part_of	GO:0031616	spindle pole centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50402 ensembl:ENSP00000358857	F	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR035004	C	Seeded From UniProt	complete
part_of	GO:0005652	nuclear lamina	PMID:11591818^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:11591818^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F	Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0183	C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0179	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Haque, F et al. (2010) Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J. Biol. Chem. 285 3487-98 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Huber, MD et al. (2009) Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. Mol. Cell. Biol. 29 5718-28 PubMed GONUTS page
↑ Heydemann, A et al. (2007) Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Hum. Mol. Genet. 16 355-63 PubMed GONUTS page
↑ Borrego-Pinto, J et al. (2012) Samp1 is a component of TAN lines and is required for nuclear movement. J. Cell. Sci. 125 1099-105 PubMed GONUTS page
↑ ^6.0 ^6.1 Nili, E et al. (2001) Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J. Cell. Sci. 114 3297-307 PubMed GONUTS page

[PMID:19933576-1] Haque, F et al. (2010) Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J. Biol. Chem. 285 3487-98 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19720741-3] 3.0 ^3.1 Huber, MD et al. (2009) Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. Mol. Cell. Biol. 29 5718-28 PubMed GONUTS page

[PMID:17164264-4] Heydemann, A et al. (2007) Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Hum. Mol. Genet. 16 355-63 PubMed GONUTS page

[PMID:22349700-5] Borrego-Pinto, J et al. (2012) Samp1 is a component of TAN lines and is required for nuclear movement. J. Cell. Sci. 125 1099-105 PubMed GONUTS page

[PMID:11591818-6] 6.0 ^6.1 Nili, E et al. (2001) Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J. Cell. Sci. 114 3297-307 PubMed GONUTS page

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MOUSE:EMD

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