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MOUSE:EEA1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Eea1
Protein Name(s) Early endosome antigen 1
External Links
UniProt Q8BL66
EMBL BC075637
AK046231
CCDS CCDS36042.1
RefSeq NP_001001932.1
UniGene Mm.210035
Mm.490373
ProteinModelPortal Q8BL66
SMR Q8BL66
BioGrid 229728
IntAct Q8BL66
MINT Q8BL66
STRING 10090.ENSMUSP00000061493
iPTMnet Q8BL66
PhosphoSitePlus Q8BL66
REPRODUCTION-2DPAGE IPI00453776
EPD Q8BL66
MaxQB Q8BL66
PaxDb Q8BL66
PeptideAtlas Q8BL66
PRIDE Q8BL66
Ensembl ENSMUST00000053484
GeneID 216238
KEGG mmu:216238
UCSC uc007gwu.1
CTD 8411
MGI MGI:2442192
eggNOG ENOG410IFA7
ENOG4111F3Q
GeneTree ENSGT00910000144126
HOGENOM HOG000112329
HOVERGEN HBG039440
InParanoid Q8BL66
KO K12478
OMA FIAVYQH
OrthoDB EOG091G01M6
PhylomeDB Q8BL66
TreeFam TF329698
Reactome R-MMU-168138
PRO PR:Q8BL66
Proteomes UP000000589
Bgee ENSMUSG00000036499
CleanEx MM_EEA1
ExpressionAtlas Q8BL66
Genevisible Q8BL66
GO GO:0044308
GO:0031410
GO:0005829
GO:0005769
GO:0031901
GO:0005768
GO:0019897
GO:0055037
GO:0005969
GO:0005545
GO:0030742
GO:0046872
GO:0003676
GO:0042803
GO:0006897
GO:0006906
GO:0039694
Gene3D 3.30.40.10
InterPro IPR013087
IPR000306
IPR017455
IPR011011
IPR013083
Pfam PF01363
SMART SM00064
SUPFAM SSF57903
PROSITE PS50178
PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0019897

extrinsic component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15075

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

enables

GO:0005545

1-phosphatidylinositol binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15075

F

Seeded From UniProt

complete

part_of

GO:0055037

recycling endosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310167

C

Seeded From UniProt

complete

part_of

GO:0044308

axonal spine

PMID:23303939[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0039694

viral RNA genome replication

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:23553667[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030742

GTP-dependent protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

F

Seeded From UniProt

complete

part_of

GO:0019897

extrinsic component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006906

vesicle fusion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006897

endocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

P

Seeded From UniProt

complete

part_of

GO:0005969

serine-pyruvate aminotransferase complex

PMID:16399794[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:26965651[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:24760869[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:24334765[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:24029230[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:23926254[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17606)
  • part_of:(CL:0000207)

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:23918928[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:21300787[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:20943658[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:18838382[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:17765678[13]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:17716972[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:17620357[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:17003038[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:16204232[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:15975910[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:15588329[19]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)
  • part_of:(CL:0000120)

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:15078902[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:14668490[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:12746448[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:25327288[23]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:22792322[24]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q05D76

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:15229288[25]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:12536145[26]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8BL66

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:26582200[27]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:24239381[28]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:16923123[29]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:14718562[30]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:12890772[31]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005545

1-phosphatidylinositol binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15075

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

F

Seeded From UniProt

complete

involved_in

GO:0039694

viral RNA genome replication

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

P

Seeded From UniProt

complete

enables

GO:0030742

GTP-dependent protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

F

Seeded From UniProt

complete

part_of

GO:0019897

extrinsic component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

C

Seeded From UniProt

complete

involved_in

GO:0006906

vesicle fusion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

P

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

C

Seeded From UniProt

complete

enables

GO:0005545

1-phosphatidylinositol binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15075
ensembl:ENSP00000317955

F

Seeded From UniProt

complete

part_of

GO:0055037

recycling endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2K051
ensembl:ENSRNOP00000071305

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000306

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0031901

early endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0093

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Deane, EC et al. (2013) Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J. Neurosci. 33 595-610 PubMed GONUTS page
  2. ↑ Gouttenoire, EA et al. (2013) Sh3tc2 deficiency affects neuregulin-1/ErbB signaling. Glia 61 1041-51 PubMed GONUTS page
  3. ↑ Berger, P et al. (2006) Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. Hum. Mol. Genet. 15 569-79 PubMed GONUTS page
  4. ↑ Bartuzi, P et al. (2016) CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun 7 10961 PubMed GONUTS page
  5. ↑ Yu, T et al. (2014) In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J. Neurosci. 34 6098-106 PubMed GONUTS page
  6. ↑ Qin, Y et al. (2014) The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. Hum. Mol. Genet. 23 2428-39 PubMed GONUTS page
  7. ↑ Nagamachi, A et al. (2013) Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell 24 305-17 PubMed GONUTS page
  8. ↑ Kaneko-Goto, T et al. (2013) Goofy coordinates the acuity of olfactory signaling. J. Neurosci. 33 12987-96, 12996a PubMed GONUTS page
  9. ↑ Essalmani, R et al. (2013) Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J. Biol. Chem. 288 26410-8 PubMed GONUTS page
  10. ↑ Cai, L et al. (2011) Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C). Mol. Cell. Biol. 31 1734-47 PubMed GONUTS page
  11. ↑ Mayer, PR et al. (2010) Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J. Biol. Chem. 285 40387-96 PubMed GONUTS page
  12. ↑ Huber, C et al. (2008) FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J. Biol. Chem. 283 34002-12 PubMed GONUTS page
  13. ↑ Nechiporuk, T et al. (2007) Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice. Dev. Cell 13 338-50 PubMed GONUTS page
  14. ↑ Liu, L et al. (2007) Tetraspanin CD151 promotes cell migration by regulating integrin trafficking. J. Biol. Chem. 282 31631-42 PubMed GONUTS page
  15. ↑ Stober, CB et al. (2007) Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function. Infect. Immun. 75 5059-67 PubMed GONUTS page
  16. ↑ Hatanaka, T et al. (2006) Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2. J. Biol. Chem. 281 35922-30 PubMed GONUTS page
  17. ↑ Maric, J et al. (2005) Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J. Biol. Chem. 280 39942-9 PubMed GONUTS page
  18. ↑ Reed, BC et al. (2005) GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol. Biol. Cell 16 4183-201 PubMed GONUTS page
  19. ↑ Fossale, E et al. (2004) Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis. BMC Neurosci 5 57 PubMed GONUTS page
  20. ↑ Seaman, MN (2004) Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J. Cell Biol. 165 111-22 PubMed GONUTS page
  21. ↑ Richardson, SC et al. (2004) Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Mol. Biol. Cell 15 1197-210 PubMed GONUTS page
  22. ↑ Jones, C et al. (2003) Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J. Biol. Chem. 278 29024-30 PubMed GONUTS page
  23. ↑ Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
  24. ↑ Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page
  25. ↑ Coumailleau, F et al. (2004) Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol. Biol. Cell 15 4444-56 PubMed GONUTS page
  26. ↑ Gurung, R et al. (2003) Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J. Biol. Chem. 278 11376-85 PubMed GONUTS page
  27. ↑ Urresti, J et al. (2016) Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J. Biol. Chem. 291 1221-34 PubMed GONUTS page
  28. ↑ Liegel, RP et al. (2013) Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am. J. Hum. Genet. 93 1001-14 PubMed GONUTS page
  29. ↑ Itoh, T et al. (2006) Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Genes Cells 11 1023-37 PubMed GONUTS page
  30. ↑ Du, G et al. (2004) Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol. Biol. Cell 15 1024-30 PubMed GONUTS page
  31. ↑ Cataldo, AM et al. (2003) App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J. Neurosci. 23 6788-92 PubMed GONUTS page
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