MOUSE:DNM1L

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Dnm1l (synonyms: Drp1)
Protein Name(s)	Dynamin-1-like protein Dynamin family member proline-rich carboxyl-terminal domain less Dymple Dynamin-related protein 1
External Links
UniProt	Q8K1M6
EMBL	AB079133 AK051443 AK080871 BC027538 BC040777 BC079635 CF914619
CCDS	CCDS27984.1 CCDS70689.1
RefSeq	NP_001021118.1 NP_001263269.1 NP_001263270.1 NP_690029.2 XP_006522694.1
UniGene	Mm.218820
ProteinModelPortal	Q8K1M6
SMR	Q8K1M6
BioGrid	216417
DIP	DIP-54818N
IntAct	Q8K1M6
MINT	MINT-1858955
ChEMBL	CHEMBL2331072
iPTMnet	Q8K1M6
PhosphoSitePlus	Q8K1M6
PeptideAtlas	Q8K1M6
PRIDE	Q8K1M6
Ensembl	ENSMUST00000023477 ENSMUST00000115749
GeneID	74006
KEGG	mmu:74006
UCSC	uc007yij.2 uc007yik.2 uc007yim.2 uc007yin.2 uc007yio.2
CTD	10059
MGI	MGI:1921256
GeneTree	ENSGT00760000119213
HOGENOM	HOG000161068
HOVERGEN	HBG107833
InParanoid	Q8K1M6
KO	K17065
OMA	GQEPTTG
OrthoDB	EOG091G02TQ
PhylomeDB	Q8K1M6
TreeFam	TF352031
Reactome	[www.reactome.org/content/detail/R-MMU-75153 R-MMU-75153]
PRO	PR:Q8K1M6
Proteomes	UP000000589
Bgee	ENSMUSG00000022789
CleanEx	MM_DNM1L
ExpressionAtlas	Q8K1M6
Genevisible	Q8K1M6
GO	GO:0005903 GO:0030054 GO:0005905 GO:0005737 GO:0005829 GO:0005783 GO:0005794 GO:0000139 GO:0043231 GO:0016020 GO:0005874 GO:0015630 GO:0005741 GO:0005739 GO:0099073 GO:0048471 GO:0005777 GO:0043234 GO:0030672 GO:0005525 GO:0030742 GO:0003924 GO:0042802 GO:0008289 GO:0008017 GO:0042803 GO:0017137 GO:0031625 GO:0003374 GO:0006897 GO:0060047 GO:0048312 GO:0061025 GO:0000266 GO:0043653 GO:0090149 GO:0070584 GO:0007005 GO:0070266 GO:0016559 GO:0043065 GO:2001244 GO:0090141 GO:0050714 GO:0090200 GO:0051289 GO:0070585 GO:0051259 GO:1903578 GO:0010821 GO:1903146 GO:1900063 GO:0032459 GO:0001836
Gene3D	3.40.50.300
InterPro	IPR030556 IPR000375 IPR001401 IPR019762 IPR022812 IPR030381 IPR003130 IPR020850 IPR027417
PANTHER	PTHR11566 PTHR11566:SF127
Pfam	PF01031 PF00350 PF02212
PRINTS	PR00195
SMART	SM00053 SM00302
SUPFAM	SSF52540
PROSITE	PS00410 PS51718 PS51388

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008637	apoptotic mitochondrial changes	PMID:28282614^[1]	ECO:0000314			P		MOUSE DNM1L (DRP1) // Mdivi, a specific inhibitor for Drp1, inhibited Sene-induced mitochondrial fragmentation (Fig. 5A).	complete CACAO 12391
	GO:0051882	mitochondrial depolarization	PMID:28282614^[1]	ECO:0000314			P		MOUSE DNM1L (DRP1) // Mdivi, a specific inhibitor for Drp1, inhibited Sene-induced mitochondrial depolarization (Fig. 5C-G).	complete CACAO 12413
involved_in	GO:0060047	heart contraction	PMID:20585624^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900063	regulation of peroxisome organization	PMID:20585624^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	PMID:20585624^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:1903578	regulation of ATP metabolic process	PMID:20585624^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000746) occurs_in:(GO:0005739)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:20585624^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005903	brush border	PMID:22114352^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000584)	Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	PMID:22265414^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	F		Seeded From UniProt	complete
involved_in	GO:0016559	peroxisome fission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:23283981^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23283981^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	F		Seeded From UniProt	complete
involved_in	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:23283981^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002480309 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0061025	membrane fusion	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0048312	intracellular distribution of mitochondria	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002480309 RGD:620416 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0043653	mitochondrial fragmentation involved in apoptotic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002480309 RGD:620416 UniProtKB:O00429	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 RGD:620416	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170013 TAIR:locus:2006777 TAIR:locus:2012763 UniProtKB:Q8S944	C		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1921256 PANTHER:PTN002480309 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002480309 WB:WBGene00001093	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 PANTHER:PTN000170013	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 MGI:MGI:1921256 PANTHER:PTN000170013 PomBase:SPBC12C2.08 RGD:2513 RGD:628821 RGD:71096 RGD:727949 TAIR:locus:2006777 UniProtKB:K7GKN2 UniProtKB:O00429 UniProtKB:P20591 UniProtKB:P27594 UniProtKB:P79135 UniProtKB:Q8IHR4 dictyBase:DDB_G0277849 dictyBase:DDB_G0277851	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170013 RGD:2513 RGD:727949 SGD:S000001709 SGD:S000003924 UniProtKB:K7GKN2 UniProtKB:O00429 UniProtKB:O60313 UniProtKB:P27594 UniProtKB:P42697 UniProtKB:Q8S944 WB:WBGene00001130 dictyBase:DDB_G0277849	F		Seeded From UniProt	complete
involved_in	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026479 MGI:MGI:1921256 PANTHER:PTN000902162 SGD:S000003924 TAIR:locus:2006777 UniProtKB:O00429 UniProtKB:Q8LFT2 UniProtKB:Q8S944 WB:WBGene00001093	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904666	regulation of ubiquitin protein ligase activity	PMID:28063983^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5312923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904579	cellular response to thapsigargin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903146	regulation of autophagy of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900063	regulation of peroxisome organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
part_of	GO:0099503	secretory vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
colocalizes_with	GO:0099073	mitochondrion-derived vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0098835	presynaptic endocytic zone membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090149	mitochondrial membrane fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090141	positive regulation of mitochondrial fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090141	positive regulation of mitochondrial fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070585	protein localization to mitochondrion	PMID:24515348^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070584	mitochondrion morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070584	mitochondrion morphogenesis	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070266	necroptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061025	membrane fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061003	positive regulation of dendritic spine morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
enables	GO:0051433	BH2 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051289	protein homotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050714	positive regulation of protein secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048488	synaptic vesicle endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048312	intracellular distribution of mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048312	intracellular distribution of mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043653	mitochondrial fragmentation involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043653	mitochondrial fragmentation involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036466	synaptic vesicle recycling via endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032459	regulation of protein oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
colocalizes_with	GO:0031966	mitochondrial membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	F		Seeded From UniProt	complete
enables	GO:0030742	GTP-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	F		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	F		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016559	peroxisome fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010821	regulation of mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010637	negative regulation of mitochondrial fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:28063983^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5312923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	PMID:28063983^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5312923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:28063983^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5312923	P		Seeded From UniProt	complete
colocalizes_with	GO:0005905	clathrin-coated pit	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21149567^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:28063983^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:26219591^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:24515348^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000266	mitochondrial fission	PMID:22493254^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000266	mitochondrial fission	PMID:20038678^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000266	mitochondrial fission	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00429	P		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620416	C		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:1900063	regulation of peroxisome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
part_of	GO:0099073	mitochondrion-derived vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0090149	mitochondrial membrane fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0070584	mitochondrion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0061025	membrane fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
involved_in	GO:0048312	intracellular distribution of mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0043653	mitochondrial fragmentation involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
involved_in	GO:0032459	regulation of protein oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	F		Seeded From UniProt	complete
enables	GO:0030742	GTP-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	F		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	F		Seeded From UniProt	complete
involved_in	GO:0016559	peroxisome fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	F		Seeded From UniProt	complete
involved_in	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00429 ensembl:ENSP00000449089	P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:1990910	response to hypobaric hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:1905395	response to flavonoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:1904579	cellular response to thapsigargin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0099503	secretory vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0098835	presynaptic endocytic zone membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
involved_in	GO:0090650	cellular response to oxygen-glucose deprivation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0071396	cellular response to lipid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0070584	mitochondrion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0061003	positive regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
enables	GO:0051433	BH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
involved_in	GO:0048312	intracellular distribution of mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	F		Seeded From UniProt	complete
involved_in	GO:0043653	mitochondrial fragmentation involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
involved_in	GO:0036466	synaptic vesicle recycling via endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	F		Seeded From UniProt	complete
involved_in	GO:0010637	negative regulation of mitochondrial fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35303 ensembl:ENSRNOP00000002478	C		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030556	P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001401 InterPro:IPR003130 InterPro:IPR030556	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000375 InterPro:IPR001401 InterPro:IPR003130 InterPro:IPR030381	F		Seeded From UniProt	complete
involved_in	GO:0016559	peroxisome fission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030556	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23798729^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:23798729^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0051325)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23798729^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1210	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576 UniProtKB-SubCell:SL-0204	C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0260	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yang, X et al. (2017) Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biol 12 264-273 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Ashrafian, H et al. (2010) A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet. 6 e1001000 PubMed GONUTS page
↑ Revenu, C et al. (2012) A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol. Biol. Cell 23 324-36 PubMed GONUTS page
↑ Wang, Z et al. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148 228-43 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Losón, OC et al. (2013) Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol. Biol. Cell 24 659-67 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Upadhyay, M et al. (2017) Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiol. Dis. 100 39-51 PubMed GONUTS page
↑ ^8.0 ^8.1 Richter, V et al. (2014) Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. J. Cell Biol. 204 477-86 PubMed GONUTS page
↑ Otera, H et al. (2010) Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J. Cell Biol. 191 1141-58 PubMed GONUTS page
↑ Maryanovich, M et al. (2015) An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nat Commun 6 7901 PubMed GONUTS page
↑ Whelan, RS et al. (2012) Bax regulates primary necrosis through mitochondrial dynamics. Proc. Natl. Acad. Sci. U.S.A. 109 6566-71 PubMed GONUTS page
↑ Ehses, S et al. (2009) Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J. Cell Biol. 187 1023-36 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Strack, S et al. (2013) Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules. J. Cell Biol. 201 1037-51 PubMed GONUTS page

[PMID:28282614-1] 1.0 ^1.1 Yang, X et al. (2017) Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biol 12 264-273 PubMed GONUTS page

[PMID:20585624-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Ashrafian, H et al. (2010) A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet. 6 e1001000 PubMed GONUTS page

[PMID:22114352-3] Revenu, C et al. (2012) A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol. Biol. Cell 23 324-36 PubMed GONUTS page

[PMID:22265414-4] Wang, Z et al. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148 228-43 PubMed GONUTS page

[PMID:23283981-5] 5.0 ^5.1 ^5.2 Losón, OC et al. (2013) Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol. Biol. Cell 24 659-67 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28063983-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Upadhyay, M et al. (2017) Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiol. Dis. 100 39-51 PubMed GONUTS page

[PMID:24515348-8] 8.0 ^8.1 Richter, V et al. (2014) Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. J. Cell Biol. 204 477-86 PubMed GONUTS page

[PMID:21149567-9] Otera, H et al. (2010) Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J. Cell Biol. 191 1141-58 PubMed GONUTS page

[PMID:26219591-10] Maryanovich, M et al. (2015) An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nat Commun 6 7901 PubMed GONUTS page

[PMID:22493254-11] Whelan, RS et al. (2012) Bax regulates primary necrosis through mitochondrial dynamics. Proc. Natl. Acad. Sci. U.S.A. 109 6566-71 PubMed GONUTS page

[PMID:20038678-12] Ehses, S et al. (2009) Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J. Cell Biol. 187 1023-36 PubMed GONUTS page

[PMID:23798729-13] 13.0 ^13.1 ^13.2 Strack, S et al. (2013) Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules. J. Cell Biol. 201 1037-51 PubMed GONUTS page

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