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MOUSE:DFA20

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Defa20 (synonyms: Defcr20)
Protein Name(s) Alpha-defensin 20

Cryptdin-4 Defensin-related cryptdin-20

External Links
UniProt Q45VN2
EMBL DQ103703
AK008107
AK008275
AC239604
CCDS CCDS40273.1
RefSeq NP_001170992.1
NP_899091.2
UniGene Mm.327348
Mm.423382
ProteinModelPortal Q45VN2
SMR Q45VN2
STRING 10090.ENSMUSP00000081055
PaxDb Q45VN2
PRIDE Q45VN2
Ensembl ENSMUST00000084041
ENSMUST00000084042
GeneID 100041890
68009
KEGG mmu:100041890
mmu:68009
UCSC uc009lbq.2
CTD 68009
MGI MGI:1915259
eggNOG ENOG410JFE2
ENOG4111A2R
GeneTree ENSGT00840000130112
HOGENOM HOG000233351
HOVERGEN HBG011703
InParanoid Q45VN2
KO K05230
OMA EGIMGIC
PhylomeDB Q45VN2
TreeFam TF338414
PRO PR:Q45VN2
Proteomes UP000000589
CleanEx MM_DEFCR20
GO GO:0005615
GO:0019731
InterPro IPR016327
IPR006080
IPR002366
PANTHER PTHR11876
Pfam PF00879
PIRSF PIRSF001875
SMART SM00048

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051873

killing by host of symbiont cells

PMID:15297466[1]

ECO:0000314

P

Figure 3.

complete
CACAO 12109

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
PANTHER:PTN002275316

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59665
UniProtKB:P59666

P

Seeded From UniProt

complete

involved_in

GO:0051673

membrane disruption in other organism

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99584
MGI:MGI:99592
PANTHER:PTN002275316

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59666
UniProtKB:P82270
UniProtKB:P82271
UniProtKB:Q01523

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
MGI:MGI:99582
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P82270
UniProtKB:P82271
UniProtKB:Q01523

P

Seeded From UniProt

complete

involved_in

GO:0019731

antibacterial humoral response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915259
MGI:MGI:3630383
MGI:MGI:99584
PANTHER:PTN002275316
UniProtKB:P12838
UniProtKB:P59666

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915259
MGI:MGI:3630383
MGI:MGI:94880
MGI:MGI:94882
MGI:MGI:94883
MGI:MGI:99584
PANTHER:PTN002275315
UniProtKB:P59666

C

Seeded From UniProt

complete

involved_in

GO:0002227

innate immune response in mucosa

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002275316
UniProtKB:P59665
UniProtKB:P59666

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019731

antibacterial humoral response

PMID:21041494[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21041494[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006080

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016327

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002366
InterPro:IPR006080
InterPro:IPR016327

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0211

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0044

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Maemoto, A et al. (2004) Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J. Biol. Chem. 279 44188-96 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 Shanahan, MT et al. (2011) Strain-specific polymorphisms in Paneth cell α-defensins of C57BL/6 mice and evidence of vestigial myeloid α-defensin pseudogenes. Infect. Immun. 79 459-73 PubMed GONUTS page