MOUSE:DEFA1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Defa1 (synonyms: Defcr, Defcr1)
Protein Name(s)	Alpha-defensin 1 Cryptdin-1 Defensin-related cryptdin peptide
External Links
UniProt	P11477
EMBL	M33225 U02995 U02994 X15617
PIR	A36438
RefSeq	NP_034161.2
UniGene	Mm.425522
ProteinModelPortal	P11477
SMR	P11477
STRING	10090.ENSMUSP00000096492
PRIDE	P11477
GeneID	13216
KEGG	mmu:13216
CTD	1667
MGI	MGI:94880
eggNOG	NOG145841
HOGENOM	HOG000233351
HOVERGEN	HBG011703
InParanoid	P11477
KO	K05230
PhylomeDB	P11477
NextBio	283394
PRO	PR:P11477
Proteomes	UP000000589
CleanEx	MM_DEFA1
Genevestigator	P11477
GO	GO:0005615 GO:0071222 GO:0042742 GO:0050829 GO:0050830 GO:0042493
InterPro	IPR016327 IPR006080 IPR002366 IPR006081
PANTHER	PTHR11876
Pfam	PF00323 PF00879
PIRSF	PIRSF001875
SMART	SM00048
PROSITE	PS00269

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042581	specific granule	PMID:1500163^[1]	ECO:0000314			C	figure 6- immunohistochemical localization to the Paneth cell granules	complete
	GO:0050830	defense response to Gram-positive bacterium	PMID:1500163^[1]	ECO:0000314			P	figure 8	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 PANTHER:PTN002275316	P	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59665 UniProtKB:P59666	P	Seeded From UniProt	complete
involved_in	GO:0051673	membrane disruption in other organism	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99584 MGI:MGI:99592 PANTHER:PTN002275316	P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59666 UniProtKB:P82270 UniProtKB:P82271 UniProtKB:Q01523	P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99582 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P82270 UniProtKB:P82271 UniProtKB:Q01523	P	Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915259 MGI:MGI:3630383 MGI:MGI:99584 PANTHER:PTN002275316 UniProtKB:P12838 UniProtKB:P59666	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915259 MGI:MGI:3630383 MGI:MGI:94880 MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99584 PANTHER:PTN002275315 UniProtKB:P59666	C	Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002275316 UniProtKB:P59665 UniProtKB:P59666	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:11248802^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99582	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:11248802^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99582	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050829	defense response to Gram-negative bacterium	PMID:17273556^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94882 MGI:MGI:94883 MGI:MGI:99582	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	PMID:7927786^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	PMID:11248802^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11248802^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016327	C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002366 InterPro:IPR006080 InterPro:IPR006081 InterPro:IPR016327	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006080 InterPro:IPR006081	C	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0211	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Eisenhauer, PB et al. (1992) Cryptdins: antimicrobial defensins of the murine small intestine. Infect. Immun. 60 3556-65 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Ayabe, T et al. (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1 113-8 PubMed GONUTS page
↑ Le Bacquer, O et al. (2007) Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J. Clin. Invest. 117 387-96 PubMed GONUTS page
↑ Ouellette, AJ et al. (1994) Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect. Immun. 62 5040-7 PubMed GONUTS page

[PMID:1500163-1] 1.0 ^1.1 Eisenhauer, PB et al. (1992) Cryptdins: antimicrobial defensins of the murine small intestine. Infect. Immun. 60 3556-65 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11248802-3] 3.0 ^3.1 ^3.2 ^3.3 Ayabe, T et al. (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1 113-8 PubMed GONUTS page

[PMID:17273556-4] Le Bacquer, O et al. (2007) Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J. Clin. Invest. 117 387-96 PubMed GONUTS page

[PMID:7927786-5] Ouellette, AJ et al. (1994) Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect. Immun. 62 5040-7 PubMed GONUTS page

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MOUSE:DEFA1

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