MOUSE:D3YTL8

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein spire homolog 1 (ECO:0000313 with Ensembl:ENSMUSP00000049336)
External Links
UniProt	D3YTL8
EMBL	AC120410
RefSeq	NP_919336.1
UniGene	Mm.208723
ProteinModelPortal	D3YTL8
SMR	D3YTL8
STRING	10090.ENSMUSP00000049336
MaxQB	D3YTL8
PaxDb	D3YTL8
PeptideAtlas	D3YTL8
PRIDE	D3YTL8
Ensembl	ENSMUST00000045105
GeneID	68166
UCSC	uc008fmm.1
CTD	56907
MGI	MGI:1915416
eggNOG	ENOG410IK9H ENOG4111E0J
GeneTree	ENSGT00390000003058
HOGENOM	HOG000013039
OMA	STGHHRP
OrthoDB	EOG77DJ5G
TreeFam	TF326239
ChiTaRS	Spire1
Proteomes	UP000000589
Bgee	D3YTL8
ExpressionAtlas	D3YTL8
Genevisible	D3YTL8
GO	GO:0005623 GO:0045010 GO:0051295 GO:0016192
InterPro	IPR011019 IPR029901 IPR029905 IPR011011
PANTHER	PTHR21345 PTHR21345:SF2
Pfam	PF16474
SUPFAM	SSF57903
PROSITE	PS51377

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090141	positive regulation of mitochondrial fission	PMID:26305500	ECO:0000315			P		Figure 4	complete CACAO 12224
	GO:0031307	integral component of mitochondrial outer membrane	PMID:26305500	ECO:0000314			C		Figure 2A - Spire1C is localized at the periphery of the mitochondria. Figure 2D - fluorescence assay demonstrated that the N-terminus of Spire1C is exposed to the cytoplasm while the C-terminus is not	complete CACAO 12225
involved_in	GO:2000781	positive regulation of double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08AE8 ensembl:ENSP00000387266	P		Seeded From UniProt	complete
involved_in	GO:0070649	formin-nucleated actin cable assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08AE8 ensembl:ENSP00000387266	P		Seeded From UniProt	complete
involved_in	GO:0051295	establishment of meiotic spindle localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08AE8 ensembl:ENSP00000387266	P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08AE8 ensembl:ENSP00000387266	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08AE8 ensembl:ENSP00000387266	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08AE8 ensembl:ENSP00000387266	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029901 InterPro:IPR029905	F		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029901 InterPro:IPR029905	P		Seeded From UniProt	complete
involved_in	GO:0045010	actin nucleation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029901 InterPro:IPR029905	P		Seeded From UniProt	complete
	GO:0031307	integral component of mitochondrial outer membrane	PMID:26305500	ECO:0000314			C		Figure 2A - Spire1C is localized at the periphery of the mitochondria. Figure 2D - fluorescence assay demonstrated that the N-terminus of Spire1C is exposed to the cytoplasm while the C-terminus is not	complete CACAO 12203
	GO:0007015	actin filament organization	PMID:26305500	ECO:0000315			P		Figure 3 - cells with overexpression of Spire1C show increased actin assembly on mitochondria as compared to control, while cells with overexpression of mutant Spire1C do not show increased actin assembly on mitochondria as compared to control	complete CACAO 12204
	GO:0030041	actin filament polymerization	PMID:26305500	ECO:0000315			P		Figure 3 - cells with overexpression of Spire1C show increased actin assembly on mitochondria as compared to control, while cells with overexpression of mutant Spire1C do not show increased actin assembly on mitochondria as compared to control	complete CACAO 12205
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References

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