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MOUSE:CXCL9

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cxcl9 (synonyms: Mig, Scyb9)
Protein Name(s) C-X-C motif chemokine 9

Gamma-interferon-induced monokine Monokine induced by interferon-gamma MIG MuMIG Protein m119 Small-inducible cytokine B9

External Links
UniProt P18340
EMBL M34815
AK042017
AK156012
AK156029
AK156453
AK157118
CT010194
AC122365
CH466617
BC003343
CCDS CCDS39152.1
PIR A35766
RefSeq NP_032625.2
UniGene Mm.766
ProteinModelPortal P18340
SMR P18340
PhosphoSite P18340
PRIDE P18340
Ensembl ENSMUST00000113093
GeneID 17329
KEGG mmu:17329
UCSC uc008ycv.2
CTD 4283
MGI MGI:1352449
eggNOG NOG38935
GeneTree ENSGT00530000063958
HOGENOM HOG000220915
HOVERGEN HBG107789
InParanoid P18340
KO K05416
OMA NGDQTCL
OrthoDB EOG7HHWVH
TreeFam TF333433
Reactome REACT_230248
REACT_250376
ChiTaRS Cxcl9
NextBio 291898
PRO PR:P18340
Proteomes UP000000589
CleanEx MM_CXCL9
ExpressionAtlas P18340
Genevestigator P18340
GO GO:0009897
GO:0005615
GO:0008009
GO:0048248
GO:0060326
GO:0006935
GO:0051607
GO:0006955
GO:0006954
GO:0030816
GO:0043950
GO:0045663
GO:1901741
GO:0051281
GO:0042127
InterPro IPR001089
IPR018048
IPR001811
IPR027225
PANTHER PTHR10179
PTHR10179:SF28
Pfam PF00048
PRINTS PR00437
SMART SM00199
SUPFAM SSF54117
PROSITE PS00471

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006935

chemotaxis

PMID:24083082[1]

ECO:0000314

P

Figure 5 illustrates the effect of CXCL9 knockout influences the distribution of Tcell subsets in mice.

complete
CACAO 8780

involved_in

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07325

P

Seeded From UniProt

complete

enables

GO:0048248

CXCR3 chemokine receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07325

F

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07325

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07325

P

Seeded From UniProt

complete

enables

GO:0008009

chemokine activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07325

F

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07325

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000021269
RGD:621812
RGD:70069
RGD:708540
UniProtKB:P02778
UniProtKB:P10145
UniProtKB:P80162
UniProtKB:P80221

P

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000021269
UniProtKB:O14625
UniProtKB:P02778

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1888711
PANTHER:PTN000021269
UniProtKB:P02776
UniProtKB:P80162
UniProtKB:P80221

P

Seeded From UniProt

complete

involved_in

GO:0030595

leukocyte chemotaxis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000021269
RGD:70069
UniProtKB:P02776

P

Seeded From UniProt

complete

involved_in

GO:0030593

neutrophil chemotaxis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1339941
MGI:MGI:3037818
PANTHER:PTN000021269
RGD:619869
RGD:621812
RGD:70069
UniProtKB:P10145
UniProtKB:P79255
UniProtKB:P80162
UniProtKB:P80221

P

Seeded From UniProt

complete

enables

GO:0008009

chemokine activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1339941
MGI:MGI:1888499
MGI:MGI:1888712
MGI:MGI:3037818
PANTHER:PTN000021269
RGD:619869
RGD:620209
RGD:621812
RGD:70069
RGD:708540
RGD:727827
UniProtKB:O14625
UniProtKB:O43927
UniProtKB:P02778
UniProtKB:P10145
UniProtKB:P80162
UniProtKB:P80221
UniProtKB:Q07325

F

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000021269
RGD:3305
RGD:620209
RGD:727827

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1339941
PANTHER:PTN000021269
RGD:621812
RGD:708540

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108068
MGI:MGI:1340094
MGI:MGI:1352449
MGI:MGI:1352450
MGI:MGI:1888499
PANTHER:PTN000021269
RGD:619869
RGD:620209
RGD:621812
RGD:70069
RGD:708540
UniProtKB:P19876

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901741

positive regulation of myoblast fusion

PMID:23844157[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051607

defense response to virus

PMID:17277142[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045663

positive regulation of myoblast differentiation

PMID:23844157[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:19008373[5]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18767)
  • part_of:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009617

response to bacterium

PMID:23012479[6]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:17277142[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07325
ensembl:ENSP00000354901

P

Seeded From UniProt

complete

enables

GO:0048248

CXCR3 chemokine receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07325
ensembl:ENSP00000354901

F

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07325
ensembl:ENSP00000354901

P

Seeded From UniProt

complete

enables

GO:0008009

chemokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07325
ensembl:ENSP00000354901

F

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07325
ensembl:ENSP00000354901

P

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07325
ensembl:ENSP00000354901

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001089
InterPro:IPR001811
InterPro:IPR018048
InterPro:IPR036048

C

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027225
InterPro:IPR033899

P

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033899

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027225

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001089
InterPro:IPR001811
InterPro:IPR018048
InterPro:IPR027225
InterPro:IPR036048

P

Seeded From UniProt

complete

enables

GO:0008009

chemokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001089
InterPro:IPR001811
InterPro:IPR018048
InterPro:IPR027225
InterPro:IPR033899
InterPro:IPR036048

F

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Guirnalda, P et al. (2013) Interferon γ-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Listeria monocytogenes. Oncoimmunology 2 e25752 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Ge, Y et al. (2013) RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation. PLoS ONE 8 e68068 PubMed GONUTS page
  4. ↑ 4.0 4.1 Hervas-Stubbs, S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J. Immunol. 178 2361-9 PubMed GONUTS page
  5. ↑ Abe, J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am. J. Pathol. 173 1682-92 PubMed GONUTS page
  6. ↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page
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